Stem-loop sequence hsa-mir-503

Accession

MI0003188 (change log)

Symbol

HGNC:MIR503

Description

Homo sapiens miR-503 stem-loop

Gene family

MIPF0000183; mir-503

Literature search

113 open access papers mention hsa-mir-503
(873 sentences)

Stem-loop

         a              u  g  gu     a 
5' ugcccu gcagcgggaacagu cu ca  gagcg u
   |||||| |||||||||||||| || ||  ||||| c
3' auggga cgucgccuuuguua gg gu  cucgu g
         c              u  g  --     g 

Deep sequencing

60761 reads, 133 reads per million, 156 experiments

Confidence

Annotation confidence: high

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Genome context

• Coordinates (GRCh38; GCA_000001405.15): chrX: 134546328-134546398 [-]
• Overlapping transcripts:

  intergenic

Clustered miRNAs

< 10kb from hsa-mir-503

• hsa-mir-424: chrX: 134546614-134546711 [-]
• hsa-mir-503: chrX: 134546328-134546398 [-]
• hsa-mir-542: chrX: 134541341-134541437 [-]
• hsa-mir-450a-2: chrX: 134540508-134540607 [-]
• hsa-mir-450a-1: chrX: 134540341-134540431 [-]
• hsa-mir-450b: chrX: 134540185-134540262 [-]

Database links

• EntrezGene:MIR503
• HGNC:MIR503
• RNAcentral:URS00006588D4_9606
• miRBase Tracker:MI0003188

Mature sequence hsa-miR-503-5p

• Accession: MIMAT0002874
• Previous IDs: hsa-miR-503
• Sequence: 6 - uagcagcgggaacaguucugcag - 28
• Deep sequencing: 59540 reads, 156 experiments
• Evidence: experimental; array-cloned [1], cloned [2-3], SOLiD [4]
• Database links:
  • RNAcentral:URS00000F6E49_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-503-5p
  • miRDB:hsa-miR-503-5p
  • microrna.org:hsa-miR-503-5p

Mature sequence hsa-miR-503-3p

• Accession: MIMAT0022925
• Sequence: 46 - gggguauuguuuccgcugccagg - 68
• Deep sequencing: 1196 reads, 48 experiments
• Evidence: experimental; SOLiD [4]
• Database links:
  • RNAcentral:URS00003C11EC_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-503-3p
  • miRDB:hsa-miR-503-3p

References

1. PMID:15965474 "Identification of hundreds of conserved and nonconserved human microRNAs" Bentwich I, Avniel A, Karov Y, Aharonov R, Gilad S, Barad O, Barzilai A, Einat P, Einav U, Meiri E, Sharon E, Spector Y, Bentwich Z Nat Genet. 37:766-770(2005).
2. PMID:16274478 "Identification of clustered microRNAs using an ab initio prediction method" Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M BMC Bioinformatics. 6:267(2005).
3. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
4. PMID:22282338 "Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs" Voellenkle C, Rooij Jv, Guffanti A, Brini E, Fasanaro P, Isaia E, Croft L, David M, Capogrossi MC, Moles A, Felsani A, Martelli F RNA. 18:472-484(2012).