Stem-loop sequence xtr-mir-34b-1

AccessionMI0004925 (change log)
DescriptionXenopus tropicalis miR-34b-1 stem-loop
Gene family MIPF0000039; mir-34
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-34_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The mir-34 microRNA precursor family are non-coding RNA molecules that, in mammals, give rise to three major mature miRNAs. The miR-34 family members were discovered computationally and later verified experimentally. The precursor miRNA stem-loop is processed in the cytoplasm of the cell, with the predominant miR-34 mature sequence excised from the 5' arm of the hairpin. The mature miR-34a is a part of the p53 tumor suppressor network; therefore, it is hypothesized that miR-34 dysregulation is involved in the development of some cancers.

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Stem-loop
   u   g      - a  c   g       c       --   aa 
5'  guu gguuuu c gg agu uaguuag ugauugu  guu  c
    ||| |||||| | || ||| ||||||| |||||||  |||  a
3'  caa ucaaaa g cc uca aucgauc acuaacg  cag  u
   a   a      c a  a   a       -       uu   aa 
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Confidence
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Genome context
Coordinates (Xenopus_tropicalis_v9.1; GCA_000004195.3) Overlapping transcripts
chr7: 75066349-75066433 [+]
intergenic
Clustered miRNAs
< 10kb from xtr-mir-34b-1
xtr-mir-34b-2chr7: 75059637-75059703 [-]
xtr-mir-34b-1chr7: 75066349-75066433 [+]
Database links

Mature sequence xtr-miR-34b

Accession MIMAT0003579
Sequence

12 - 

caggcaguguaguuagcugauug

 - 34

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Evidence by similarity; MI0003690
Predicted targets