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14 publications mentioning rno-mir-330

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-330. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 31
Specifically, miR-195 potentially regulates vesicle -associated membrane protein 1 (VAMP1), miR-30a targets actinin, alpha 1 (ACTN1), miR-21 targets paired-like homeodomain 2 (PITX2) in D6; miR-132 potentially regulates solute carrier family 2, member 1 (SLC2A1), nuclear receptor subfamily 4, group A, member 2 (NR4A2) and Cdc42 guanine nucleotide exchange factor 9 (ARHGEF9), miR-203 targets calcium binding protein 7 (CABP7), miR-17-5p targets early growth response 2 (EGR2) in S6; miR-330 potentially regulates CD247, nerve growth factor receptor (NGFR) and FAT tumor suppressor homolog 3 (FAT3), miR-338 targets ADAM metallopeptidase domain 17 (ADAM17), miR-218 targets src kinase associated phosphoprotein 1 (SKAP1), miR-185 targets calcium channel, voltage -dependent, N type, alpha 1B subunit (CACNA1B) in S9. [score:20]
MiR-330 is reported to induce apoptosis in prostate cancer cells through E2F1 -mediated suppression of Akt phosphorylation [44], and in our subnetwork NGFR (also known as P [75]NTR) is the target of miR-330. [score:5]
In the cell adhesion subnetwork, CD247, the target of miR-330, plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways [46]. [score:3]
Consequently, SCs may alter miRNA expression, including miR-330, miR-218 (in S9) and miR-132 (in S6), to modulate two-way communication between neurons and SCs to maintain structural integrity and functional recovery after axotomy to the peripheral nerves. [score:3]
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[+] score: 20
These selected miRNAs included the seven most strongly upregulated miRNAs (miR-330, miR-338, miR-223, miR-20a, miR-181a, miR-592, miR-212) in the Ago2 IP at 30 min, the only downregulated miRNA (miR-29b) in the Ago2 IP at 30 min, and the three most strongly upregulated miRNAs (miR-219, miR-384, let-7f) in the Ago2 IP at 120 min post-HFS (significant by t-test with Dunn–Bonferroni correction and 1-Way ANOVA with LSD test). [score:10]
Target gene list sizes for miRNAs with activity -dependent association with Ago2 for the 8 enhanced miRNAs were 97 (miR-20a), 156 (miR-219), 58 (miR-223), 114 (miR-29b), 30 (miR-330), 91 (miR-34a), 156 (miR-384), and 53 (miR-592) and for the 5 depleted miRNAs were 52 (let-7f), 55 (miR-338), 47 (miR-212), 255 (miR-19a), 32 (miR-326). [score:3]
miR-330 and miR-223 expression was unchanged or slightly decreased in input samples at 30 min post-HFS but enhanced in the Ago2 IP. [score:3]
When comparing miRNA Ago2/input expression ratios, eight miRNAs (miR-384, miR-29b, miR-219, miR-592, miR-20a, miR-330 miR-223, and miR-34a) exhibited increases relative to the contralateral dentate gyrus, whereas five miRNAs (miR-let7f, miR-338, miR-212, miR-19a, and miR-326) showed decreases in this ratio. [score:3]
Seven miRNAs (miR-384, miR-29b, miR-219, miR-592, miR-20a, miR-330, and miR-223) showed enhanced, NMDAR -dependent association with Ago2. [score:1]
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[+] score: 15
RT-PCR validation of these 9 miRNAs confirmed the high expression of 7 miRNAs, of which 3 (miR-503, miR-330 and miR-293) were exclusively expressed in dnIKK2-Treg-EV, while the remaining 4 miRNAs (miR-297c, miR-207, miR-9, miR-484) were faintly detected in Tact-EV and Trest-EV too (Fig.   5A). [score:5]
Target prediction of cell cycle genes targeted by miR-503, miR-330 and miR-9 included CCNE1, CCNE2, CCND1, CDC14A, E2F1-3, CDKN1A, CDC25A, CHEK1, WEE1 and EP300 (Supplementary Fig.   8) 25, 26. [score:5]
Namely, miR-503, miR-330 and miR-9, which affect the transcription of genes encoding proteins crucial to the regulation of cell cycle progression, were exclusively present or were up-regulated in dnIKK2-Treg-EV compared to Tact-EV and Trest-EV. [score:4]
This analysis highlighted 3 miRNAs (miR-503, miR-330 and miR-9) potentially affecting 16 pathways (Supplementary Table  3) among which cell cycle was the most closely related to anti-proliferative effects of dnIKK2-Treg-EV. [score:1]
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[+] score: 14
Other miRNAs from this paper: rno-mir-326, rno-mir-485, rno-mir-761, rno-mir-666
Many of the miRNAs that were identified are encoded within the introns of host genes that are expressed in hippocampus: miR-326 (Arrb1, β-arrestin), miR-330 (Eml2, echinoderm microtubule associate protein like 2) and miR-761 (Nrd1, Nardilysin) (electronic supplementary material, figure S3). [score:3]
Expression levels for miR-330-5p only modestly increased by 21 days post parturition (miR-456 expression, corresponding to motif 3 and sharing a seed motif with miR-485-5p was very low at all time points measured). [score:3]
Ingenuity pathway analysis was performed on predicted targets of miR-326-3p/miR-330-5p, miR-485-5p, miR-666-3p and miR-761 using the T argetS can v. 6.2 algorithm [49– 51]. [score:3]
Several of the corresponding miRNAs, including miR-326/miR-330, miR-485, miR-666 and miR-761 were found to be developmentally regulated in the hippocampus. [score:3]
11 × 10 [−7] – 1.36 × 10 [−2] axon guidance signalling6.93 × 10 [−4] RAN signalling7.63 × 10 [−4] netrin signalling2.97 × 10 [−3] miR-326/miR-330 top canonical pathways. [score:1]
We found that four of the discovered motifs (figure 3 a) in the destabilized gene set corresponded to seed domains of miRNAs miR-326-3p/miR-330-5p, miR-485-5p, miR-666-3p and miR-761. [score:1]
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[+] score: 13
As shown in Figure 5b, VEGFA were targeted by the greatest number of the differential miRNAs, among which miR-429, miR-200b and miR-200c also interacted with VEGFC; in contrast, VEGFB was targeted only by miR-18a, miR-326, miR-330 and miR-128. [score:5]
In contrast, rno-miR-330-5p, rno-miR-223-5p and rno-miR-191a-3p exhibited the greatest down-regulations, which were approximately four-fold changes. [score:4]
To confirm the deep sequencing results, we used qRT-PCR to assess the expressions of 10 of the miRNAs (miR-183-5p, miR-9a-5p, miR-199a-5p, miR-351-5p, miR200b-3p, miR-191a-3p, miR-181c-3p, miR-330-5p, miR-126a-5p and miR-351-3p) in the 12-pair plasma samples from the hyperoxia rats and controls. [score:3]
Comparisons of the high-throughput sequencing and qRT-PCR results indicated that the two plarforms exhibited good correlation; and (b) The 5p/3p ratio validation results for miR-126a, miR-330 and miR-351 by qPCR also indicated good correlation between the two platforms. [score:1]
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[+] score: 7
In particular, downregulation of miR-874 (−2.89-fold change, p = 0.002), mir-20b (−3.37-fold change, p = 0.005), miR-330 (−4.11-fold change, p = 0.006), and miR-326 (−2.22-fold change, p = 0.008), and upregulation of miR-3545-5p (1.97-fold change, p = 0.006), miR-3548 (2.59-fold change, p = 0.006), and miR-21 (3.52-fold change, p = 0.017) was observed. [score:7]
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[+] score: 6
Interestingly, the genes predicted to be targeted by MIR330-3p appear to primarily fall into the functional categories of transcription regulation and ubiquitination (Table S9). [score:4]
We found evidence for enrichment of the MIR330-3p seed sequence within our 5 h data set (p = 7.3e-04). [score:1]
Table S9 Genes with sequence motifs from 5 h LRG list corresponding to rno-MIR330-3p. [score:1]
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[+] score: 5
Four miRNAs were upregulated after exercise: rno-miR-330-5p (FDR = 0.0284), 10b-5p (FDR = 0.0381), 142-3p (FDR = 0.0454) and 410-3p (FDR = 0.0461). [score:4]
After exercise, four rat serum EVs miRNAs were found increased: rno-miR-330-5p, 10b-5p, 142-3p, and 4100-3p. [score:1]
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[+] score: 5
Among up-regulated miRNAs, miR-330 regulates CD44 and CDC42 and thus modulates tumourigenesis and angiogenesis in cancer [21]. [score:5]
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[+] score: 4
In the Partially Normalized subgrouping, a set of genes with the predicted mir-330 binding target (TGCTTTG) was over-represented, all of which were suppressed in diabetic and insulin -treated diabetic compared to non-diabetic controls. [score:4]
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[+] score: 3
The number of target genes predicted for each microRNA varied from 2 (miR-330) to 436 (let-7c) (Figure S2). [score:3]
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[+] score: 3
Other miRNAs from this paper: mmu-mir-30a, mmu-mir-101a, mmu-mir-125a, mmu-mir-125b-2, mmu-mir-132, mmu-mir-134, mmu-mir-135a-1, mmu-mir-138-2, mmu-mir-142a, mmu-mir-150, mmu-mir-154, mmu-mir-182, mmu-mir-183, mmu-mir-24-1, mmu-mir-194-1, mmu-mir-200b, mmu-mir-122, mmu-mir-296, mmu-mir-21a, mmu-mir-27a, mmu-mir-92a-2, mmu-mir-96, rno-mir-322-1, mmu-mir-322, mmu-mir-330, rno-mir-339, mmu-mir-339, rno-mir-342, mmu-mir-342, rno-mir-135b, mmu-mir-135b, mmu-mir-19a, mmu-mir-100, mmu-mir-139, mmu-mir-212, mmu-mir-181a-1, mmu-mir-214, mmu-mir-224, mmu-mir-135a-2, mmu-mir-92a-1, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-125b-1, mmu-mir-194-2, mmu-mir-377, mmu-mir-383, mmu-mir-181b-2, rno-mir-19a, rno-mir-21, rno-mir-24-1, rno-mir-27a, rno-mir-30a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-96, rno-mir-100, rno-mir-101a, rno-mir-122, rno-mir-125a, rno-mir-125b-1, rno-mir-125b-2, rno-mir-132, rno-mir-134, rno-mir-135a, rno-mir-138-2, rno-mir-138-1, rno-mir-139, rno-mir-142, rno-mir-150, rno-mir-154, rno-mir-181b-1, rno-mir-181b-2, rno-mir-183, rno-mir-194-1, rno-mir-194-2, rno-mir-200b, rno-mir-212, rno-mir-181a-1, rno-mir-214, rno-mir-296, mmu-mir-376b, mmu-mir-370, mmu-mir-433, rno-mir-433, mmu-mir-466a, rno-mir-383, rno-mir-224, mmu-mir-483, rno-mir-483, rno-mir-370, rno-mir-377, mmu-mir-542, rno-mir-542-1, mmu-mir-494, mmu-mir-20b, mmu-mir-503, rno-mir-494, rno-mir-376b, rno-mir-20b, rno-mir-503-1, mmu-mir-1224, mmu-mir-551b, mmu-mir-672, mmu-mir-455, mmu-mir-490, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-504, mmu-mir-466d, mmu-mir-872, mmu-mir-877, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-872, rno-mir-877, rno-mir-182, rno-mir-455, rno-mir-672, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-466j, rno-mir-551b, rno-mir-490, rno-mir-1224, rno-mir-504, mmu-mir-466m, mmu-mir-466o, mmu-mir-466c-2, mmu-mir-466b-4, mmu-mir-466b-5, mmu-mir-466b-6, mmu-mir-466b-7, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, rno-mir-466d, mmu-mir-466q, mmu-mir-21b, mmu-mir-21c, mmu-mir-142b, mmu-mir-466c-3, rno-mir-322-2, rno-mir-503-2, rno-mir-466b-3, rno-mir-466b-4, rno-mir-542-2, rno-mir-542-3
StAR may be a target gene of miR-376b, miR-150, miR-330 and miR-138. [score:3]
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[+] score: 3
Other miRNAs from this paper: rno-mir-343, rno-mir-122
Two microRNAs, miR-330 and miR-343, were found in the candidate region by screening miRNA databases (miRBase and Rat Genome Database), but the expression of these microRNAs was not detected in the kidneys of SHRSP and SHR (data not shown, see). [score:3]
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[+] score: 1
Interestingly, in network 2, we detected signaling components involved in extracellular matrix organization, such as PLAU (miR-331) and CHSY1 (miR-1*, miR-330). [score:1]
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