miRBase entry: hcmv-mir-US4

Stem-loop hcmv-mir-US4

Accession

MI0003687

Description

Human cytomegalovirus hcmv-mir-US4 precursor miRNA

Sequence

cgugucgcgacaUGGACGUGCAGGGGGAUGUCUGucgcgauagaguugaugUGACAGCCCGCUACACCUCUcugucgcgacaug
((((((((((((.(((.(((.((.(((....((((((((.((....)).))))))))))).)).))).))).))))))))))))

Structure

            U   C   C  G   AUGU        a  g 
cgugucgcgaca GGA GUG AG GGG    CUGucgcg ua a
|||||||||||| ||| ||| || |||    |||||||| ||  
guacagcgcugu UCU CAC UC CCC    GACAGUgu gu g
            c   C   A  G   ----        a  u

Annotation confidence Not enough data

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Genome context

HEHCMVCG: 195149-195232 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from hcmv-mir-US4

Name	Accession	Chromosome	Start	End	Strand	Confidence

Disease association

hcmv-mir-US4 is associated with one or more human diseases in the Human microRNA Disease Database

Disease	Description	Category	PubMed ID

Database links

Mature hcmv-miR-US4-5p

Accession	MIMAT0003341
Description	Human cytomegalovirus hcmv-miR-US4-5p mature miRNA
Sequence	13 - UGGACGUGCAGGGGGAUGUCUG - 34
Evidence	experimental Northern [1], Illumina [2-3]

Mature hcmv-miR-US4-3p

Accession	MIMAT0026628
Description	Human cytomegalovirus hcmv-miR-US4-3p mature miRNA
Sequence	52 - UGACAGCCCGCUACACCUCU - 71
Evidence	experimental Illumina [3]

References

PubMed ID: 16140786
Identification and characterization of human cytomegalovirus-encoded microRNAs
"Grey F, Antoniewicz A, Allen E, Saugstad J, McShea A, Carrington JC, Nelson J"
"J Virol (2005) 79:12095-12099

PubMed ID: 22013051
High-resolution profiling and analysis of viral and host small RNAs during human cytomegalovirus infection
"Stark TJ, Arnold JD, Spector DH, Yeo GW"
"J Virol (2012) 86:226-235

PubMed ID: 22715351
The microRNA Transcriptome of Human Cytomegalovirus (HCMV)
"Meshesha MK, Veksler-Lublinsky I, Isakov O, Reichenstein I, Shomron N, Kedem K, Ziv-Ukelson M, Bentwich Z, Avni YS"
"Open Virol J (2012) 6:38-48