Stem-loop sequence hsa-mir-500b

Accession

MI0015903 (change log)

Symbol

HGNC:MIR500B

Description

Homo sapiens miR-500b stem-loop

Gene family

MIPF0000139; mir-500

Literature search

28 open access papers mention hsa-mir-500b
(64 sentences)

Stem-loop

   -      cu -u         uac       ag g   uuu 
5'  cccccu  c  aauccuugc   cugggug  a ugc   c
    ||||||  |  |||||||||   |||||||  | |||   u
3'  ggggga  g  uuaggaacg   gacccac  u acg   g
   a      ac uc         ---       -g g   uaa 

Deep sequencing

15409 reads, 13.2 reads per million, 151 experiments

Confidence

Annotation confidence: not enough data

Feedback: Do you believe this miRNA is real?

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chrX: 50010672-50010750 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000056562 ; CCNB3-005; intron 1

  OTTHUMT00000056558 ; CCNB3-001; intron 1

  OTTHUMT00000056559 ; CCNB3-002; intron 1

  OTTHUMT00000056560 ; CCNB3-003; intron 1

  OTTHUMT00000056561 ; CCNB3-004; intron 2

  ENST00000491907 ; CCNB3-005; intron 1

  ENST00000376042 ; CCNB3-001; intron 1

  ENST00000376038 ; CCNB3-002; intron 1

  ENST00000476167 ; CCNB3-003; intron 1

  ENST00000493507 ; CCNB3-004; intron 2

Clustered miRNAs

< 10kb from hsa-mir-500b

• hsa-mir-532: chrX: 50003148-50003238 [+]
• hsa-mir-188: chrX: 50003503-50003588 [+]
• hsa-mir-500a: chrX: 50008431-50008514 [+]
• hsa-mir-362: chrX: 50008964-50009028 [+]
• hsa-mir-501: chrX: 50009722-50009805 [+]
• hsa-mir-500b: chrX: 50010672-50010750 [+]
• hsa-mir-660: chrX: 50013241-50013337 [+]
• hsa-mir-502: chrX: 50014598-50014683 [+]

Database links

• EntrezGene:MIR500B
• HGNC:MIR500B
• RNAcentral:URS000075AD0A_9606
• miRBase Tracker:MI0015903

Mature sequence hsa-miR-500b-5p

• Accession: MIMAT0016925
• Sequence: 11 - aauccuugcuaccugggu - 28
• Deep sequencing: 14652 reads, 149 experiments
• Evidence: experimental; SOLiD [1], Illumina [2]
• Database links:
  • RNAcentral:URS00000CC005_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-500b-5p
  • miRDB:hsa-miR-500b-5p
  • microrna.org:hsa-miR-500b-5p

Mature sequence hsa-miR-500b-3p

• Accession: MIMAT0027032
• Sequence: 51 - gcacccaggcaaggauucug - 70
• Deep sequencing: 742 reads, 106 experiments
• Evidence: experimental; Illumina [2]
• Database links:
  • RNAcentral:URS000075B475_9606
• Predicted targets:
  • TargetScanVert:hsa-miR-500b-3p
  • miRDB:hsa-miR-500b-3p

References

1. PMID:19784364 "Ago2 immunoprecipitation identifies predicted microRNAs in human embryonic stem cells and neural precursors" Goff LA, Davila J, Swerdel MR, Moore JC, Cohen RI, Wu H, Sun YE, Hart RP PLoS One. 4:e7192(2009).
2. PMID:23034410 "Birth and expression evolution of mammalian microRNA genes" Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H Genome Res. 23:34-45(2013).