Stem-loop bta-mir-2484

Accession

MI0011546

Description

Bos taurus bta-mir-2484 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

bta-mir-2484 is a microRNA that has been identified as differentially expressed in the peripheral blood mononuclear cells (PBMCs) of buffaloes infected with Mycobacterium paratuberculosis (M. paratuberculosis) [PMC7242893]. This microRNA was among the top three up-regulated miRNAs in infected buffaloes, with a significant fold-change, indicating its potential role in the host response to infection [PMC5766512]. Additionally, bta-mir-2484 was also differentially expressed in mammary glands infected with Staphylococcus aureus, suggesting a broader role in immune response to bacterial infections [PMC6600136]. The up-regulation of bta-mir-2484 was confirmed in monocyte-derived macrophages (MDMs) infected with M. paratuberculosis as well [PMC6600136]. Interestingly, bta-mir-2484 appears to be nearly species-specific and lacks homology with human or mouse miRNAs, highlighting its potential as a biomarker for bovine-specific infections [PMC6600136]. The expression of bta-mir-2484 has been validated through RT-qPCR following initial RNA-Seq results to ensure the reliability of data regarding its expression levels [PMC6600136]. Furthermore, it is implicated in the regulation of CYP7A1 along with other miRNAs and lncRNAs particularly within the context of dietary influences such as grass feeding [PMC7969984].

Literature search

2 open access papers mention bta-mir-2484
(2 sentences)

Sequence

302 reads, 23 reads per million, 63 experiments

uuaucugaaaauguaugcaggguuauuauaauuaaaaagguGAGCUAUGAUGACUUUGAUUGCAUugaucacauga
((((.(((.((((((..(((((((((((((.(((......)))..)))))))))))))..))))))..))).))))

Structure

    c   -a      ug             -a   aa 
uuau uga  aaugua  caggguuauuaua  uua  a
|||| |||  ||||||  |||||||||||||  |||   
agua acu  uUACGU  GUUUCAGUAGUAU  AGu  a
    c   ag      UA             CG   gg 

Annotation confidence Not enough data

Genome context

chrX: 20570714-20570789 [-]

Mature bta-miR-2484

• Accession: MIMAT0012077
• Description: Bos taurus bta-miR-2484 mature miRNA
• Sequence: 42 - GAGCUAUGAUGACUUUGAUUGCAU - 65
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 19633723
   Repertoire of bovine miRNA and miRNA-like small regulatory RNAs expressed upon viral infection
   Glazov EA, Kongsuwan K, Assavalapsakul W, Horwood PF, Mitter N, Mahony TJ
   PLoS One (2009) 4:e6349