Accession
MI0016868
Symbol
HGNC:
MIR4505
Description
Homo sapiens
hsa-mir-4505 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
Hsa-mir-4505 is a microRNA that has been studied in various contexts, including infectious diseases, cardiovascular events, and cancer. It has been shown to be involved in the regulation of target genes such as C8orf37, EFNA5, HOOK3, MYOZ3, PCP4L1, SLC2A3, SNRPA1, IQCG, PLAG1, and POLI [PMC9738797]. In the context of infectious diseases and HIV infection specifically, hsa-mir-4505 has been found to be downregulated in different comparisons such as VP vs HIV-, EC vs HIV-, and ART vs HIV- [PMC4865051]. In cardiovascular events patients and non-small cell lung cancer (NSCLC), hsa-mir-4505 was found to be downregulated [PMC9827273] [PMC6830863]. However, the role of hsa-mir-4505 in cardiovascular risk or disease is not yet known [PMC9827273]. In NSCLC specifically hsa-mir-4505 was found to be regulated by lncRNA DGCR5 [PMC6830863]. Hsa-mir-4505 has also been shown to target S100A12 and regulate heat shock protein A12B (HSPA12B) in vascular endothelial cell injury induced by lipopolysaccharide (LPS) [PMC9436632]. Furthermore a miRNA-mRNA regulatory network was constructed that included hsa-mir-4505 targeting RBM28 mRNA among others [PMC9532133]. However the expression levels of hsa-mir-4505 were not proven to be significant in some studies [PMC4416288]
Literature search
2 open access papers mention hsa-mir-4505
(3 sentences)
(3 sentences)
Sequence
19
reads,
4
reads per million, 8 experiments
ggAGGCUGGGCUGGGACGGAcacccggccuccacuuucuguggcagguaccuccuccaugucggcccgccuug
.(((((.(((((((.(.(((......((((((((.....)))).))))......))).).)))))))))))).
.(((((.(((((((.(.(((......((((((((.....)))).))))......))).).)))))))))))).
Structure
g U G C cacccg - u gAGGC GGGCUGG A GGA gccu ccac u ||||| ||||||| | ||| |||| |||| u uuccg cccggcu u ccu ugga ggug c g - g a ccucca c u
Annotation confidence
Not enough data
Do you think this miRNA is real?
Genome context
chr14: 73758747-73758819 [+]
Disease association
hsa-mir-4505 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-4505
| Accession | MIMAT0019041 |
| Description | Homo sapiens hsa-miR-4505 mature miRNA |
| Sequence | 3 - AGGCUGGGCUGGGACGGA - 20 |
| Evidence |
experimental
Illumina [1] |
| Database links |
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| Predicted targets |
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References
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