Stem-loop sequence xtr-mir-30c-2

AccessionMI0004919
DescriptionXenopus tropicalis miR-30c-2 stem-loop
Gene family MIPF0000005; mir-30
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-30_microRNA_precursor. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

miR-30 microRNA precursor is a small non-coding RNA that regulates gene expression. Animal microRNAs are transcribed as pri-miRNA (primary miRNA) of varying length which in turns are processed in the nucleus by Drosha into ~70 nucleotide stem-loop precursor called pre-miRNA (preliminary miRNA) and subsequently processed by the Dicer enzyme to give a mature ~22 nucleotide product. In this case the mature sequence comes from both the 3' (miR-30) and 5' (mir-97-6) arms of the precursor. The products are thought to have regulatory roles through complementarity to mRNA. A screen of 17 miRNAs that have been predicted to regulate a number of breast cancer associated genes found variations in the microRNAs miR-17 and miR-30c-1, these patients were noncarriers of BRCA1 or BRCA2 mutations, lending the possibility that familial breast cancer may be caused by variation in these miRNAs. Members of the miR-30 family have been found to be highly expressed in heart cells.

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Stem-loop
   --      cagauacu       u   aca         g  ga 
5'   gagaga        guaaaca ccu   cucucagcu ug  a
     ||||||        ||||||| |||   ||||||||| ||   
3'   cucucu        cauuugu gga   gggggucga ac  a
   gu      --------       c   --a         a  au 
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Confidence
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL172904.1: 1398963-1399040 [+]
intergenic
Clustered miRNAs
< 10kb from xtr-mir-30c-2
xtr-mir-30aGL172904.1: 1391566-1391636 [+]
xtr-mir-30c-2GL172904.1: 1398963-1399040 [+]

Mature sequence xtr-miR-30c

Accession MIMAT0003577
Sequence

14 - 

uguaaacauccuacacucucagc

 - 36

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Evidence by similarity; MI0000871
Predicted targets