Stem-loop sequence xtr-mir-301-1

AccessionMI0004876
DescriptionXenopus tropicalis miR-301-1 stem-loop
Gene family MIPF0000034; mir-130
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-130_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408), and in human (MI0000448, MI0000748). miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma. It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.

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Stem-loop
        aa   --     c    ---u          ----a       
5' cugcu  ugu  gugcu ugac    uuauugcacu     cuguac 
   |||||  |||  ||||| ||||    ||||||||||     ||||| u
3' gacga  acg  uacga acug    gauaacguga     gacaua 
        --   uc     a    uuau          cgauc       
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Confidence
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL172728.1: 2370001-2370084 [-]
intergenic
Clustered miRNAs
< 10kb from xtr-mir-301-1
xtr-mir-130aGL172728.1: 2370211-2370293 [-]
xtr-mir-301-1GL172728.1: 2370001-2370084 [-]

Mature sequence xtr-miR-301

Accession MIMAT0003635
Sequence

50 - 

cagugcaauaguauugucaaagc

 - 72

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Evidence by similarity; MI0002062
Predicted targets