Stem-loop sequence xtr-mir-301-2

DescriptionXenopus tropicalis miR-301-2 stem-loop
Gene family MIPF0000034; mir-130
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-130_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology, miR-130 microRNA precursor is a small non-coding RNA that regulates gene expression. This microRNA has been identified in mouse (MI0000156, MI0000408), and in human (MI0000448, MI0000748). miR-130 appears to be vertebrate-specific miRNA and has now been predicted or experimentally confirmed in a range of vertebrate species (MIPF0000034). Mature microRNAs are processed from the precursor stem-loop by the Dicer enzyme. In this case, the mature sequence is excised from the 3' arm of the hairpin. It has been found that miR-130 is upregulated in a type of cancer called hepatocellular carcinoma. It has been shown that miR-130a is expressed in the hematopoietic stem/progenitor cell compartment but not in mature blood cells.

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   --   u    c       ---        a  ----g  a 
5'   gaa ugcu ugacagu   guugcacu cu     ug u
     ||| |||| |||||||   |||||||| ||     ||  
3'   cuu acga acuguua   uaacguga ga     ac c
   ua   u    a       uga        c  aguaa  u 
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL172648.1: 3569092-3569164 [+]
Clustered miRNAs
< 10kb from xtr-mir-301-2
xtr-mir-130cGL172648.1: 3568249-3568319 [+]
xtr-mir-301-2GL172648.1: 3569092-3569164 [+]
xtr-mir-130bGL172648.1: 3575983-3576058 [+]

Mature sequence xtr-miR-301

Accession MIMAT0003635

44 - 


 - 66

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Evidence by similarity; MI0002062
Predicted targets