Stem-loop hsa-mir-4446

Accession

MI0016789

Symbol

HGNC: MIR4446

Description

Homo sapiens hsa-mir-4446 precursor miRNA mir-4446

Gene
family

RF03251; mir-4446

Literature search

2 open access papers mention hsa-mir-4446
(7 sentences)

Sequence

1028 reads, 6 reads per million, 40 experiments

cugguccAUUUCCCUGCCAUUCCCUUGGCuucaauuuacuccCAGGGCUGGCAGUGACAUGGGUcaa
.((((((((.((.((((((...((((((.............)))))).)))))).)).)))))))).

Structure

c        U  C      UUC      Cuuca 
 ugguccAU UC CUGCCA   CCUUGG     a
 |||||||| || ||||||   ||||||     u
 acUGGGUA AG GACGGU   GGGACc     u
a        C  U      --C      cucau 

Annotation confidence Low

Genome context

chr3: 113594876-113594942 [+]

Disease association

hsa-mir-4446 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-4446-5p

• Accession: MIMAT0019233
• Description: Homo sapiens hsa-miR-4446-5p mature miRNA
• Sequence: 8 - AUUUCCCUGCCAUUCCCUUGGC - 29
• Evidence: experimental ; Illumina [2-3]

Mature hsa-miR-4446-3p

• Accession: MIMAT0018965
• Description: Homo sapiens hsa-miR-4446-3p mature miRNA
• Sequence: 43 - CAGGGCUGGCAGUGACAUGGGU - 64
• Evidence: experimental ; Illumina [1-3]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127


2. PubMed ID: 21199797
   Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene
   "Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C"
   "Cancer Res (2011) 71:78-86


3. PubMed ID: 22454130
   Transcription factors are targeted by differentially expressed miRNAs in primates
   "Dannemann M, Prufer K, Lizano E, Nickel B, Burbano HA, Kelso J"
   "Genome Biol Evol (2012) 4:552-564