Stem-loop sequence xtr-mir-181a-1

AccessionMI0004865
DescriptionXenopus tropicalis miR-181a-1 stem-loop
Gene family MIPF0000007; mir-181
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-181_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology miR-181 microRNA precursor is a small non-coding RNA molecule. MicroRNAs (miRNAs) are transcribed as ~70 nucleotide precursors and subsequently processed by the RNase-III type enzyme Dicer to give a ~22 nucleotide mature product. In this case the mature sequence comes from the 5' arm of the precursor. They target and modulate protein expression by inhibiting translation and / or inducing degradation of target messenger RNAs. This new class of genes has recently been shown to play a central role in malignant transformation. miRNA are downregulated in many tumors and thus appear to function as tumor suppressor genes. The mature products miR-181a, miR-181b, miR-181c or miR-181d are thought to have regulatory roles at posttranscriptional level, through complementarity to target mRNAs. miR-181 which has been predicted or experimentally confirmed in a wide number of vertebrate species as rat, zebrafish, and in the pufferfish (see below) (MIPF0000007).

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Stem-loop
   --   --ua  u     a   u      cu       a     g au 
5'   ggc    cu uagug aca ucaacg  gucggug guuug u  c
     |||    || ||||| ||| ||||||  ||||||| ||||| |  u
3'   ccg    gg auuac ugu aguugc  uagcuac caaac g  a
   ga   uaac  c     a   c      --       -     g aa 
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Confidence
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL172655.1: 4185417-4185506 [+]
intergenic
Clustered miRNAs
< 10kb from xtr-mir-181a-1
xtr-mir-181a-1GL172655.1: 4185417-4185506 [+]
xtr-mir-181b-1GL172655.1: 4185876-4185958 [+]

Mature sequence xtr-miR-181a-5p

Accession MIMAT0003625
Previous IDsxtr-miR-181a
Sequence

14 - 

aacauucaacgcugucggugagu

 - 36

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Evidence experimental; Northern [1]
Predicted targets

Mature sequence xtr-miR-181a-1-3p

Accession MIMAT0003626
Previous IDsxtr-miR-181a*;xtr-miR-181a-1*
Sequence

54 - 

accaucgaucguugacuguaca

 - 75

Get sequence
Evidence by similarity; MI0000289

References

1