Stem-loop sequence xtr-mir-200a

AccessionMI0004945 (change log)
DescriptionXenopus tropicalis miR-200a stem-loop
Gene family MIPF0000019; mir-8
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-8/mir-141/mir-200_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-8 microRNA precursor (homologous to miR-141, miR-200, miR-236), is a short non-coding RNA gene involved in gene regulation. miR-8 in Drosophila melanogaster is expressed from the 3' arm of related precursor hairpins (represented here), along with miR-200, miR-236, miR-429 and human and mouse homolog miR-141. Members of this precursor family have now been predicted or experimentally confirmed in a wide range of species. The bounds of the precursors are predicted based on conservation and base pairing and are not generally known. The miR-200 family is highly conserved in bilaterian animals, with miR-8 as the sole homolog in Drosophila. This species has accordingly been used heavily in work looking to uncover the biological function of the miR-200 family. miR-8 has been observed at all developmental stages of the embryo, with a complete absence from cultured S2 cells of D. melanogaster. Its expression has been seen to be strongly upregulated in larvae and this expression then sustained through to adulthood.

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   u  -  -    a        -             c    uuuauu 
5'  gg uc cucu uggacauc uuacuagacagug ugga      u
    || || |||| |||||||| ||||||||||||| ||||       
3'  cc ag gaga auuuguag aauggucugucac aucu      u
   a  g  u    a        c             a    uuucua 
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Genome context
Coordinates (Xenopus_tropicalis_v9.1; GCA_000004195.3) Overlapping transcripts
chr7: 78800601-78800689 [-]
Clustered miRNAs
< 10kb from xtr-mir-200a
xtr-mir-200bchr7: 78802277-78802365 [-]
xtr-mir-200achr7: 78800601-78800689 [-]
xtr-mir-429chr7: 78797776-78797862 [-]
Database links

Mature sequence xtr-miR-200a

Accession MIMAT0003693

53 - 


 - 74

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Evidence experimental; Northern [1]
Predicted targets