Stem-loop hsa-mir-4492

Accession

MI0016854

Symbol

HGNC: MIR4492

Description

Homo sapiens hsa-mir-4492 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR4492 is a microRNA gene that was investigated using RT-qPCR with TaqMan microRNA assays [PMC7000740]. However, the effects of MIR4492 could not be characterized using summary statistics alone [PMC10061723]. A risk single nucleotide polymorphism (SNP) was identified in an enhancer-like domain near MIR4492, suggesting that the regulation of this microRNA gene is influenced by other factors [PMC10061723]. Further investigation is needed to understand the impact of this enhancer SNP on MIR4492 expression in multiple sclerosis (MS) patients, particularly in the context of Epstein-Barr virus (EBV) infection [PMC10061723]. Other miRNA genes located on 11q include miR5579, miR3166, miR1261, miR4300, miR4490, miR1304, miR1260B, miR3920, miR4693, miR4491, and MIR4493. However, their functions remain unknown [PMC5492892]. One of these genes is located near MIR4492 on 11q23 and its function is also unknown [PMC5492892].

Literature search

7 open access papers mention hsa-mir-4492
(20 sentences)

Sequence

271 reads, 31 reads per million, 41 experiments

cugcagcgugcuucuccaggccccgcgcgcggacagacacacggacaagucccgccaGGGGCUGGGCGCGCGCCagccgg
..((.((((((...(((((.((((..(((.((((..............)))))))..))))))))).))))))..))...

Structure

-cu  -a      uuc     g    gc   c    agacac 
   gc  gcgugc   uccag cccc  gcg ggac      a
   ||  ||||||   ||||| ||||  ||| ||||       
   cg  CGCGCG   GGGUC GGGG  cgc ccug      c
ggc  aC      --C     -    ac   -    aacagg 

Annotation confidence Not enough data

Genome context

chr11: 118910708-118910787 [+]

Disease association

hsa-mir-4492 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-4492

• Accession: MIMAT0019027
• Description: Homo sapiens hsa-miR-4492 mature miRNA
• Sequence: 58 - GGGGCUGGGCGCGCGCC - 74
• Evidence: experimental ; Illumina [1]

References

1. PubMed ID: 20733160
   Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs
   "Jima DD, Zhang J, Jacobs C, Richards KL, Dunphy CH, Choi WW, Au WY, Srivastava G, Czader MB, Rizzieri DA, Lagoo AS, Lugar PL, Mann KP, Flowers CR, Bernal-Mizrachi L, Naresh KN, Evens AM, Gordon LI, Luftig M, Friedman DR, Weinberg JB, Thompson MA, Gill JI,"
   "Blood (2010) 116:e118-e127