| Community annotation |
This text is a summary paragraph taken from the Wikipedia
entry entitled MiR-214. miRBase and Rfam
are facilitating community annotation of microRNA families and entries in Wikipedia. Read more ...
The text in this section is taken from the free, online
encyclopedia, Wikipedia. Anyone can edit a Wikipedia page. We hope
that experts on particular microRNA sequences will use the links to
Wikipedia below to edit the annotation of individual microRNAs, to add
information about function, evolution, discovery, and literature
references, for example. Any changes that you make will be visible in
Wikipedia immediately, and in miRBase within 24 hours.
Editing Wikipedia entries is straightforward. If you haven't
edited a page before, you might like to take a look at the following
Wikipedia help pages:
You can also create new pages at Wikipedia about microRNA families
that do not currently have specific entries there. Please let us know
if you do, so we can incorporate your annotation into miRBase, and
create the appropriate links from miRBase entries to the relevant
Wikipedia pages.
Please note, we're not responsible for the content of Wikipedia pages.
You can read more about miRBase, Wikipedia and community annotation on this blog post.
Please email us for
help or with comments about this community annotation initiative.
miR-214 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer. This sequence then associates with RISC which effects RNA interference.
Show Wikipedia entry
View @ Wikipedia
Edit Wikipedia entry
miR-214 is a family of microRNA precursors found in animals, including humans. The ~22 nucleotide mature miRNA sequence is excised from the precursor hairpin by the enzyme Dicer.[1] This sequence then associates with RISC which effects RNA interference.[2]
Function [edit]
miR-214 is a "melano-miR",[3] so-called because it is thought to encourage the metastasis of melanoma. Specifically, the mature microRNA excised from miR-214 is predicted to target two activating protein 2 transcription factors, bringing about downstream effects on a number of genes regulating vital cell cycle processes, such as apoptosis, proliferation and angiogenesis.[3]
miR-214 is also thought to regulate type-I collagen.[4]
Role in cancer [edit]
miR-214 has been found to be downregulated in human cervical cancer; when miR-214 was upregulated in HeLa cancer cells, it was found to significantly reduce cell growth.[5] Two mRNA targets were identified as those encoding the proteins MAP2K3 and MAPK8.[5]
The increased expression of miR-214 in pancreatic cancer could bring about increased resistance to chemotherapy.[6]
In human glioma cell line T98G expression of miR-214 has been shown to suppress expression of the ubiquitin-conjugating enzyme 9 (UBC9) and reduces tumour cell proliferation. The protein UBC9 is involved in the sumoylation pathway, and is up-regulated in many cancers.[7]
References [edit]
- ^ Ambros, V (2001-12-28). "microRNAs: tiny regulators with great potential.". Cell 107 (7): 823–6. doi:10.1016/S0092-8674(01)00616-X. PMID 11779458.
- ^ Gregory, RI; Chendrimada, TP, Cooch, N, Shiekhattar, R (2005-11-18). "Human RISC couples microRNA biogenesis and posttranscriptional gene silencing.". Cell 123 (4): 631–40. doi:10.1016/j.cell.2005.10.022. PMID 16271387.
- ^ a b Bar-Eli, M (2011-05-18). "Searching for the 'melano-miRs': miR-214 drives melanoma metastasis". The EMBO Journal 30 (10): 1880–1. doi:10.1038/emboj.2011.132. PMC 3098491. PMID 21593728.
- ^ Maubach, G; Lim, MC, Chen, J, Yang, H, Zhuo, L (2011-06-14). "miRNA studies in in vitro and in vivo activated hepatic stellate cells". World journal of gastroenterology : WJG 17 (22): 2748–73. doi:10.3748/wjg.v17.i22. PMC 3122263. PMID 21734783.
- ^ a b Yang, Z; Chen, S, Luan, X, Li, Y, Liu, M, Li, X, Liu, T, Tang, H (2009 Nov). "MicroRNA-214 is aberrantly expressed in cervical cancers and inhibits the growth of HeLa cells". IUBMB life 61 (11): 1075–82. doi:10.1002/iub.252. PMID 19859982.
- ^ Zhang, XJ; Ye, H, Zeng, CW, He, B, Zhang, H, Chen, YQ (2010-11-24). "Dysregulation of miR-15a and miR-214 in human pancreatic cancer". Journal of hematology & oncology 3: 46. doi:10.1186/1756-8722-3-46. PMC 3002909. PMID 21106054.
- ^ Zhao, Z.; Tan, X.; Zhao, A.; Zhu, L.; Yin, B.; Yuan, J.; Qiang, B.; Peng, X. (2012). "MicroRNA-214-mediated UBC9 expression in glioma". BMB reports 45 (11): 641–646. PMID 23187003. edit
|
