Stem-loop mmu-mir-208b

Accession

MI0005552

Symbol

MGI: Mir208b

Description

Mus musculus mmu-mir-208b precursor miRNA

Gene family

MIPF0000178; mir-208

Literature search

70 open access papers mention mmu-mir-208b
(206 sentences)

Sequence

1589 reads, 76 reads per million, 40 experiments

ccucucagggAAGCUUUUUGCUCGCGUUAUGUuucucauccgaauAUAAGACGAACAAAAGGUUUGUcugagggcug
.((((((((.((((((((((.(((..((((((((.......))))))))..))).)))))))))).))))))))...

Structure

--c        g          C   CG        cu 
   cucucagg AAGCUUUUUG UCG  UUAUGUuu  c
   |||||||| |||||||||| |||  ||||||||  a
   gggagucU UUUGGAAAAC AGC  AAUAuaag  u
guc        G          A   AG        cc 

Annotation confidence Not enough data

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr14: 54975700-54975776 [-]

Mature mmu-miR-208b-5p

• Accession: MIMAT0017280
• Description: Mus musculus mmu-miR-208b-5p mature miRNA
• Sequence: 11 - AAGCUUUUUGCUCGCGUUAUGU - 32
• Evidence: experimental ; Illumina [4]

Mature mmu-miR-208b-3p

• Accession: MIMAT0004939
• Description: Mus musculus mmu-miR-208b-3p mature miRNA
• Sequence: 46 - AUAAGACGAACAAAAGGUUUGU - 67
• Evidence: experimental ; cloned [2], 454 [3], Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


3. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


4. PubMed ID: 17989215
   RNA sequence analysis defines Dicer's role in mouse embryonic stem cells
   "Calabrese JM, Seila AC, Yeo GW, Sharp PA"
   "Proc Natl Acad Sci U S A (2007) 104:18097-18102