Accession
MI0006383
Symbol
HGNC:
MIR1248
Description
Homo sapiens
hsa-mir-1248 precursor miRNA
Gene family
MIPF0000622;
mir-1248
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR1248 is a microRNA that may target a specific isoform of OGG1 due to differences in mRNA 3′UTR regions [PMC9118907]. In stallion sperm, MIR1248 is one of six miRNAs that show very high expression levels [PMC3569414]. It has 154 target genes and is upregulated in SK-N-SH and K562 cells [PMC5600530]. The relationship between PSMD10 expression levels and MIR1248 has been investigated [PMC9414407]. In TamR cells, MIR1248 is slightly upregulated with moderate absolute expression levels, along with other miRNAs [PMC3402532]. In old hematopoietic stem cells (HSC), MIR1248 has been found to be regulated along with an inflammation mediator NFKBIA [PMC8296523]. After IFN-γ stimulation, MIR1248 is one of the top 10 upregulated miRNAs [PMC8010072]. MIR1248 is a microRNA that may target a specific isoform of OGG1 due to differences in mRNA 3′UTR regions. The majority of miRNAs (76%) showed high expression level (10 AC 100), 13 miRNAs (16%) had AC lower than 10, whereas 6 miRNAs-MIR34B, MIR34C, MIR191, MIR223, MIR1248, and MIR1905C-showed very high expression levels (AC≥100) in stallion sperm. It has been found to have 154 target genes and be upregulated in SK-N-SH and K562. The relationship between PSMD10 expression levels and MIR1248 has been investigated. In TamR cells it was found to be slightly upregulated with moderate absolute expression levels along with other miRNAs. In old HSC, MIR1248 has been found to be regulated along with an inflammation mediator NFKBIA. After IFN-γ stimulation, MIR1248 is one of the top 10 upregulated miRNAs.
Literature search
16 open access papers mention hsa-mir-1248
(61 sentences)
(61 sentences)
Sequence
1022
reads,
198
reads per million, 115 experiments
uuuACCUUCUUGUAUAAGCACUGUGCUAAAauugcagacacuaggaccaugucuugguuuuugcaauaaugcuagcagaguacacacaagaagaaaaguaacagca
.....((((((((....(.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).)..)))))))).............
.....((((((((....(.(((.(((((..((((((((.((((((((...)))))))).)))))))).....))))).))).)..)))))))).............
Structure
--------uuuAC AUAA C G ---AA c c
CUUCUUGU G ACU UGCUA auugcaga acuaggac
|||||||| | ||| ||||| |||||||| |||||||| a
gaagaaca c uga acgau uaacguuu ugguucug
acgacaaugaaaa --ca a g cguaa u u
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr3: 186786672-186786777 [+]
Disease association
hsa-mir-1248 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-1248
| Accession | MIMAT0005900 |
| Description | Homo sapiens hsa-miR-1248 mature miRNA |
| Sequence | 4 - ACCUUCUUGUAUAAGCACUGUGCUAAA - 30 |
| Evidence |
experimental
Illumina [1] |
| Database links |
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| Predicted targets |
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References
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