Stem-loop sequence xtr-mir-218-1

AccessionMI0004871
DescriptionXenopus tropicalis miR-218-1 stem-loop
Gene family MIPF0000026; mir-218
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-218_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-218 microRNA precursor is a small non-coding RNA that regulates gene expression by antisense binding. miR-218 appears to be a vertebrate specific microRNA and has now been predicted and experimentally confirmed in a wide range of vertebrate species. The extents of the hairpin precursors are not known. In this case the mature sequence in excised from the 5'arm of the hairpin. miR-218, along with miR-585, has been found to be silenced by DNA methylation in oral squamous cell carcinoma. It is also downregulated in Nasopharyngeal carcinoma, with artificially-induced expression serving to slow tumour growth. miR-218 has also been found to have tumour suppressing qualities in bladder cancer cells.

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Stem-loop
   ug   ac   --   a   u      u         cu        gguugugag 
5'   gua  aag  gcg gau uucugu gugcuugau  aaccaugu         g
     |||  |||  ||| ||| |||||| |||||||||  ||||||||          
3'   cau  uuc  cgc cug aaggua cacgaacug  uugguaca         u
   -a   cu   ga   a   c      c         uc        aaaugagua 
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Confidence
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL172867.1: 380388-380496 [+]
sense
ENSXETT00000044254 ; slit2-201; intron 11

Mature sequence xtr-miR-218

Accession MIMAT0003631
Sequence

24 - 

uugugcuugaucuaaccaugu

 - 44

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Evidence by similarity; MI0002052
Predicted targets