Stem-loop sequence xtr-let-7a

AccessionMI0004908 (change log)
DescriptionXenopus tropicalis let-7a stem-loop
Gene family MIPF0000002; let-7
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled let-7_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The Let-7 microRNA precursor was identified from a study of developmental timing in C. elegans, and was later shown to be part of a much larger class of non-coding RNAs termed microRNAs. miR-98 microRNA precursor from human is a let-7 family member. Let-7 miRNAs have now been predicted or experimentally confirmed in a wide range of species (MIPF0000002). miRNAs are initially transcribed in long transcripts (up to several hundred nucleotides) called primary miRNAs (pri-miRNAs), which are processed in the nucleus by Drosha and Pasha to hairpin structures of about ~70 nucleotide. These precursors (pre-miRNAs) are exported to the cytoplasm by exportin5, where they are subsequently processed by the enzyme Dicer to a ~22 nucleotide mature miRNA. The involvement of Dicer in miRNA processing demonstrates a relationship with the phenomenon of RNA interference.

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   gu          cu       u              aggauaac 
5'   gggcuccagg  gagguag agguuguauaguug        a
     ||||||||||  ||||||| ||||||||||||||        c
3'   uucggggucc  uucuauc uccgacaugucaau        c
   --          cu       c              agaggaaa 
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Genome context
Coordinates (Xenopus_tropicalis_v9.1; GCA_000004195.3) Overlapping transcripts
chr7: 112714565-112714653 [+]
Clustered miRNAs
< 10kb from xtr-let-7a
xtr-mir-100chr7: 112711713-112711788 [+]
xtr-let-7achr7: 112714565-112714653 [+]
Database links

Mature sequence xtr-let-7a

Accession MIMAT0003667

14 - 


 - 35

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Evidence by similarity; MI0000828
Predicted targets