Accession
MI0004994
Description
Gallus gallus
gga-mir-21 precursor miRNA
Gene family
MIPF0000060;
mir-21
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Gga-mir-21 is a differentially expressed miRNA in chickens that has been studied in relation to its role in fighting against Infectious Bursal Disease Virus (IBDV) [PMC3700833]. To validate the Illumina small RNA deep sequencing data, five differentially expressed miRNAs, including gga-mir-21, were selected and their expression levels were quantified using real-time quantitative RT-PCR (qRT-PCR) [PMC3700833]. The study found that gga-mir-21 is upregulated in chickens as a defense mechanism against IBDV by inhibiting viral replication [PMC5097849]. This suggests that gga-mir-21 plays a role in the immune response to IBDV infection in chickens. The upregulation of gga-mir-21 may be a protective mechanism to limit viral replication and reduce the severity of the infection. This finding highlights the importance of miRNAs, such as gga-mir-21, in modulating immune responses and fighting against viral infections. Further research is needed to fully understand the mechanisms by which gga-mir-21 functions and its potential as a therapeutic target for IBDV infections [PMC5097849].
Literature search
31 open access papers mention gga-mir-21
(211 sentences)
(211 sentences)
Sequence
1933092
reads,
34970
reads per million, 5 experiments
uguaccauccugucggaUAGCUUAUCAGACUGAUGUUGAcuguuggaucucauggCAACAACAGUCGGUAGGCUGUCugacauuuugguaucucuca
.((((((...((((((((((((((((.(((((.(((((.((((........))))))))).)))))))))))))))))))))...))))))......
.((((((...((((((((((((((((.(((((.(((((.((((........))))))))).)))))))))))))))))))))...))))))......
Structure
-----u ucc A A A ugg
guacca ugucggaUAGCUUAUC GACUG UGUUG cugu a
|||||| |||||||||||||||| ||||| ||||| ||||
uauggu acaguCUGUCGGAUGG CUGAC ACAAC ggua u
acucuc uuu - A - cuc
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr19: 7376247-7376343 [+]
Database links
Mature gga-miR-21-5p
| Accession | MIMAT0003774 |
| Description | Gallus gallus gga-miR-21-5p mature miRNA |
| Sequence | 18 - UAGCUUAUCAGACUGAUGUUGA - 39 |
| Evidence |
experimental
cloned [1-2], Northern [1], Illumina [3] |
| Database links |
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| Predicted targets |
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Mature gga-miR-21-3p
| Accession | MIMAT0026643 |
| Description | Gallus gallus gga-miR-21-3p mature miRNA |
| Sequence | 56 - CAACAACAGUCGGUAGGCUGUC - 77 |
| Evidence |
experimental
Illumina [3] |
| Database links |
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| Predicted targets |
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References
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