Stem-loop hsa-mir-147b

Accession

MI0005544

Symbol

HGNC: MIR147B

Description

Homo sapiens hsa-mir-147b precursor miRNA

Gene family

MIPF0000105; mir-147

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-147b is a microRNA that has been found to be associated with rectum cancer [29]. In the presence of the CHRM3 gene, bile acid is likely to induce right-sided colon tumors and decrease the expression of hsa-mir-147b [PMC10152154]. Several effective pairings of microRNAs have been identified in different countries, including hsa-mir-1267, hsa-mir-325, hsa-mir-5683, and hsa-mir-3064-5p in China; hsa-mir-5197, hsa-mir-147b, hsa-mir-6874, hsa-mir-138-1, hsa-mir-664b, and hsa-mir1-3p in India; and hasmir1267, hasmir1381, hasmir664b and hasmir13p in Italy [PMC7395633]. These microRNA pairings have been found to have interactions with viral SARS-CoV2 miRNAs [PMC7395633]. In Jamaica specifically, there are three collective pairings of microRNAs involved with viral SARS-CoV2 miRNAs: hasmir1267, hasmir325 and hasmir5683 [PMC7395633]. These findings suggest that different microRNA pairings may play a role in cancer development and viral interactions in different populations. Further research is needed to understand the specific mechanisms involved.

Literature search

46 open access papers mention hsa-mir-147b
(358 sentences)

Sequence

1649 reads, 208 reads per million, 88 experiments

uauaaaucuagUGGAAACAUUUCUGCACAAACUagauucuggacaccaGUGUGCGGAAAUGCUUCUGCUacauuuuuagg
((.((((.((((((((.((((((((((((.........((((...)))))))))))))))).)))))))).)))).))..

Structure

--  u    c        A            AACUagauu    a 
  ua aaau uagUGGAA CAUUUCUGCACA         cugg  
  || |||| |||||||| ||||||||||||         |||| c
  au uuua aUCGUCUU GUAAAGGCGUGU         Gacc  
gg  u    c        C            ---------    a 

Annotation confidence High

Genome context

chr15: 45433050-45433129 [+]

Disease association

hsa-mir-147b is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-147b-3p

• Accession: MIMAT0004928
• Description: Homo sapiens hsa-miR-147b-3p mature miRNA
• Sequence: 49 - GUGUGCGGAAAUGCUUCUGCU - 69
• Evidence: experimental ; cloned [1]

Mature hsa-miR-147b-5p

• Accession: MIMAT0037331
• Description: Homo sapiens hsa-miR-147b-5p mature miRNA
• Sequence: 12 - UGGAAACAUUUCUGCACAAACU - 33
• Evidence: not_experimental

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414