Accession
MI0003757
Symbol
HGNC:
MIR758
Description
Homo sapiens
hsa-mir-758 precursor miRNA
Gene family
MIPF0000126;
mir-379
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR758 is a specific candidate microRNA that has been shown to inhibit the expression or function of ABCA1 [PMC6100038]. Treatment with 1m for 24 h was found to reduce the expression of MIR758, along with other microRNAs such as miR155, miR10b, miR145, miR33, and miR106b [PMC6100038]. Additionally, MIR758 was detected as one of the significantly changed microRNAs in various conditions and diseases such as endometrial, prostate, and breast carcinoma [PMC9866967]. It has also been associated with cell proliferation and differentiation control and neuroblastoma progression [PMC9866967]. Furthermore, in a genomic analysis using the dog reference genome CanFam3.1, MIR758 was found to be one of the strongly differentially expressed microRNAs in a specific region [PMC8376273]. The cluster containing MIR758 also included other microRNAs such as miR134, miR154, miR369, and miR655 [PMC10148110]. Overall, MIR758 is a candidate microRNA that has been implicated in various biological processes and diseases. It is involved in regulating ABCA1 expression or function and has been associated with cell proliferation control and neuroblastoma progression. Additionally, its differential expression has been observed in different conditions using genomic analysis.
Literature search
14 open access papers mention hsa-mir-758
(44 sentences)
(44 sentences)
Sequence
729
reads,
57
reads per million, 48 experiments
gccuggauacaugaGAUGGUUGACCAGAGAGCACACgcuuuauuugugccgUUUGUGACCUGGUCCACUAACCcucaguaucuaaugc
...(((((((.((((.((((.((((((.(.(((.((((.........).))).)))..))))))).))))...)))))))))))....
...(((((((.((((.((((.((((((.(.(((.((((.........).))).)))..))))))).))))...)))))))))))....
Structure
-gcc a --A U A -A C - uuu
uggauac ugaG UGGU GACCAG G GCA ACg c a
||||||| |||| |||| |||||| | ||| ||| | u
aucuaug acuc AUCA CUGGUC C UGU Ugc g u
cgua - CCA C - AG U c ugu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 101026020-101026107 [+]
Clustered miRNAs
12 other miRNAs are < 10 kb from hsa-mir-758
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-758 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-758-3p
| Accession | MIMAT0003879 |
| Description | Homo sapiens hsa-miR-758-3p mature miRNA |
| Sequence | 52 - UUUGUGACCUGGUCCACUAACC - 73 |
| Evidence |
experimental
cloned [1-2], SOLiD [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-758-5p
| Accession | MIMAT0022929 |
| Description | Homo sapiens hsa-miR-758-5p mature miRNA |
| Sequence | 15 - GAUGGUUGACCAGAGAGCACAC - 36 |
| Evidence |
experimental
SOLiD [3] |
| Database links |
|
| Predicted targets |
|
References
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