miRBase entry: hsa-mir-653

Stem-loop hsa-mir-653


Accession
MI0003674
Symbol
HGNC: MIR653
Description
Homo sapiens hsa-mir-653 precursor miRNA
Gene family
MIPF0000435; mir-653

Literature search
8 open access papers mention hsa-mir-653
(9 sentences)

Sequence

733 reads, 29 reads per million, 53 experiments
uucauuccuucaGUGUUGAAACAAUCUCUACUGaaccagcuucaaacaagUUCACUGGAGUUUGUUUCAAUAuugcaagaaugauaagauggaagc
.((((((...((((((((((((((.(((((.(((((.............))))).))))).))))))))))))))...))))))............

Structure
-----------u      cuu              U     C     cagcu 
            ucauuc   caGUGUUGAAACAA CUCUA UGaac     u
            ||||||   |||||||||||||| ||||| |||||     c
            aguaag   guuAUAACUUUGUU GAGGU ACUUg     a
cgaagguagaau      aac              U     C     aacaa 


Annotation confidence High
Do you think this miRNA is real?
Comments
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr7: 93482760-93482855 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-653
Name Accession Chromosome Start End Strand Confidence




Disease association
hsa-mir-653 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-653-5p

Accession MIMAT0003328
Description Homo sapiens hsa-miR-653-5p mature miRNA
Sequence 13 - GUGUUGAAACAAUCUCUACUG - 33
Evidence experimental
SAGE [1], cloned [2], Illumina [3]
Database links
Predicted targets

Mature hsa-miR-653-3p

Accession MIMAT0026625
Description Homo sapiens hsa-miR-653-3p mature miRNA
Sequence 51 - UUCACUGGAGUUUGUUUCAAUA - 72
Evidence experimental
Illumina [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16505370
    The colorectal microRNAome
    "Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, Sjoblom T, Barad O, Bentwich Z, Szafranska AE, Labourier E, Raymond CK, Roberts BS, Juhl H, Kinzler KW, Vogelstein B, Velculescu VE"
    "Proc Natl Acad Sci U S A (2006) 103:3687-3692

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45