Stem-loop sequence xtr-mir-24b

AccessionMI0004896 (change log)
DescriptionXenopus tropicalis miR-24b stem-loop
Gene family MIPF0000041; mir-24
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-24_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-24 microRNA precursor is a small non-coding RNA molecule that regulates gene expression. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from the 3' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. miR-24 is conserved in various species, and is clustered with miR-23 and miR-27, on human chromosome 9 and 19. Recently, miR-24 has been shown to suppress expression of two crucial cell cycle control genes, E2F2 and Myc in hematopoietic differentiation and also to promote keratinocyte differentiation by repressing actin-cytoskeleton regulators PAK4, Tsk5 and ArhGAP19.

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       c  a   a         uaa    u  uua 
5' cucc gu ccu cugggcuga   ucag gg   u
   |||| || ||| |||||||||   |||| ||   a
3' gagg ca gga gacuugacu   gguc cc   u
       a  -   c         --c    c  uuc 
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Genome context
Coordinates (Xenopus_tropicalis_v9.1; GCA_000004195.3) Overlapping transcripts
chr3: 129999414-129999481 [+]
Clustered miRNAs
< 10kb from xtr-mir-24b
xtr-mir-23a-1chr3: 129998670-129998747 [+]
xtr-mir-27achr3: 129999278-129999353 [+]
xtr-mir-24bchr3: 129999414-129999481 [+]
Database links

Mature sequence xtr-miR-24b

Accession MIMAT0003655

45 - 


 - 65

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Evidence by similarity; MI0000231
Predicted targets