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23 publications mentioning mmu-mir-339

Open access articles that are associated with the species Mus musculus and mention the gene name mir-339. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

[+] score: 87
Other miRNAs from this paper: hsa-mir-339
Moreover, our previous study revealed that expression of BCL6 was regulated by miR-339-5p [18], but it was unclear whether BCL6 is a direct target gene of miR-339-5p. [score:7]
In conclusion, our current study demonstrated that the reduced miR-339-5p expression [our previous data (ref)] promoted BCL6 expression, which in turn induces cyclinD1 and CXCR4 expression for induction of breast cancer cell proliferation and invasion. [score:7]
Our previous study revealed that expression of BCL6 was down-regulated by miR-339-5p [18]. [score:6]
Forced expression of miR-339-5p reduced the activity of a luciferase reporter gene fused to the full length wild-type BCL6 3’UTR, indicating that miR-339-5p directly targets BCL6 (Figures  6b and c). [score:6]
Expression of miR-339-5p resulted in substantial reduced levels of BCL6 mRNA and protein in T47D cells, while depletion of miR-339-5p expression using miR-339-5p ASO significantly increase in levels of BCL6 mRNA and protein (Figure  6a). [score:5]
To verify BCL6 as the bona fide target of miR-339-5p, qRT-PCR and western blot analyses were performed to detect the expression levels of BCL6 in breast caner cells transfected with either miR-339-5p mimics or miR-339-5p ASO. [score:5]
A previous study has reported that expression of miR-339-5p inhibited breast cancer cell migration and invasion [18]. [score:5]
At the gene level, BCL6 induced CXCR4 and cyclinD1 expression and BCL6 is the target gene of miRNA, miR-339-5p. [score:5]
We first depleted BCL6 expression by siRNA and co -transfected the cells with miR-339-5p ASO and observed that depletion of BCL6 expression significantly abrogated miR-339-5p ASO -induced tumor cell migration and invasion, indicating that BCL6 plays a critical role at the downstream of miR-339-5p (Figure  6d). [score:5]
The bioinformatic analysis and luciferase assay showed that BCL6 expression could be directly targeted by miR-339-5p. [score:5]
BCL6 is a direct target of miR-339-5p. [score:4]
Bioinformatic analysis utilized the algorithm of Targetscan [24] showed that BCL6 mRNA contains a 3’-UTR element complementary to the miR-339-5p binding site. [score:3]
Although miR-339-5p may target different genes, BCL6 is definitely one of them. [score:3]
Our current data on manipulating miR-339-5p expression did alter effects of BCL6 on breast cancer cells. [score:3]
miR-339-5p mimics or miR-339-5p ASO was transiently transfected into T47D cells and subjected to analysis of BCL6 expression. [score:3]
qRT-PCR was then performed to detect expression of BCL6, GAPDH, miR-339-5p, U6, and common tumor-related genes as described previously [15, 17, 18]. [score:3]
At the gene level, BCL6 was a target gene of miR-339-5p. [score:3]
Our luciferase assay indeed confirmed that BCL6 is the target gene of miR-339-5p. [score:2]
miR-339-5p has been implicated in regulation of cell proliferation, migration and invasion in different cancers [18, 35]. [score:2]
A psiCHECK-2 construct containing 3’UTR of BCL6 with a mutated sequence of miR-339-5p was also generated. [score:1]
Briefly, cells (1.0 ×10 [5] /well) were seeded in 6-well plates and transiently transfected with BCL6 small interfering RNA (siRNA) or control scrambled siRNA duplex (GenePharma, Shanghai, China) or with 2’-O methylated single-stranded miR-339-5p antisense oligonucleotides (ASO) vs. [score:1]
After that, psiCHECK-2-BCL6 3’UTR and psiCHECK-2-mut-BCL6 3’UTR were co -transfected with 20 pmol miRNA-339-5p mimics or its negative control into breast cancer cells using Lipofectamine 2000 as described previously [15, 17]. [score:1]
its negative control or miR-339-5p mimics (all from GenePharma) vs. [score:1]
We therefore proceeded to determine whether BCL6 was involved in miR-339-5p -mediated cell migration and invasion. [score:1]
[1 to 20 of 24 sentences]
[+] score: 38
The TaqMan® Array Human MicroRNA Card contained all 13 possible miRs predicted to target IRAK-1, and 24 h HG-stimulation caused the downregulation of seven endothelial miRs: miR-146a-5p, miR-339-5p, miR-874-3p, miR-125-3p, miR-431-5p, miR-192-5p, and miR-215-5p (Figure 2A). [score:6]
Real-time PCR analyses of 24 h HG-stimulated HAECs showed that only miR-146a-5p, miR-339-5p, miR-874-3p, and miR-125-3p expression were significantly downregulated compared to the unstimulated control (Figure 2B). [score:5]
When HAECs were stimulated with HG for 48 h, the expression levels of miR-146a-5p, miR-339-5p, and miR-874-3p were significantly downregulated compared to the unstimulated control (Figure 2C). [score:5]
The miR target analysis showed homologies between the 3′-UTR of the human IRAK-1 mRNA and miR-146a-5p (two binding sites), miR-339-5p, and miR-874-3p, indicating potential regulation of IRAK-1 (Figure 3A). [score:4]
Figure 2 (A–C) MiR-146a-5p, miR-339-5p, and miR-874-3p were downregulated in 24 and 48 h HG -treated HAECs. [score:4]
MiR-146a-5p, miR-339-5p, and miR-874-3p were downregulated in HG -treated HAECs. [score:4]
HG stimulation for 24 h revealed that seven miRs, miR-146a-5p, miR-339-5p, miR-874-3p, miR-125-3p, miR-431-5p, miR-192-5p, and miR-215-5p, were downregulated by HG, as compared with unstimulated control. [score:3]
In our study, although miR-339-5p and miR-874-3p had mirSVR scores that ranked them fourth and fifth among our 13 miRanda-predicted miRs that would interact with the 3′-UTR of IRAK-1 mRNA, in the transfection assays, these miRs did not regulate IRAK-1 expression. [score:3]
HG stimulation for 24 h decreased miR-146a-5p, miR-339-5p, miR-874-3p, and miR-125-3p expression levels to 18, 20, 28, and 54% of the control level, respectively. [score:3]
HG stimulation for 48 h decreased miR-146a-5p, miR-339-5p, and miR-874-3p to 68, 60, and 49% of the control level, respectively. [score:1]
[1 to 20 of 10 sentences]
[+] score: 36
In the current study, we demonstrated folic acid supplementation could up-regulate miR-339-5p and down-regulate BACE1 expression, which can further confirm the relationship between folic acid, miR-339-5p and BACE1. [score:9]
Long J. M. Ray B. Lahiri D. K. MicroRNA-339-5p down-regulates protein expression of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) in human primary brain cultures and is reduced in brain tissue specimens of Alzheimer disease subjects J. Biol. [score:7]
On the contrary, miR-339-5p was down-regulated in the deficiency group and was up-regulated in both 120 μg/kg and 600 μg/kg groups compared to the control group (F[3,20] = 138.1, p < 0.05; Figure 5B). [score:6]
In a previous study we have revealed folic acid deficiency down-regulated miR-339-5p, which targets BACE1 [19]. [score:6]
miR-339-5p possibly target the seed same region on 3′-UTR of BACE1. [score:3]
BACE1 is the target of miR-186 and miR-339 [13, 14]. [score:3]
However, miR-339-5p expression showed a reverse trend compared to miR-126-3p. [score:2]
[1 to 20 of 7 sentences]
[+] score: 15
miR-25, miR-32, miR-661 and miR-339–5p target MDM2 to up-regulate p53 protein levels and function [27– 30]. [score:6]
Recently, several miRNAs, including miR-143/145, miR-192/194, miR-339–5p and miR-509-5p have been identified to regulate p53 levels and function through directly targeting MDM2 [27, 29, 30, 48, 49]. [score:5]
miR-339–5p is frequently down-regulated in colorectal cancer and breast cancer [29, 30]. [score:4]
[1 to 20 of 3 sentences]
[+] score: 15
The resulting networks involve 48 (CTX) and 60 (MB) molecular nodes, featuring several diverse regulatory mechanisms: coexpressed miRNAs targeting the same regulated gene (e. g., miR-532-3p and miR-339-5p on Pea15 in the MB), genes encoding physically interacting or coexpressed proteins targeted by the same miRNA (e. g., miR-494-3p on both Dpysl2 and Dpysl3, and miR-140-3p on coexpressed Flot1 and Dnm1 in the CTX), and isoform-specific translational repression (e. g., Hnrnpa2b1 in the MB). [score:15]
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[+] score: 8
Other miRNAs from this paper: mmu-mir-30a, mmu-mir-101a, mmu-mir-125a, mmu-mir-125b-2, mmu-mir-132, mmu-mir-134, mmu-mir-135a-1, mmu-mir-138-2, mmu-mir-142a, mmu-mir-150, mmu-mir-154, mmu-mir-182, mmu-mir-183, mmu-mir-24-1, mmu-mir-194-1, mmu-mir-200b, mmu-mir-122, mmu-mir-296, mmu-mir-21a, mmu-mir-27a, mmu-mir-92a-2, mmu-mir-96, rno-mir-322-1, mmu-mir-322, rno-mir-330, mmu-mir-330, rno-mir-339, rno-mir-342, mmu-mir-342, rno-mir-135b, mmu-mir-135b, mmu-mir-19a, mmu-mir-100, mmu-mir-139, mmu-mir-212, mmu-mir-181a-1, mmu-mir-214, mmu-mir-224, mmu-mir-135a-2, mmu-mir-92a-1, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-125b-1, mmu-mir-194-2, mmu-mir-377, mmu-mir-383, mmu-mir-181b-2, rno-mir-19a, rno-mir-21, rno-mir-24-1, rno-mir-27a, rno-mir-30a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-96, rno-mir-100, rno-mir-101a, rno-mir-122, rno-mir-125a, rno-mir-125b-1, rno-mir-125b-2, rno-mir-132, rno-mir-134, rno-mir-135a, rno-mir-138-2, rno-mir-138-1, rno-mir-139, rno-mir-142, rno-mir-150, rno-mir-154, rno-mir-181b-1, rno-mir-181b-2, rno-mir-183, rno-mir-194-1, rno-mir-194-2, rno-mir-200b, rno-mir-212, rno-mir-181a-1, rno-mir-214, rno-mir-296, mmu-mir-376b, mmu-mir-370, mmu-mir-433, rno-mir-433, mmu-mir-466a, rno-mir-383, rno-mir-224, mmu-mir-483, rno-mir-483, rno-mir-370, rno-mir-377, mmu-mir-542, rno-mir-542-1, mmu-mir-494, mmu-mir-20b, mmu-mir-503, rno-mir-494, rno-mir-376b, rno-mir-20b, rno-mir-503-1, mmu-mir-1224, mmu-mir-551b, mmu-mir-672, mmu-mir-455, mmu-mir-490, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, mmu-mir-466c-1, mmu-mir-466e, mmu-mir-466f-1, mmu-mir-466f-2, mmu-mir-466f-3, mmu-mir-466g, mmu-mir-466h, mmu-mir-504, mmu-mir-466d, mmu-mir-872, mmu-mir-877, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-872, rno-mir-877, rno-mir-182, rno-mir-455, rno-mir-672, mmu-mir-466l, mmu-mir-466i, mmu-mir-466f-4, mmu-mir-466k, mmu-mir-466j, rno-mir-551b, rno-mir-490, rno-mir-1224, rno-mir-504, mmu-mir-466m, mmu-mir-466o, mmu-mir-466c-2, mmu-mir-466b-4, mmu-mir-466b-5, mmu-mir-466b-6, mmu-mir-466b-7, mmu-mir-466p, mmu-mir-466n, mmu-mir-466b-8, rno-mir-466d, mmu-mir-466q, mmu-mir-21b, mmu-mir-21c, mmu-mir-142b, mmu-mir-466c-3, rno-mir-322-2, rno-mir-503-2, rno-mir-466b-3, rno-mir-466b-4, rno-mir-542-2, rno-mir-542-3
Both ACTH and 17α-E2 up-regulated the expression of miRNA-212, miRNA-132, miRNA-154, miRNA-494, miRNA-872, miRNA-194, and miRNA-24-1, but reduced the expression of miRNA-322, miRNA-20b, miRNA-339, miRNA-27a, miRNA-551b, and miRNA-1224. [score:8]
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[+] score: 7
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-16-1, hsa-mir-17, hsa-mir-20a, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-29a, hsa-mir-30a, hsa-mir-93, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, hsa-mir-107, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-15b, mmu-mir-23b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-101a, mmu-mir-124-3, mmu-mir-125a, mmu-mir-130a, mmu-mir-9-2, mmu-mir-135a-1, mmu-mir-136, mmu-mir-138-2, mmu-mir-140, mmu-mir-144, mmu-mir-145a, mmu-mir-146a, mmu-mir-149, mmu-mir-152, mmu-mir-10b, mmu-mir-181a-2, mmu-mir-182, mmu-mir-183, mmu-mir-185, mmu-mir-24-1, mmu-mir-191, mmu-mir-193a, mmu-mir-195a, mmu-mir-200b, mmu-mir-204, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-10a, hsa-mir-10b, hsa-mir-34a, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-182, hsa-mir-183, hsa-mir-204, hsa-mir-181a-1, hsa-mir-221, hsa-mir-222, hsa-mir-200b, mmu-mir-301a, mmu-mir-34c, mmu-mir-34b, mmu-let-7d, mmu-mir-130b, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-30b, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-130a, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-138-2, hsa-mir-140, hsa-mir-144, hsa-mir-145, hsa-mir-152, hsa-mir-191, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125a, hsa-mir-136, hsa-mir-138-1, hsa-mir-146a, hsa-mir-149, hsa-mir-185, hsa-mir-193a, hsa-mir-195, hsa-mir-320a, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-20a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-93, mmu-mir-34a, mmu-mir-330, mmu-mir-340, mmu-mir-135b, mmu-mir-101b, hsa-mir-200c, hsa-mir-181b-2, mmu-mir-107, mmu-mir-10a, mmu-mir-17, mmu-mir-200c, mmu-mir-181a-1, mmu-mir-320, mmu-mir-26a-2, mmu-mir-221, mmu-mir-222, mmu-mir-29b-2, mmu-mir-135a-2, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-7a-1, mmu-mir-7a-2, mmu-mir-7b, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-101-2, hsa-mir-34b, hsa-mir-34c, hsa-mir-301a, hsa-mir-130b, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-361, mmu-mir-361, hsa-mir-376a-1, mmu-mir-376a, hsa-mir-340, hsa-mir-330, hsa-mir-135b, hsa-mir-339, hsa-mir-335, mmu-mir-335, mmu-mir-181b-2, mmu-mir-376b, mmu-mir-434, mmu-mir-467a-1, hsa-mir-376b, hsa-mir-485, hsa-mir-146b, hsa-mir-193b, hsa-mir-181d, mmu-mir-485, mmu-mir-541, hsa-mir-376a-2, hsa-mir-320b-1, hsa-mir-320c-1, hsa-mir-320b-2, mmu-mir-301b, mmu-mir-674, mmu-mir-146b, mmu-mir-467b, mmu-mir-669c, mmu-mir-708, mmu-mir-676, mmu-mir-181d, mmu-mir-193b, mmu-mir-467c, mmu-mir-467d, hsa-mir-541, hsa-mir-708, hsa-mir-301b, mmu-mir-467e, mmu-mir-467f, mmu-mir-467g, mmu-mir-467h, hsa-mir-320d-1, hsa-mir-320c-2, hsa-mir-320d-2, mmu-mir-467a-2, mmu-mir-467a-3, mmu-mir-467a-4, mmu-mir-467a-5, mmu-mir-467a-6, mmu-mir-467a-7, mmu-mir-467a-8, mmu-mir-467a-9, mmu-mir-467a-10, hsa-mir-320e, hsa-mir-676, mmu-mir-101c, mmu-mir-195b, mmu-mir-145b, mmu-let-7j, mmu-mir-130c, mmu-mir-30f, mmu-let-7k, mmu-mir-9b-2, mmu-mir-124b, mmu-mir-9b-1, mmu-mir-9b-3
The miRNA families that change expression in both mouse and human were: let-7, miR-7, miR-15, miR-101, miR-140, miR-152 (all validated by qPCR, P < 0.05), as well as miR-17, miR-34, miR-135, miR-144, miR-146, miR-301, miR-339, miR-368 (qPCR not performed). [score:3]
The miRNA families that change expression in both mice and rats were: mir-7, mir-9, mir-10, mir-15, mir-17, mir-26, mir-29, mir-30, mir-101, mir-130, mir-181, mir-204, mir-339, mir-340, mir-368, mir-434, mir-467. [score:3]
50E-0367mmu-miR-339-5pmir-3390.206.807.92E-037.53E-028mmu-miR-34c-5pmir-340.246.689.54E-066.88E-0477mmu-miR-34a-5pmir-340.179.541.17E-029.66E-0245mmu-miR-340-5pmir-3400.178.511.71E-032.45E-0217mmu-miR-361-5pmir-3610.247.887.74E-052.90E-0319mmu-miR-376b-3pmir-3680.268.451.05E-043.50E-0356mmu-miR-376a-3pmir-3680.1910.215.63E-036.40E-0223mmu-miR-434-3pmir-4340.2210.461.76E-044. [score:1]
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[+] score: 7
A spectrum of miRNAs including miR-337-5p, miR-17-1, miR-15a, miR-491-5p, miR-339, miR-337-3p, miR-241, miR-19a were predicted to down regulate oncogenic targets like TGFβ, BCLXW, BCL-Xl, STATs, c-MYC and SMAD (as represented by red lines). [score:4]
For example, miR-337-5p, miR-17-1, miR-15a, miR-491-5p, miR-339, miR-337-3p, miR-241, miR-19a were found to modulate oncogenic targets including TGFβ, STATs, c-MYC and SMAD. [score:3]
[1 to 20 of 2 sentences]
[+] score: 7
For example, in a glioma mo del, miR-222 and miR-339 were demonstrated to target and inhibit ICAM-1 expression, thus diminishing tumor sensitivity to lysis by cytotoxic T cells [27]. [score:7]
[1 to 20 of 1 sentences]
[+] score: 6
For the miRNAs down-regulated by H9N2, the PB1 segment also mostly reduced their expression, especially for miR339, miR375, and miR146 (Figures 2A,B). [score:6]
[1 to 20 of 1 sentences]
[+] score: 6
miR-339-5p regulates the p53 tumor-suppressor pathway by targeting MDM2. [score:6]
[1 to 20 of 1 sentences]
[+] score: 5
Other miRNAs from this paper: hsa-let-7c, hsa-let-7d, hsa-mir-16-1, hsa-mir-21, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-28, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-99a, hsa-mir-101-1, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-30a, mmu-mir-99a, mmu-mir-101a, mmu-mir-125b-2, mmu-mir-126a, mmu-mir-128-1, mmu-mir-9-2, mmu-mir-142a, mmu-mir-144, mmu-mir-145a, mmu-mir-151, mmu-mir-152, mmu-mir-185, mmu-mir-186, mmu-mir-24-1, mmu-mir-203, mmu-mir-205, hsa-mir-148a, hsa-mir-34a, hsa-mir-203a, hsa-mir-205, hsa-mir-210, hsa-mir-221, mmu-mir-301a, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-125b-1, hsa-mir-128-1, hsa-mir-142, hsa-mir-144, hsa-mir-145, hsa-mir-152, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-125b-2, hsa-mir-126, hsa-mir-185, hsa-mir-186, mmu-mir-148a, mmu-mir-200a, mmu-let-7c-1, mmu-let-7c-2, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-21a, mmu-mir-24-2, mmu-mir-29a, mmu-mir-31, mmu-mir-34a, mmu-mir-148b, mmu-mir-101b, mmu-mir-28a, mmu-mir-210, mmu-mir-221, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-125b-1, mmu-mir-128-2, hsa-mir-128-2, hsa-mir-200a, hsa-mir-101-2, hsa-mir-301a, hsa-mir-151a, hsa-mir-148b, hsa-mir-339, hsa-mir-335, mmu-mir-335, hsa-mir-449a, mmu-mir-449a, hsa-mir-450a-1, mmu-mir-450a-1, hsa-mir-486-1, hsa-mir-146b, hsa-mir-450a-2, hsa-mir-503, mmu-mir-486a, mmu-mir-542, mmu-mir-450a-2, mmu-mir-503, hsa-mir-542, hsa-mir-151b, mmu-mir-301b, mmu-mir-146b, mmu-mir-708, hsa-mir-708, hsa-mir-301b, hsa-mir-1246, hsa-mir-1277, hsa-mir-1307, hsa-mir-2115, mmu-mir-486b, mmu-mir-28c, mmu-mir-101c, mmu-mir-28b, hsa-mir-203b, hsa-mir-5680, hsa-mir-5681a, mmu-mir-145b, mmu-mir-21b, mmu-mir-21c, hsa-mir-486-2, mmu-mir-126b, mmu-mir-142b, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
The 3p arms of miR-28 and miR-339 showed higher expressions than the corresponding 5p arms in the metastatic line, whereas they showed lower expressions than the corresponding 5p arms in the non-metastatic line. [score:5]
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[+] score: 5
Northern blot analysis showed no significant differences in the expression of miR-24 and miR-339 between normal and dystrophic mRNA samples (data not shown). [score:3]
Among the several miRs predicted to bind the β1-syntrophin 3′-UTR, three miRs (miR-222, miR-24, and miR-339) were identified by the different databases utilized. [score:1]
By analyzing this 3′-UTR, we identified putative consensus binding sites for three miRs: miR-24, miR-222 and miR-339. [score:1]
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[+] score: 4
As shown in Table 2, 15 miRNAs (miR-222, miR-320, miR-24, miR-132, let-7b, miR-106a, miR-19b, miR-16, miR-186, miR-339-3p, miR-17, miR-323-3p, miR-197, miR-20a, and miR-382) were down-regulated in Group 2 and were chosen for subsequent verification analysis. [score:4]
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[+] score: 4
The other four miRNAs, miR-339-3p, miR-694, miR-421 and miR-103 were downregulated in symptomatic group with only marginal changes in pre-symptomatic one. [score:4]
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[+] score: 4
Mmu-miR-31, mmu-miR-351, mmu-miR-672, mmu-miR-339-3p, mmu-miR-138, mmu-miR-210, mmu-miR-25, and mmu-miR-322 were found to be more prominent and may play crucial roles in the regulatory network for their degree were more than 5. 10.1371/journal. [score:2]
Mmu-miR-31, mmu-miR-351, mmu-miR-672, mmu-miR-339-3p, mmu-miR-138, mmu-miR-210, mmu-miR-25, and mmu-miR-322 were found to be more prominent and may play crucial roles in the regulatory network for their degree were more than 5. 10.1371/journal. [score:2]
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Among the miRNAs in the plasma, many have been shown to have differential expression in cells or tissue after ionizing radiation, such as miR-142-5p [27], miR-339, hsa-miR-342, hsa-miR146a, hsa-miR-29c, hsa-miR155, hsa-miR-197, hsa-miR-34b [28], and miR-29c [29]. [score:3]
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Additional studies demonstrate altered miRNA expression in CNS tissue following opioid administration; miR-190 (Zheng et al., 2010a), miR-133b (Sanchez-Simon et al., 2010), miR-28, -125b, -150 and -382 (Wang et al., 2011), miR-23b and -339 (Wu et al., 2008, 2009, 2013), miR-339 (Zheng et al., 2012), miR-103 and -107 (Lu et al., 2014), miR-21 and -146a (Strickland et al., 2014), and miR-124 (Qiu et al., 2015). [score:3]
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miR-337-5p + ND miR-339-5p + ND miR-34a + + + + + + + +Regulation of p53 -mediated apoptosis [32]. [score:2]
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The microarray profile revealed that several miRNAs, including miR-328a, miR-99b, miR-210, miR-342, miR-29b, miR-224, and miR-339, were regulated at different time points. [score:2]
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Zone 1 comprises the loop, zone 2 includes the region giving rise to the mature mir-339 sequence (shown in bold), and zone 3 includes sequences (if any) below the mature microRNA. [score:1]
Shown is pre-miR-339. [score:1]
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A total of 54 different miRNA were predicted to bind four sites within 3′UTR, among which mmu-miR-10a, mmu-miR-10b, mmu-miR-761, mmu-miR-214, mmu-miR-670, mmu-miR-877 and mmu-miR-339 were predicted by almost all used tools. [score:1]
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For 2 m, miR142-3p, miR181b, miR181a (also known as miR213) and miR219-5p were validated; and for 6 m, validation was performed for miR142-3p, miR142-5p, miR339 and miR1249 (Fig.   1C). [score:1]
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