Accession
MI0005540
Symbol
HGNC:
MIR889
Description
Homo sapiens
hsa-mir-889 precursor miRNA
Gene family
MIPF0000514;
mir-889
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR889 is a miRNA that belongs to the miR655 miRNA cluster, which contains a total of 20 miRNAs [PMC7465874]. Nine of these miRNAs, including MIR889, have available expression data [PMC7465874]. In the context of HCV and chronic HCV complications, several upregulated miRNAs have been identified, including MIR889 [PMC9495750]. The expression data for the miR655 cluster reveals that it contains 16 miRNAs [PMC10148110]. Cancer cells have mechanisms to evade immune surveillance and tumor cell-derived extracellular vesicles (EVs) play a role in transmitting immune-suppressive messages in the tumor microenvironment [PMC10114864]. EV-incorporated RNAs can help cancer cells evade immune responses and convey death signals to immune cells [PMC10114864]. In colorectal cancer, EV-miR203 is involved in cellular immunosuppression by activating M2-tumor-associated macrophages [PMC10114864]. Additionally, MIR889 triggers the downregulation of immune infiltration in colorectal cancer [PMC10114864]. In a study on dogs, several highly differentially expressed (DE) miRNAs were identified, including MIR889 [PMC8376273]. Overall, MIR889 is a member of the miR655 cluster and has been implicated in various aspects of cancer biology and immunosuppression.
Literature search
10 open access papers mention hsa-mir-889
(21 sentences)
(21 sentences)
Sequence
6883
reads,
80
reads per million, 77 experiments
gugcuuaaagAAUGGCUGUCCGUAGUAUGGUCucuauauuuaugaugaUUAAUAUCGGACAACCAUUGUuuuaguaucc
(((((.(((.(((((.((((((..((.(((((((.........)).)))))))..)))))).))))).))).)))))..
(((((.(((.(((((.((((((..((.(((((((.........)).)))))))..)))))).))))).))).)))))..
Structure
-- u g C UA A - uau gugcu aaa AAUGG UGUCCG GU UGGUC uc a ||||| ||| ||||| |||||| || ||||| || u uauga uuU UUACC ACAGGC UA AUUag ag u cc u G A UA - u uau
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr14: 101047901-101047979 [+]
Clustered miRNAs
19 other miRNAs are < 10 kb from hsa-mir-889
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-889 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-889-3p
| Accession | MIMAT0004921 |
| Description | Homo sapiens hsa-miR-889-3p mature miRNA |
| Sequence | 49 - UUAAUAUCGGACAACCAUUGU - 69 |
| Evidence |
experimental
cloned [1], Illumina [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-889-5p
| Accession | MIMAT0026719 |
| Description | Homo sapiens hsa-miR-889-5p mature miRNA |
| Sequence | 11 - AAUGGCUGUCCGUAGUAUGGUC - 32 |
| Evidence |
experimental
Illumina [2] |
References
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