Stem-loop sequence dre-let-7j

AccessionMI0003343 (change log)
DescriptionDanio rerio let-7j stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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Stem-loop
      u        u            --------uu      cu u 
5' ggu gagguagu guuuguacaguu          uagggu  g u
   ||| |||||||| ||||||||||||          ||||||  | a
3' ccg uuccguca cagacaugucaa          gucccg  c u
      -        u            ucgaggaauu      -u u 
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Confidence
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Comments

This zebrafish miRNA sequence is predicted based on homology with a verified mammalian sequence (Mihaela Zavolan, personal communication).

Genome context
Coordinates (GRCz11; GCA_000002035.4) Overlapping transcripts
chr6: 41454791-41454873 [+]
sense
OTTDART00000024645 ; wdr82-001; intron 2
ENSDART00000007353 ; wdr82-001; intron 2
ENSDART00000007798 ; twf2a-201; intron 2
Database links

Mature sequence dre-let-7j

Accession MIMAT0003015
Sequence

4 - 

ugagguaguuguuuguacaguu

 - 25

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Evidence by similarity; MI0001874
Database links
Predicted targets