Stem-loop hsv2-mir-H3

Accession

MI0010692

Description

Herpes Simplex Virus 2 hsv2-mir-H3 precursor miRNA

Gene family

MIPF0000717; mir-H3

Sequence

agcgaggacgcggccggcgcgcucucgaccgcgguucccgagucguacgcagggaccaUUUGGGAGUCUGCGGUUGGGAGcgcgccggggcgcggcacggcu
(((.....((((.((((((((((((((((((((((((((((((.((.(....).)).))))))))).)))))))))))))))))))))..)))).....)))

Structure

   gagga    -g                     -         c  a g 
agc     cgcg  ccggcgcgcucucgaccgcgg uucccgagu gu c c
|||     ||||  ||||||||||||||||||||| ||||||||| || |  
ucg     gcgc  ggccgcgcGAGGGUUGGCGUC GAGGGUUUa ca g a
   gcacg    gg                     U         c  g g 

Annotation confidence Not enough data

Comments

This sequence was named miR-I in [1], but is a clear homolog of miR-H3 in HSV-1.

Genome context

Unknown

Mature hsv2-miR-H3

• Accession: MIMAT0010202
• Description: Herpes Simplex Virus 2 hsv2-miR-H3 mature miRNA
• Sequence: 59 - UUUGGGAGUCUGCGGUUGGGAG - 80
• Evidence: experimental ; 454 [1], Illumina [2-3]

References

1. PubMed ID: 20181707
   Numerous conserved and divergent microRNAs expressed by herpes simplex viruses 1 and 2
   "Jurak I, Kramer MF, Mellor JC, van Lint AL, Roth FP, Knipe DM, Coen DM"
   "J Virol (2010) 84:4659-4672


2. PubMed ID: 19019961
   Novel less-abundant viral microRNAs encoded by herpes simplex virus 2 latency-associated transcript and their roles in regulating ICP34.5 and ICP0 mRNAs
   "Tang S, Patel A, Krause PR"
   "J Virol (2009) 83:1433-1442


3. PubMed ID: 19889786
   Identification of viral microRNAs expressed in human sacral ganglia latently infected with herpes simplex virus 2
   "Umbach JL, Wang K, Tang S, Krause PR, Mont EK, Cohen JI, Cullen BR"
   "J Virol (2010) 84:1189-1192