Stem-loop hsa-mir-3614

Accession

MI0016004

Symbol

HGNC: MIR3614

Description

Homo sapiens hsa-mir-3614 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR3614 is identified as a microRNA (miRNA) hub within the greenyellow module, suggesting a central role in the network [PMC6399982]. This miRNA is implicated in inflammatory and immune responses related to human intracerebral hemorrhage (ICH) [PMC6399982]. Although MIR3614 is not extensively studied, it is shown to be interconnected with 40 genes, which are significantly enriched in pathways such as IL-6 and IL-10 signaling, granulocyte adhesion and diapedesis, as well as phagosome formation [PMC6399982]. The importance of MIR3614 is further highlighted by its inclusion in a 1.6-Mb microdeletion associated with NOG-SSD (nonsyndromic stapes ankylosis with broad thumb and toes), which affects a total of thirteen genes [PMC4376726].

Literature search

9 open access papers mention hsa-mir-3614
(75 sentences)

Sequence

569 reads, 27 reads per million, 52 experiments

gguucugucuugggCCACUUGGAUCUGAAGGCUGCCCcuuugcucucuggggUAGCCUUCAGAUCUUGGUGUUUUgaauucuuacu
.........(((((.((((.((((((((((((((((((..........)))))))))))))))))).)))).))))).........

Structure

gguucuguc     C    U                  uuug 
         uuggg CACU GGAUCUGAAGGCUGCCCc    c
         ||||| |||| ||||||||||||||||||     
         agUUU GUGG UCUAGACUUCCGAUgggg    u
ucauucuua     U    U                  ucuc 

Annotation confidence Medium

Genome context

chr17: 56891270-56891355 [-]

Mature hsa-miR-3614-5p

• Accession: MIMAT0017992
• Description: Homo sapiens hsa-miR-3614-5p mature miRNA
• Sequence: 15 - CCACUUGGAUCUGAAGGCUGCCC - 37
• Evidence: experimental ; Illumina [1-3]

Mature hsa-miR-3614-3p

• Accession: MIMAT0017993
• Description: Homo sapiens hsa-miR-3614-3p mature miRNA
• Sequence: 53 - UAGCCUUCAGAUCUUGGUGUUUU - 75
• Evidence: experimental ; Illumina [1-3]

References

1. PubMed ID: 20459774
   Ultra-high throughput sequencing-based small RNA discovery and discrete statistical biomarker analysis in a collection of cervical tumours and matched controls
   Witten D, Tibshirani R, Gu SG, Fire A, Lui WO
   BMC Biol (2010) 8:58


2. PubMed ID: 21199797
   Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene
   "Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C"
   "Cancer Res (2011) 71:78-86


3. PubMed ID: 21807764
   Deep sequencing of small RNAs from human skin reveals major alterations in the psoriasis miRNAome
   "Joyce CE, Zhou X, Xia J, Ryan C, Thrash B, Menter A, Zhang W, Bowcock AM"
   "Hum Mol Genet (2011) 20:4025-4040