Stem-loop sequence xtr-mir-181a-2

AccessionMI0004866 (change log)
DescriptionXenopus tropicalis miR-181a-2 stem-loop
Gene family MIPF0000007; mir-181
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-181_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology miR-181 microRNA precursor is a small non-coding RNA molecule. MicroRNAs (miRNAs) are transcribed as ~70 nucleotide precursors and subsequently processed by the RNase-III type enzyme Dicer to give a ~22 nucleotide mature product. In this case the mature sequence comes from the 5' arm of the precursor. They target and modulate protein expression by inhibiting translation and / or inducing degradation of target messenger RNAs. This new class of genes has recently been shown to play a central role in malignant transformation. miRNA are downregulated in many tumors and thus appear to function as tumor suppressor genes. The mature products miR-181a, miR-181b, miR-181c or miR-181d are thought to have regulatory roles at posttranscriptional level, through complementarity to target mRNAs. miR-181 which has been predicted or experimentally confirmed in a wide number of vertebrate species as rat, zebrafish, and in the pufferfish (see below) (MIPF0000007).

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   uu           a a   u      cu       a     agaaagu 
5'   gagggcuucag g aca ucaacg  gucggug guuug       g
     ||||||||||| | ||| ||||||  ||||||| |||||        
3'   uuuucggaguc c ugu aguugc  cggcuac caaau       u
   ac           c a   c      --       -     auaaaaa 
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Genome context
Coordinates (Xenopus_tropicalis_v9.1; GCA_000004195.3) Overlapping transcripts
KV460364.1: 1377155-1377249 [+]
Clustered miRNAs
< 10kb from xtr-mir-181a-2
xtr-mir-181a-2KV460364.1: 1377155-1377249 [+]
xtr-mir-181b-2KV460364.1: 1381322-1381404 [+]
Database links

Mature sequence xtr-miR-181a-5p

Accession MIMAT0003625
Previous IDsxtr-miR-181a

16 - 


 - 38

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Evidence experimental; Northern [1]
Predicted targets

Mature sequence xtr-miR-181a-2-3p

Accession MIMAT0005461
Previous IDsxtr-miR-181a-2*

61 - 


 - 82

Get sequence
Evidence by similarity; MI0000289
Predicted targets