Stem-loop sequence xtr-let-7c

AccessionMI0004886 (change log)
DescriptionXenopus tropicalis let-7c stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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Stem-loop
   u   u  a      uu   g   u            uuagaa    a    
5'  gug gc uccagg  gag uag agguuguauggu      ugac ccc 
    ||| || ||||||  ||| ||| ||||||||||||      |||| || u
3'  cac cg agguuc  uuc auc uccaacauguca      auug ggg 
   u   u  -      cu   g   u            ------    a    
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Confidence
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Genome context
Coordinates (Xenopus_tropicalis_v9.1; GCA_000004195.3) Overlapping transcripts
chr2: 23121720-23121813 [+]
intergenic
Clustered miRNAs
< 10kb from xtr-let-7c
xtr-mir-99chr2: 23121034-23121104 [+]
xtr-let-7cchr2: 23121720-23121813 [+]
Database links

Mature sequence xtr-let-7c

Accession MIMAT0003644
Sequence

16 - 

ugagguaguagguuguaugguu

 - 37

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Evidence experimental; Northern [1]
Predicted targets

References

1