Stem-loop sequence xtr-let-7e-1

AccessionMI0004907 (change log)
DescriptionXenopus tropicalis let-7e-1 stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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   cc  g     u   gu          u     auugggccgcac 
5'   cu uggga gag  aguagguugu uaguu            c
     || ||||| |||  |||||||||| |||||            c
3'   ga auccu cuc  ucauccaaca aucaa            a
   gu  a     -   ug          c     gagaggguaacc 
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Database links

Mature sequence xtr-let-7e

Accession MIMAT0003666

11 - 


 - 32

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Evidence experimental; Northern [1]
Predicted targets