Stem-loop hsa-mir-877

Accession

MI0005561

Symbol

HGNC: MIR877

Description

Homo sapiens hsa-mir-877 precursor miRNA mir-877

Gene
family

RF00912; mir-877

Literature search

31 open access papers mention hsa-mir-877
(62 sentences)

Sequence

10072 reads, 170 reads per million, 97 experiments

GUAGAGGAGAUGGCGCAGGGgacacgggcaaagacuuggggguuccugggacccucagacgugugUCCUCUUCUCCCUCCUCCCAG
...((((((..((.(.((((((((((.(.......((((((((((...)))))))))).).)))))))))).).))))))))....

Structure

-GUA      AU  C C          g caaagac          c 
    GAGGAG  GG G AGGGgacacg g       uuggggguuc  
    ||||||  || | |||||||||| |       |||||||||| u
    CUCCUC  CC C UCUCCUgugu c       gacucccagg  
GACC      --  U U          g ------a          g 

Annotation confidence High

Comments

This sequence was identified as a miRNA candidate by Berezikov et al. using RAKE and MPSS techniques [1]. Expression was later confirmed by cloning [2].

Genome context

chr6: 30584332-30584417 [+]

Disease association

hsa-mir-877 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-877-5p

• Accession: MIMAT0004949
• Description: Homo sapiens hsa-miR-877-5p mature miRNA
• Sequence: 1 - GUAGAGGAGAUGGCGCAGGG - 20
• Evidence: experimental ; cloned [1-3]

Mature hsa-miR-877-3p

• Accession: MIMAT0004950
• Description: Homo sapiens hsa-miR-877-3p mature miRNA
• Sequence: 66 - UCCUCUUCUCCCUCCUCCCAG - 86
• Evidence: experimental ; cloned [1-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 16954537
   Many novel mammalian microRNA candidates identified by extensive cloning and RAKE analysis
   "Berezikov E, van Tetering G, Verheul M, van de Belt J, van Laake L, Vos J, Verloop R, van de Wetering M, Guryev V, Takada S, van Zonneveld AJ, Mano H, Plasterk R, Cuppen E"
   "Genome Res (2006) 16:1289-1298


3. PubMed ID: 17964270
   Mammalian mirtron genes
   "Berezikov E, Chung WJ, Willis J, Cuppen E, Lai EC"
   "Mol Cell (2007) 28:328-336