Stem-loop sequence hsa-mir-449b

Accession

MI0003673 (change log)

Symbol

HGNC:MIR449B

Description

Homo sapiens miR-449b stem-loop

Gene family

MIPF0000133; mir-449

Literature search

83 open access papers mention hsa-mir-449b
(402 sentences)

Stem-loop

   ---------uga  u   u     a     u   uu   a c        u  gu 
5'             cc gaa caggu ggcag gua  guu g uggcugcu gg  c
               || ||| ||||| ||||| |||  ||| | |||||||| ||   
3'             gg cuu guuca ccguc cau  caa c accgacga cu  a
   ucuucuuaaaua  u   c     -     c   --   - -        -  ga 

Deep sequencing

11317 reads, 120 reads per million, 103 experiments

Confidence

Annotation confidence: high

Feedback: Do you believe this miRNA is real?

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr5: 55170646-55170742 [-]
• Overlapping transcripts:

  antisense

  OTTHUMT00000313798 ; IL31RA-004; intron 4

  OTTHUMT00000214148 ; IL31RA-001; intron 4

  OTTHUMT00000313797 ; IL31RA-003; intron 4

  OTTHUMT00000313799 ; IL31RA-005; intron 5

  OTTHUMT00000313796 ; IL31RA-002; intron 6

  ENST00000297015 ; IL31RA-201; intron 3

  ENST00000396836 ; IL31RA-004; intron 4

  ENST00000447346 ; IL31RA-001; intron 4

  ENST00000359040 ; IL31RA-003; intron 4

  ENST00000354961 ; IL31RA-202; intron 4

  ENST00000490985 ; IL31RA-005; intron 5

  ENST00000396834 ; IL31RA-002; intron 6

Clustered miRNAs

< 10kb from hsa-mir-449b

• hsa-mir-449c: chr5: 55172262-55172353 [-]
• hsa-mir-449b: chr5: 55170646-55170742 [-]
• hsa-mir-449a: chr5: 55170532-55170622 [-]

Database links

• EntrezGene:MIR449B
• HGNC:MIR449B
• RNAcentral:URS000075B9B1_9606
• miRBase Tracker:MI0003673

Mature sequence hsa-miR-449b-5p

• Accession: MIMAT0003327
• Previous IDs: hsa-miR-449b
• Sequence: 16 - aggcaguguauuguuagcuggc - 37
• Deep sequencing: 11218 reads, 96 experiments
• Evidence: experimental; Microarray [1], RT-PCR [1], SAGE [1], cloned [2]
• Database links:
  • RNAcentral:URS00003758F0_9606
• Predicted targets:
  • TargetMiner:hsa-miR-449b-5p
  • TargetScanVert:hsa-miR-449b-5p
  • miRDB:hsa-miR-449b-5p
  • microrna.org:hsa-miR-449b-5p

Mature sequence hsa-miR-449b-3p

• Accession: MIMAT0009203
• Previous IDs: hsa-miR-449b*
• Sequence: 55 - cagccacaacuacccugccacu - 76
• Deep sequencing: 91 reads, 29 experiments
• Evidence: experimental; 454 [3]
• Predicted targets:
  • TargetMiner:hsa-miR-449b-3p
  • TargetScanVert:hsa-miR-449b-3p
  • miRDB:hsa-miR-449b-3p
  • microrna.org:hsa-miR-449b-3p

References

1. PMID:16505370 "The colorectal microRNAome" Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE Proc Natl Acad Sci U S A. 103:3687-3692(2006).
2. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
3. PMID:19144710 "Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas" Zhu JY, Pfuhl T, Motsch N, Barth S, Nicholls J, Grasser F, Meister G J Virol. 83:3333-3341(2009).