Stem-loop sequence xtr-mir-429

AccessionMI0004956
DescriptionXenopus tropicalis miR-429 stem-loop
Gene family MIPF0000019; mir-8
Community annotation

This text is a summary paragraph taken from the Wikipedia entry entitled mir-8/mir-141/mir-200_microRNA_precursor_family. miRBase and Rfam are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...

The miR-8 microRNA precursor (homologous to miR-141, miR-200, miR-236), is a short non-coding RNA gene involved in gene regulation. miR-8 in Drosophila melanogaster is expressed from the 3' arm of related precursor hairpins (represented here), along with miR-200, miR-236, miR-429 and human and mouse homolog miR-141. Members of this precursor family have now been predicted or experimentally confirmed in a wide range of species. The bounds of the precursors are predicted based on conservation and base pairing and are not generally known. The miR-200 family is highly conserved in bilaterian animals, with miR-8 as the sole homolog in Drosophila. This species has accordingly been used heavily in work looking to uncover the biological function of the miR-200 family. miR-8 has been observed at all developmental stages of the embryo, with a complete absence from cultured S2 cells of D. melanogaster. Its expression has been seen to be strongly upregulated in larvae and this expression then sustained through to adulthood.

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Stem-loop
   u   u  -         u -          ag       cu  u 
5'  gcc gu ugaccaaug c uuaccagaca  guuagau  ag u
    ||| || ||||||||| | ||||||||||  |||||||  || a
3'  cgg ua acugguugc g aauggucugu  uaaucug  uc c
   -   u  c         c u          ca       -c  u 
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Confidence
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Genome context
Coordinates (JGI4.2) Overlapping transcripts
GL173621.1: 57232-57318 [+]
intergenic
Clustered miRNAs
< 10kb from xtr-mir-429
xtr-mir-200bGL173621.1: 52729-52817 [+]
xtr-mir-200aGL173621.1: 54405-54493 [+]
xtr-mir-429GL173621.1: 57232-57318 [+]

Mature sequence xtr-miR-429

Accession MIMAT0003703
Sequence

53 - 

uaauacugucugguaaugccgu

 - 74

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Evidence by similarity; MI0001643
Predicted targets