Stem-loop sequence hsa-mir-4446

Accession

MI0016789 (change log)

Symbol

HGNC:MIR4446

Description

Homo sapiens miR-4446 stem-loop

Gene family

MIPF0001385; mir-4446

Literature search

2 open access papers mention hsa-mir-4446
(7 sentences)

Stem-loop

   c  gu    u  c      uuc      cuuca 
5'  ug  ccau uc cugcca   ccuugg     a
    ||  |||| || ||||||   ||||||     u
3'  ac  ggua ag gacggu   gggacc     u
   a  ug    c  u      --c      cucau 

Deep sequencing

1750 reads, 1.35 reads per million, 74 experiments

Confidence

Annotation confidence: not enough data

Feedback: Do you believe this miRNA is real?

Genome context

• Coordinates (GRCh38; GCA_000001405.15): chr3: 113594876-113594942 [+]
• Overlapping transcripts:

  sense

  OTTHUMT00000354747 ; GRAMD1C-015; intron 2

  OTTHUMT00000354748 ; GRAMD1C-016; intron 3

  OTTHUMT00000354736 ; GRAMD1C-004; intron 4

  OTTHUMT00000354733 ; GRAMD1C-001; intron 4

  OTTHUMT00000354742 ; GRAMD1C-010; intron 4

  OTTHUMT00000354735 ; GRAMD1C-003; intron 4

  ENST00000463760 ; GRAMD1C-015; intron 2

  ENST00000484714 ; GRAMD1C-016; intron 3

  ENST00000452134 ; GRAMD1C-201; intron 3

  ENST00000479212 ; GRAMD1C-004; intron 4

  ENST00000358160 ; GRAMD1C-001; intron 4

  ENST00000486457 ; GRAMD1C-010; intron 4

  ENST00000472384 ; GRAMD1C-003; intron 4

Database links

• EntrezGene:MIR4446
• HGNC:MIR4446
• RNAcentral:URS000075A805_9606
• miRBase Tracker:MI0016789

Mature sequence hsa-miR-4446-5p

• Accession: MIMAT0019233
• Sequence: 8 - auuucccugccauucccuuggc - 29
• Deep sequencing: 22 reads, 17 experiments
• Evidence: experimental; Illumina [2-3]
• Predicted targets:
  • TargetMiner:hsa-miR-4446-5p
  • TargetScanVert:hsa-miR-4446-5p
  • miRDB:hsa-miR-4446-5p

Mature sequence hsa-miR-4446-3p

• Accession: MIMAT0018965
• Sequence: 43 - cagggcuggcagugacaugggu - 64
• Deep sequencing: 1728 reads, 67 experiments
• Evidence: experimental; Illumina [1-3]
• Database links:
  • RNAcentral:URS000000EF0B_9606
• Predicted targets:
  • TargetMiner:hsa-miR-4446-3p
  • TargetScanVert:hsa-miR-4446-3p
  • miRDB:hsa-miR-4446-3p

References

1. PMID:20733160 "Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs" Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI, Blood. 116:e118-e127(2010).
2. PMID:21199797 "Identification of new microRNAs in paired normal and tumor breast tissue suggests a dual role for the ERBB2/Her2 gene" Persson H, Kvist A, Rego N, Staaf J, Vallon-Christersson J, Luts L, Loman N, Jonsson G, Naya H, Hoglund M, Borg A, Rovira C Cancer Res. 71:78-86(2011).
3. PMID:22454130 "Transcription factors are targeted by differentially expressed miRNAs in primates" Dannemann M, Prufer K, Lizano E, Nickel B, Burbano HA, Kelso J Genome Biol Evol. 4:552-564(2012).