MIR3158-1 is a gene that is found in cases of Split-Hand/Foot Malformation (SHFM) and is duplicated in the majority of SHFM cases [PMC5003447]. In SHFM cases without microarray data, the shortest duplication contains MIR3158-1, along with other genes such as BTRC, POLL, DPCD, MIR3158-2, and a portion of FBXW4 [PMC5003447]. This duplication was found in Patient 35 and 40 [PMC5003447]. In the majority of SHFM cases with microarray data, the duplication also includes LBX1, BTRC, POLL, DPCD, MIR3158-2 and FBXW4 or a portion of FBXW4 [PMC5003447'>PMC5003447'>PMC5003447'>PMC5003447'>PMC5003447'>PMC5003447]. The duplicated segment in these cases extends from centromeric to telomeric direction [PMC5003447]. Patients 30 and 31 have a centromeric duplicated segment containing TLX1NB and TLX1 and a telomeric duplicated segment containing BTRC, POLL, DPCD, MIR3158-1,MIR3158-2,and a portion of FBXW4 (exon 9–7) [PMC5003447]. In some SHFM cases with two discontinuous duplications at 10q24.31–q24.32 (Patient 12–15), one duplication contains LBX1,BTRC,POLL,DPCD,MIR3158-1,MIR3158-2,and a portion of FBXW4 from centromeric to telomeric direction while the other contains LINC01514,LBX1,BTRC,POLL,DPCD,MIR3158-1,MIR3158-2,and a portion of FBXW4 from centromeric to telomeric direction [PMC5003447]. In Patient 18, a 241.59 kb duplication at 10q24.31-q24.32 containing a portion of BTRC, the entire POLL, DPCD, MIR3158-1, MIR3158-2, and a portion of FBXW4 was found [PMC5003447]. This patient exhibited certain phenotypic features associated with SHFM [PMC5003447]. In Patient 1, a 514 kb duplication at 10q24.31-10q24.32 containing LBX1,BTRC,POLL,DPCD,MIR3158-1,MIR3158-2,and FBXW4 was observed [PMC5003447].