Stem-loop sequence xtr-mir-103-1

DescriptionXenopus tropicalis miR-103-1 stem-loop
Gene family MIPF0000024; mir-103
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-103/107_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-103 microRNA precursor (homologous to miR-107), is a short non-coding RNA gene involved in gene regulation. miR-103 and miR-107 have now been predicted or experimentally confirmed in human. microRNAs are transcribed as ~70 nucleotide precursors and subsequently processed by the Dicer enzyme to give a ~22 nucleotide product. In this case the mature sequence comes from the 5' arm of the precursor. The mature products are thought to have regulatory roles through complementarity to mRNA. mir-103 and mir-107 were noted as being upregulated in obese mice and were subsequently found to have a key role in insulin sensitivity. This led to a suggestion that these microRNAs represent potential targets for the treatment of type 2 diabetes. mir-103 has also been linked with chronic pain and intestinal cell proliferation.

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   u     uu      --    u  u           c   u g a 
5'  ucuca  uccuuu  ggcu cu uacagugcugc uug u c u
    |||||  ||||||  |||| || ||||||||||| ||| | |  
3'  agagu  aggaag  ucgg ga auguuacgacg aac a g a
   -     cu      ua    -  c           -   u g u 
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL172974.1: 199629-199713 [-]
ENSXETT00000029925 ; pank3-201; intron 5

Mature sequence xtr-miR-103

Accession MIMAT0003663

52 - 


 - 74

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Evidence by similarity; MI0000588
Predicted targets