Accession
MI0003580
Symbol
HGNC:
MIR573
Description
Homo sapiens
hsa-mir-573 precursor miRNA
Gene family
MIPF0000561;
mir-573
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR573 is a microRNA that has been studied in various contexts. In breast cancer (BRCA), it was found that the gene GSDMC was significantly negatively associated with MIR573 and positively linked to MIR548AO [PMC9428000]. In a study of neuroblastoma (NB), genes correlated positively with MIR573 expression were found to be enriched for miR-573 targets [PMC8017594]. MIR573, along with MIR873, was identified as a candidate "MRE-code" miRNA in NB, suggesting its essential role in nucleocytoplasmic transport regulation [PMC8017594]. The expression of the MIR573 precursor was found to be higher in certain stages and types of tumors [PMC8017594]. In acute myeloid leukemia (AML), the gene MIR573 was identified as one of the prognostic genes associated with epithelial-mesenchymal transition (EMT) [PMC9568336]. The role of MIR573 in EMT is still controversial, as it has been shown to both inhibit and associate with EMT in different cancer types [PMC9568336]. Additionally, it has been demonstrated that TF ETS1 can activate MIR573 and negatively regulate the gene ERRFI1 [PMC8197996]. Furthermore, high-throughput sequencing revealed differential expression of several microRNAs, including upregulation of MIR573, when mesenchymal stem cells were co-cultured with human pulmonary arterial endothelial cells [PMC7675022].
Literature search
3 open access papers mention hsa-mir-573
(3 sentences)
(3 sentences)
Sequence
396
reads,
37
reads per million, 31 experiments
uuuagcgguuucuccCUGAAGUGAUGUGUAACUGAUCAGgaucuacucaugucgucuuugguaaaguuaugucgcuugucagggugaggagaguuuuug
...(((..((((.((((((((((((..((((((.((((((((..((....)).))).)))))..))))))))))))..)))))).))))...)))....
...(((..((((.((((((((((((..((((((.((((((((..((....)).))).)))))..))))))))))))..)))))).))))...)))....
Structure
-uuu -gg u -- GU -G - cu u
agc uuuc ccCUGA AGUGAU GUAACU AUCAG gau ac c
||| |||| |||||| |||||| |||||| ||||| ||| ||
uug ggag gggacu ucgcug uauuga ugguu cug ug a
guuu aga u gu -- aa u -c u
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr4: 24520192-24520290 [-]
Disease association
hsa-mir-573 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-573
| Accession | MIMAT0003238 |
| Description | Homo sapiens hsa-miR-573 mature miRNA |
| Sequence | 16 - CUGAAGUGAUGUGUAACUGAUCAG - 39 |
| Evidence |
experimental
SAGE [1] |
| Database links |
|
| Predicted targets |
|
References
|
