Stem-loop sequence xtr-mir-221

AccessionMI0004953 (change log)
DescriptionXenopus tropicalis miR-221 stem-loop
Gene family MIPF0000051; mir-221
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled Mir-221_microRNA. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

In molecular biology mir-221 microRNA (and its paralogue, mir-222) is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms. mir-221 is an oncogenic microRNA. It targets CD117, which then prevents cell migration and proliferation in endothelial cells. miR-221 is known as an anti angiogenic miRNA. Recent important studies have reported that miR-221 is also involved in induction of angiogenesis. RNA induced Silencing Complex (RISC) proteins SND1 and AEG-1 induces miR-221 expression in Liver cancer. In liver cancer miR-221 induces the tumor angiogenesis.

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   ac   gac  ug     -c   ug   u         aaaa    -   u 
5'   cca   uu  gcgug  acc  gca acaauguag    cugu guu g
     |||   ||  |||||  |||  ||| |||||||||    |||| ||| c
3'   ggu   aa  cguac  ugg  cgu uguuacauc    gaca cga a
   -a   ---  gu     uu   gu   c         ----    a   a 
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Genome context
Coordinates (Xenopus_tropicalis_v9.1; GCA_000004195.3) Overlapping transcripts
chr2: 68930805-68930897 [+]
Clustered miRNAs
< 10kb from xtr-mir-221
xtr-mir-222chr2: 68930297-68930360 [+]
xtr-mir-221chr2: 68930805-68930897 [+]
Database links

Mature sequence xtr-miR-221

Accession MIMAT0003700

59 - 


 - 81

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Evidence by similarity; MI0000961
Predicted targets