Stem-loop sequence xtr-mir-34b-4

AccessionMI0004818
DescriptionXenopus tropicalis miR-34b-4 stem-loop
Gene family MIPF0000039; mir-34
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-34_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The mir-34 microRNA precursor family are non-coding RNA molecules that, in mammals, give rise to three major mature miRNAs. The miR-34 family members were discovered computationally and later verified experimentally. The precursor miRNA stem-loop is processed in the cytoplasm of the cell, with the predominant miR-34 mature sequence excised from the 5' arm of the hairpin. The mature miR-34a is a part of the p53 tumor suppressor network; therefore, it is hypothesized that miR-34 dysregulation is involved in the development of some cancers.

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Stem-loop
   --uuca  c   g       c        uuaua 
5'       gg agu uaguuag ugauugug     u
         || ||| ||||||| ||||||||      
3'       cc uca aucgauc acuaacgu     c
   aaaaua  a   a       -        uuaaa 
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Confidence
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL173762.1: 13645-13711 [+]
intergenic
Clustered miRNAs
< 10kb from xtr-mir-34b-4
xtr-mir-34b-3GL173762.1: 6029-6113 [-]
xtr-mir-34b-4GL173762.1: 13645-13711 [+]

Mature sequence xtr-miR-34b

Accession MIMAT0003579
Sequence

3 - 

caggcaguguaguuagcugauug

 - 25

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Evidence by similarity; MI0003690
Predicted targets