Stem-loop sequence hsa-mir-450a-2

Accession

MI0003187 (change log)

Previous IDs

hsa-mir-450-2

Symbol

HGNC:MIR450A2

Description

Homo sapiens miR-450a-2 stem-loop

Gene family

MIPF0000128; mir-450

Literature search

21 open access papers mention hsa-mir-450a-2
(43 sentences)

Stem-loop

   -ccaaagaaa     u       uuu     u               aa 
5'           gaugc aaacuau   ugcga guguuccuaauaugu  u
             ||||| |||||||   ||||| |||||||||||||||  a
3'           cuaug uuugaua   acguu uacagggguuaugua  u
   gguauaauaa     u       cuu     u               aa 

Deep sequencing

51161 reads, 276 reads per million, 157 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chrX: 134540508-134540607 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from hsa-mir-450a-2

• hsa-mir-424: chrX: 134546614-134546711 [-]
• hsa-mir-503: chrX: 134546328-134546398 [-]
• hsa-mir-542: chrX: 134541341-134541437 [-]
• hsa-mir-450a-2: chrX: 134540508-134540607 [-]
• hsa-mir-450a-1: chrX: 134540341-134540431 [-]
• hsa-mir-450b: chrX: 134540185-134540262 [-]

Database links

• EntrezGene:MIR450A2
• HGNC:MIR450A2
• RNAcentral:URS000075F0A5_9606
• miRBase Tracker:MI0003187

Mature sequence hsa-miR-450a-5p

• Accession: MIMAT0001545
• Previous IDs: hsa-miR-450;hsa-miR-450a
• Sequence: 23 - uuuugcgauguguuccuaauau - 44
• Deep sequencing: 98394 reads, 157 experiments
• Evidence: experimental; array-cloned [1,3], cloned [1,4]
• Database links:
  • RNAcentral:URS00003E5ECC_9606
• Predicted targets:
  • TargetMiner:hsa-miR-450a-5p
  • TargetScanVert:hsa-miR-450a-5p
  • miRDB:hsa-miR-450a-5p
  • microrna.org:hsa-miR-450a-5p

Mature sequence hsa-miR-450a-2-3p

• Accession: MIMAT0031074
• Sequence: 58 - auuggggacauuuugcauucau - 79
• Deep sequencing: 2622 reads, 112 experiments
• Evidence: not experimental
• Database links:
  • RNAcentral:URS000075CA21_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-450a-2-3p
  • miRDB:hsa-miR-450a-2-3p

References

1. PMID:15735639 "Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals" Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M Nature. 434:338-345(2005).
2. PMID:15965474 "Identification of hundreds of conserved and nonconserved human microRNAs" Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z Nat Genet. 37:766-770(2005).
3. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
4. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).