Dead hairpin entry

Stem-loop hsa-mir-1244-4

Accession

MI0031511

Symbol

HGNC: MIR1244-4

Description

Homo sapiens hsa-mir-1244-4 precursor miRNA mir-1244

Gene
family

RF04271; mir-1244

Comment

The read data does not support this entry being a bona fide miRNA.

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

WARNING: This summary was generated by AI. MIR1244-1 is a microRNA (miRNA) that is less than 22 nucleotides in length and has been identified as a downregulated tumor suppressor in a cluster that includes six other tumor suppressors [PMC8465636]. This miRNA has been consistently observed across different tissue types, indicating its disease-specific differential expression [PMC8323253]. Furthermore, MIR1244-1 is among the miRNAs that undergo hypermethylation due to tobacco exposure in the foetal cord blood of low-birth-weight newborns of smoking mothers, which may influence foetoplacental angiogenic and growth factors [PMC9571148]. The hypermethylation of MIR1244-1 and other miRNAs has been associated with the disruption of protein expression and key factors necessary for proper placental development [PMC9571148]. Additionally, MIR1244-1 was one of seven hypermethylated miRNAs identified in a genetic study focusing on cord blood from low-birth-weight newborns with smoking mothers [PMC9571148]. In terms of its prognostic value, MIR1244-1 has been recognized as an independent prognostic factor for certain diseases through multivariate Cox regression analysis [PMC9691390].

Literature search

8 open access papers mention hsa-mir-1244-4
(17 sentences)

Sequence

16823 reads, 1503.0 reads per million, 60 experiments

aucuuAUUCCGAGCAUUCCAGUAACUuuuuuguguauguacuuagcuguacuauAAGUAGUUGGUUUGUAUGAGAUGGUUaaaaa
(((((((.....(((..((((..(((......((((.((((......)))))))))))..))))..)))))))))).........

Structure

---------       UCCGA   UU    UA   uuuuug    u    uu 
         aucuuAU     GCA  CCAG  ACU      ugua guac  a
         |||||||     |||  ||||  |||      |||| ||||   
         UAGAGUA     UGU  GGUU  UGA      Auau caug  g
aaaaaUUGG       -----   UU    GA   ------    -    uc