Stem-loop sequence mmu-mir-466d

Accession

MI0005546

Symbol

MGI:Mir466d

Description

Mus musculus miR-466d stem-loop

Gene family

MIPF0000316; mir-467

Stem-loop

--ca       u            - -    --a a            aa 
    ugugugu ugugugugcgua c augu   c uguguguauaug  u
    ||||||| |||||||||||| | ||||   | ||||||||||||   
    acacaca acacgcacgcau g uaca   g acauacauauac  a
ggac       c            a a    cac c            au 

Deep sequencing

5486 reads, 83 experiments

Comments

miR-466d-3p reported in [1] has an additional 3' U base which is inconsistent with the current genome sequence (as shown here).

Genome context

• Coordinates (GRCm38): chr2: 10511967-10512062 [+]
• Overlapping transcripts:

  sense

  OTTMUST00000026263 ; Sfmbt2-001; intron 10

  ENSMUST00000041105 ; Sfmbt2-001; intron 10

  ENSMUST00000116594 ; Sfmbt2-201; intron 11

Clustered miRNAs

< 10kb from mmu-mir-466d

• mmu-mir-467a-10: chr2: 10503273-10503355 [+]
• mmu-mir-466b-3: chr2: 10503565-10503645 [+]
• mmu-mir-669a-12: chr2: 10503791-10503877 [+]
• mmu-mir-467e: chr2: 10505721-10505807 [+]
• mmu-mir-466p: chr2: 10506006-10506094 [+]
• mmu-mir-467d: chr2: 10507630-10507714 [+]
• mmu-mir-466a: chr2: 10507918-10507990 [+]
• mmu-mir-297c: chr2: 10509016-10509113 [+]
• mmu-mir-669c: chr2: 10509296-10509404 [+]
• mmu-mir-669a-2: chr2: 10510164-10510260 [+]
• mmu-mir-297b: chr2: 10511667-10511775 [+]
• mmu-mir-466d: chr2: 10511967-10512062 [+]
• mmu-mir-669m-1: chr2: 10512790-10512887 [+]
• mmu-mir-669m-2: chr2: 10513434-10513531 [+]
• mmu-mir-466n: chr2: 10513741-10513834 [+]
• mmu-mir-669o: chr2: 10514300-10514395 [+]
• mmu-mir-466g: chr2: 10514595-10514674 [+]
• mmu-mir-466h: chr2: 10514891-10514971 [+]
• mmu-mir-297a-3: chr2: 10515820-10515921 [+]
• mmu-mir-466l: chr2: 10516097-10516217 [+]
• mmu-mir-297a-4: chr2: 10517067-10517164 [+]
• mmu-mir-669i: chr2: 10517604-10517730 [+]
• mmu-mir-669h: chr2: 10518155-10518279 [+]

Database links

• ENTREZGENE: 100124465;Mir466d
• MGI: 3718531;Mir466d

Mature sequence mmu-miR-466d-5p

• Accession: MIMAT0004930
• Sequence: 11 - ugugugugcguacauguacaug - 32
• Deep sequencing: 764 reads, 50 experiments
• Evidence: experimental; cloned [1], Solexa [3-4]
• Predicted targets:
  • DIANA-MICROT:mmu-miR-466d-5p
  • MICRORNA.ORG:mmu-miR-466d-5p
  • MIRDB:mmu-miR-466d-5p
  • RNA22-MMU:mmu-miR-466d-5p
  • TARGETSCAN-VERT:mmu-miR-466d-5p

Mature sequence mmu-miR-466d-3p

• Accession: MIMAT0004931
• Sequence: 51 - uauacauacacgcacacauag - 71
• Deep sequencing: 4428 reads, 76 experiments
• Evidence: experimental; cloned [1], 454 [2], Solexa [3-4]
• Predicted targets:
  • DIANA-MICROT:mmu-miR-466d-3p
  • MICRORNA.ORG:mmu-miR-466d-3p
  • MIRDB:mmu-miR-466d-3p
  • RNA22-MMU:mmu-miR-466d-3p
  • TARGETSCAN-VERT:mmu-miR-466d-3p

References

1. PMID:17604727 "A mammalian microRNA expression atlas based on small RNA library sequencing" Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M Cell. 129:1401-1414(2007).
2. PMID:17989215 "RNA sequence analysis defines Dicer's role in mouse embryonic stem cells" Calabrese JM, Seila AC, Yeo GW, Sharp PA Proc Natl Acad Sci U S A. 104:18097-18102(2007).
3. PMID:20215419 "MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing" Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A Mol Hum Reprod. 16:463-471(2010).
4. PMID:20413612 "Mammalian microRNAs: experimental evaluation of novel and previously annotated genes" Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP Genes Dev. 24:992-1009(2010).