miRBase entry: hsa-mir-605

Stem-loop hsa-mir-605


Accession
MI0003618
Symbol
HGNC: MIR605
Description
Homo sapiens hsa-mir-605 precursor miRNA
Gene family
MIPF0000528; mir-605

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR605 is a microRNA that has been found to regulate the p53-MDM2 interaction and is a transcriptional target of p53, participating in a positive feedback loop by degrading MDM2 [PMC3248149]. However, the allelic and genotypic frequencies of the SNVs selected in TP53, MDM2, MIR605, and LIF were not statistically different between CZS and control groups [PMC8294037]. In a study evaluating the effect of ZIKV infection on gene expression in human neuroprogenitor cells (hNPCs), it was found that ZIKV infection did not alter the expression of MIR605 [PMC8294037]. One polymorphism in the MIR605 gene (rs2043556) was significantly associated with infectious-type toxicity during ALL treatment [PMC10003057]. This variant has also been linked to the development of various cancers and may affect the functionality of the MIR605 processing gene [PMC10003057]. Additionally, it was found that variants in genes such as MIR149, MIR938, MIR200C, and MIR2053 were associated with neurological toxicity during ALL treatment [PMC10003057]. These findings suggest that variants in genes like MIR149 and MIR605 can influence toxicity during cancer treatment by playing regulatory roles in cellular environments [PMC10003057]. Overall, these studies highlight the importance of microRNAs like MIR605 in regulating gene expression and their potential role as biomarkers for treatment response or toxicity prediction.

Literature search
10 open access papers mention hsa-mir-605
(37 sentences)

Sequence

472 reads, 139 reads per million, 51 experiments
gcccuagcuugguucUAAAUCCCAUGGUGCCUUCUCCUugggaaaaacagAGAAGGCACUAUGAGAUUUAGAaucaaguuagg
..(((((((((((((((((((.((((((((((((((..((.......)))))))))))))))).)))))))))))))))))))

Structure
gc                   C              CU  gg 
  ccuagcuugguucUAAAUC CAUGGUGCCUUCUC  ug  a
  ||||||||||||||||||| ||||||||||||||  ||  a
  ggauugaacuaAGAUUUAG GUAUCACGGAAGAg  ac  a
--                   A              --  aa 


Annotation confidence High
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Genome context
chr10: 51299573-51299655 [+]

Disease association
hsa-mir-605 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-605-5p

Accession MIMAT0003273
Description Homo sapiens hsa-miR-605-5p mature miRNA
Sequence 16 - UAAAUCCCAUGGUGCCUUCUCCU - 38
Evidence experimental
SAGE [1]

Mature hsa-miR-605-3p

Accession MIMAT0026621
Description Homo sapiens hsa-miR-605-3p mature miRNA
Sequence 51 - AGAAGGCACUAUGAGAUUUAGA - 72
Evidence experimental
Illumina [2]
Database links
Predicted targets

References

  1. PubMed ID: 16505370
    The colorectal microRNAome
    "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
    "Proc Natl Acad Sci U S A (2006) 103:3687-3692

  2. PubMed ID: 23226537
    The repertoire and features of human platelet microRNAs
    Plé H, Landry P, Benham A, Coarfa C, Gunaratne PH, Provost P
    PLoS One (2012) 7:e50746