Stem-loop sequence xtr-mir-205a

AccessionMI0004950
DescriptionXenopus tropicalis miR-205a stem-loop
Gene family MIPF0000058; mir-205
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-205. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology miR-205 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. They are involved in numerous cellular processes, including development, proliferation, and apoptosis. Currently, it is believed that miRNAs elicit their effect by silencing the expression of target genes. The miR-200 family (miR-200a, miR-200b, miR-200c, miR-141 and miR-429) and miR-205 are frequently silenced in advanced cancer. Studies has shown that -- by targeting the transcriptional repressors of E-cadherin, ZEB1 and ZEB2-- Mir-205 is involved in epithelial to mesenchymal transition (EMT) and tumor invasion[citation needed]. Recently, miR-200 silencing was also reported in cancer stem cells, implying that miR-200 deregulation is a key event in multiple levels of tumor biology. The cause of miR-200 silencing in naturally-occurring cancer cells, however, remains largely unknown.

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Stem-loop
   cc     u   gc   c           c        ucuca 
5'   acgug ccu  ugu cuucauuccac ggagucug     u
     ||||| |||  ||| ||||||||||| ||||||||     a
3'   uguac gga  aca gaagugaggug cuuuagac     c
   ga     -   ga   c           a        uaaua 
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Confidence
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL172697.1: 840372-840457 [+]
intergenic

Mature sequence xtr-miR-205a

Accession MIMAT0003697
Sequence

16 - 

uccuucauuccaccggagucug

 - 37

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Evidence by similarity; MI0000248
Predicted targets