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33 publications mentioning rno-mir-7b

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-7b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 44
Other miRNAs from this paper: rno-mir-7a-1, rno-mir-7a-2, rno-mir-451, rno-mir-375
It was reported that ectopic over -expression of miR-7 in glioma cells can down-regulate 14-3-3ζ, indicating that 14-3-3ζ may be a downstream effector of miR-7 [58]. [score:6]
In glioma cells, the over -expression of microRNA-7 (miR-7) down-regulated 14-3-3ζ [14]. [score:6]
To initially explore the molecular mechanisms of apoptosis in NTDs, we investigated the expression of microRNA-7 (miR-7), microRNA-375 (miR-375) and microRNA-451 (miR-451), which are known to down-regulate 14-3-3ζ in several different cell types. [score:4]
Therefore, in this paper, we confirmed the expression of 14-3-3ζ in spinal cords from normal rat fetuses and fetuses with spina bifida from E11 to E19, and selected miR-7, miR-375 and miR-451 as upstream regulators and p53 as the downstream effector of 14-3-3ζ. [score:4]
However, the expression of miR-7, miR-375 and miR-451 in subgroup 2 was similar to that in control fetuses. [score:3]
0070457.g003 Figure 3Expression of miR-7 (A), miR-375 (B) and miR-451 (C) in spinal cords of control group (blue), subgroup 1 (red) and subgroup 2 (pink) embryos at E12, E13 and E15 detected by qRT-PCR. [score:3]
One-way ANOVA was used to evaluate differences in 14-3-3ζ expression (both in mRNA and protein levels), miR-7, miR-375, miR-451 and p53 protein expression among the controls, subgroup 1 and subgroup 2. If a significant P-value was reached, the SNK post-hoc test was used for pairwise comparisons to identify which means were significantly different from one another. [score:3]
To initially explore the mechanism by which 14-3-3ζ is down-regulated in spina bifida, we measured miR-7, miR-375 and miR-451 (upstream regulators of 14-3-3ζ) in normal and defective spinal cords at E12, E13 and E15. [score:3]
Expression of miR-7, miR-375 and miR-451 in spinal cords of rat fetuses. [score:3]
Expression of miR-7 (A), miR-375 (B) and miR-451 (C) in spinal cords of control group (blue), subgroup 1 (red) and subgroup 2 (pink) embryos at E12, E13 and E15 detected by qRT-PCR. [score:3]
In subgroup 2, the expression of miR-7, miR-375 and miR-451 was similar to that in controls (Figure 3, A - miR-7, B - miR-375, C - miR-451). [score:3]
Similarly, the different expression levels of 14-3-3ζ, miR-7, miR-375, miR-451 and p53 among multiple developmental stages were also evaluated by one-way ANOVA and the SNK post-hoc test. [score:2]
U6 (as the endogenous control gene), miR-7, miR-375 and miR-451 cDNA was reverse-transcribed from the total RNA (obtained from the same sample used for the mRNA expression assays) using specific primers and a TaqMan® MicroRNA Reverse Transcription Kit (Applied Biosystems, USA) in accordance with the manufacturer’s instructions. [score:1]
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2
[+] score: 29
Moreover, miR-7 silencing experiments, performed with anti-miR-7 morpholinos, demonstrate an increase in the expression of spata2 mRNA (in ex vivo cultured islets or in the pancreatic β-cell line MIN6) thus confirming that spata2 is down-regulated by miR-7. Since spata2 and miR-7 transcript expression seems to be inversely correlated, it has been proposed that spata2/miR-7 could be involved in islet biogenesis [20]. [score:8]
Bravo-Egana et al. performed a differential expression analysis of miRNAs in human adult acinar and islets pancreatic tissue and identified miR-7 to be the most highly and selectively expressed miRNA in islets, with an islet/acinar ratio of expression greater than 200 [17]. [score:7]
The RNA target predictive algorithms TargetScan, Miranda and PicTar identified spata2 gene as the miR-7 target with the highest rank. [score:7]
Other studies confirmed the major expression of miR-7 during human pancreatic islet development and differentiation and revealed the correlation between its expression and the observed increase in pro-insulin gene transcripts [18, 19]. [score:6]
THE LAST PART OF THE STORY: SPATA2, MIR-7 AND PANCREATIC ISLETS. [score:1]
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3
[+] score: 19
For example, CDR1as (antisense to the cerebellar degeneration-related protein 1 transcript) with circularization into circRNA harboured 73 conserved binding sites for targeting miR-7, so it interacted with miR-7 and strongly suppressed miR-7 activity with resistant to miRNA -mediated target destabilization, resulting in increased levels of miR-7 targets [8]. [score:9]
Hansen et al. found that the circular transcripts of SRY had 18 miR-183 binding sites and that CDR1as had 73 miR-7 binding sites [16], so they proposed scientific hypothesis and demonstrated that circRNA could function as miRNA sponges to regulate the expression of target genes indirectly. [score:7]
Li et al. pointed out that cir-ITCH interacted with 3 molecules of miR-7, miR-17 and miR-214 to increase the level of ITCH and suppress the ESCC [20]. [score:3]
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4
[+] score: 18
Althogether these studies strongly suggest that an up-regulation of most, if not all, members of the let-7 and miR-7 families and of the miR-132/212 cluster marks hypothalamus development while miR-9, miR-124a, miR-145 and miR-219 displayed nucleus-specific regulations of expression. [score:8]
Let-7b, miR-124a and miR-9 displayed no expression differences in MPN between P15 and P30 while let-7a, miR-7, miR-132, miR-145 and miR-219 displayed up-regulations. [score:6]
Our data also established the up-regulation of all members of the let-7 and miR-7 gene families, as well as that of the four miRNAs encoded by the miR-132/212 cluster, i. e. miR-132-3p, miR-132-5p, miR-212-3p and miR-212-5p, when comparing stages P14 and P28. [score:4]
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5
[+] score: 17
Other miRNAs from this paper: rno-mir-7a-1, rno-mir-7a-2, rno-mir-27a, rno-mir-145, rno-mir-146a
For example, miR-7 inhibits the invasion and metastasis of cancer cells by regulating Egfr expression [24– 26]; miR-145 inhibits cell proliferation of lung adenocarcinoma by targeting Egfr [27], miR-146a suppresses tumor growth and progression by targeting Egfr in prostate cancer [28]; miR-27a regulates non-small lung cancer by targeting Egfr [29]. [score:17]
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6
[+] score: 13
For instance, 2.5 Gy of X-rays caused upregulation of miR-34a and downregulation of miR-7 in hematopoietic tissues [9]. [score:7]
Targets for miR-34a are oncogenes myc, notch1, e2f3, and cyclinD1; miR-7 targets a regulator of DNA methylation, a lymphoid-specific helicase (LSH). [score:6]
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7
[+] score: 11
Microarray assay revealed that miR-7 was upregulated in murine hearts after I/R [13]. [score:3]
Previous studies have confirmed that miR-7 inhibits cell proliferation and increases cell apoptosis in some cancers [23]– [26]. [score:3]
miR-7, as a tumor suppressor, reduces proliferation and increases apoptosis of tumour cells such as in malignant neuroblastomas, lung cancer and tongue squamous cell carcinoma [22]– [26]. [score:3]
MicroRNA-7 (miR-7) is highly connected to cancerous cell proliferation and metastasis. [score:1]
We aimed to investigate the role of miR-7 during myocardial I/R injury in vitro and in vivo and a possible gene target. [score:1]
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8
[+] score: 11
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-17, hsa-mir-21, hsa-mir-22, hsa-mir-28, hsa-mir-29b-1, hsa-mir-16-2, mmu-let-7g, mmu-let-7i, mmu-mir-1a-1, mmu-mir-29b-1, mmu-mir-124-3, mmu-mir-9-2, mmu-mir-133a-1, mmu-mir-145a, mmu-mir-150, mmu-mir-10b, mmu-mir-195a, mmu-mir-199a-1, hsa-mir-199a-1, mmu-mir-200b, mmu-mir-206, mmu-mir-143, hsa-mir-10a, hsa-mir-10b, hsa-mir-199a-2, hsa-mir-217, hsa-mir-218-1, hsa-mir-223, hsa-mir-200b, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-1-2, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-143, hsa-mir-145, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-150, hsa-mir-195, hsa-mir-206, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-16-1, mmu-mir-16-2, mmu-mir-21a, mmu-mir-22, mmu-mir-29c, rno-let-7d, rno-mir-329, mmu-mir-329, rno-mir-331, mmu-mir-331, rno-mir-148b, mmu-mir-148b, rno-mir-135b, mmu-mir-135b, hsa-mir-200c, hsa-mir-1-1, mmu-mir-1a-2, mmu-mir-10a, mmu-mir-17, mmu-mir-28a, mmu-mir-200c, mmu-mir-218-1, mmu-mir-223, mmu-mir-199a-2, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-7b, mmu-mir-217, hsa-mir-29c, hsa-mir-200a, hsa-mir-365a, mmu-mir-365-1, hsa-mir-365b, hsa-mir-135b, hsa-mir-148b, hsa-mir-331, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-10a, rno-mir-10b, rno-mir-16, rno-mir-17-1, rno-mir-21, rno-mir-22, rno-mir-28, rno-mir-29b-1, rno-mir-29c-1, rno-mir-124-3, rno-mir-124-1, rno-mir-124-2, rno-mir-133a, rno-mir-143, rno-mir-145, rno-mir-150, rno-mir-195, rno-mir-199a, rno-mir-200c, rno-mir-200a, rno-mir-200b, rno-mir-206, rno-mir-217, rno-mir-223, dre-mir-7b, dre-mir-10a, dre-mir-10b-1, dre-mir-217, dre-mir-223, hsa-mir-429, mmu-mir-429, rno-mir-429, mmu-mir-365-2, rno-mir-365, dre-mir-429a, hsa-mir-329-1, hsa-mir-329-2, hsa-mir-451a, mmu-mir-451a, rno-mir-451, dre-mir-451, dre-let-7a-1, dre-let-7a-2, dre-let-7a-3, dre-let-7a-4, dre-let-7a-5, dre-let-7a-6, dre-let-7b, dre-let-7c-1, dre-let-7c-2, dre-let-7d-1, dre-let-7d-2, dre-let-7e, dre-let-7f, dre-let-7g-1, dre-let-7g-2, dre-let-7h, dre-let-7i, dre-mir-1-2, dre-mir-1-1, dre-mir-9-1, dre-mir-9-2, dre-mir-9-4, dre-mir-9-3, dre-mir-9-5, dre-mir-9-6, dre-mir-9-7, dre-mir-10b-2, dre-mir-16a, dre-mir-16b, dre-mir-16c, dre-mir-17a-1, dre-mir-17a-2, dre-mir-21-1, dre-mir-21-2, dre-mir-22a, dre-mir-22b, dre-mir-29b-1, dre-mir-124-1, dre-mir-124-2, dre-mir-124-3, dre-mir-124-4, dre-mir-124-5, dre-mir-124-6, dre-mir-133a-2, dre-mir-133a-1, dre-mir-133b, dre-mir-133c, dre-mir-143, dre-mir-145, dre-mir-150, dre-mir-200a, dre-mir-200b, dre-mir-200c, dre-mir-206-1, dre-mir-206-2, dre-mir-365-1, dre-mir-365-2, dre-mir-365-3, dre-let-7j, dre-mir-135b, rno-mir-1, rno-mir-133b, rno-mir-17-2, mmu-mir-1b, dre-mir-429b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-9b-2, rno-mir-133c, mmu-mir-28c, mmu-mir-28b, hsa-mir-451b, mmu-mir-195b, mmu-mir-133c, mmu-mir-145b, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, mmu-mir-451b, mmu-let-7k, rno-let-7g, rno-mir-29c-2, mmu-mir-9b-2, mmu-mir-124b, mmu-mir-9b-1, mmu-mir-9b-3
For example, in mouse [14], miR-10b is highly expressed in spinal cord; miR-124 is wi dely expressed in brain tissues; miR-200b, miR-128a, miR-128b, miR-429 are specifically expressed in olfactory bulb; miR-200a is highly expressed in olfactory bulb; miR-7b is highly expressed in hypothalamus. [score:11]
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9
[+] score: 9
Once again the findings highlight the possibilities by which specific miRNAs instruct pathophysiological processes in fatty liver disease with miR-7-5p targeting suppressor of cytokine signalling SOCs and calveolin-1, i. e. an essential component of membrane lipid rafts with complex functions in cell signalling while the subnetwork of let-7b-5p involves translational control of the LDL receptor, hepatic lipoprotein lipase and SNAP23 that forms a complex with other vesicle -associated membrane protein and is part of the fusion machinery in macro-vesicular steatosis. [score:9]
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10
[+] score: 9
For example, Lukiw et al. [12, 13] demonstrated that circRNA-7(ciRS-7) acted as a natural miRNA sponge for miRNA-7 and regulated the expression of ubiquitin-conjugating enzyme E2A (UBE2A) and the epidermal growth factor receptor (EGFR) in sporadic AD hippocampal brain. [score:4]
Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer’s Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7). [score:3]
For example, the circRNA-7/miRNA-7/UBE2A signaling pathway is significantly dysregulated in AD [33, 34]. [score:2]
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11
[+] score: 9
Accumulations of miR-497 in the cerebellum, of miR-7 in the hypothalamus, and of miR-221 and miR-222 in the hippocampus have also been described in mice [39] and zebrafish (larval and adult brain), where miR-222 is expressed in specific groups of differentiating cells in the rostral parts of the brain [42]. [score:3]
It has recently been shown that the insulin-like growth factor 1 (IGF-1) is targeted by miR-206 [49] and that miR-7 is a repressor of insulin receptor substrate 1 (IRS1) and 2 (IRS2) [50]. [score:3]
The close interdependence between the actions of IGF-1 and IRS1/IRS2 suggests that miR-206 and miR-7 could be involved in tissue or cell-specific regulation of the functions mediated by IGF-1-signalling pathways in the brain. [score:2]
One example is a potential functional cross-talk between miR-206 (enriched in the cerebellum) and miR-7 (enriched in the hypothalamus and amygdala). [score:1]
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12
[+] score: 8
miRNA Target Genes Pathways miR-128 ABCB9, BTG1, DSCR1, RASD1 ABC transporters General miR-136 GRN, PPP1R9B miR-147 HOXA1, PTGFRN miR-148 EGR3, SCN3A miR-181b IGF1R, NKX6-1 Adherens junction, Maturity onset diabetes of the, Focal adhesion, **Long term depression miR-196a ABCB9, CPB2, IRS1, MAPK10 ABC transporters General, Complement and coagulation cas, Adipocytokine signaling pathwa, Insulin signaling pathway, Type II diabetes mellitus, Fc epsilon RI signaling pathwa, Focal adhesion, **GnRH signaling pathway, **MAPK signaling pathway, Toll like receptor signaling p, Wnt signaling pathway miR-203 SARA1 miR-20 BTG1, SARA1, YWHAB Cell cycle miR-21 TPM1 mir-216 GNAZ **Long term depression miR-217 RHOA Adherens junction, Axon guidance, Focal adhesion, Leukocyte transendothelial mig, Regulation of actin cytoskelet, TGF beta signaling pathway, T cell receptor signaling path, Tight junction, Wnt signaling pathway miR-31 ATP2B2, DNM1L, EGR3, PPP1R9B, YWHAB **Calcium signaling pathway, Cell cycle miR-7 SLC23A2 miR-7b HRH3, NCDN, SLC23A2 **Neuroactive ligand receptor in b: miRNAs and their targets (from TargetScan and miRanda). [score:8]
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13
[+] score: 8
Eleven of the altered miRNAs were downregulated (miR-122, miR-93*, miR-872, miR-7*, miR-146a, miR-342-3p, miR-150, miR-139, miR-30a, miR-30e, miR-320), whereas three miRNAs, namely miR-463*, miR-34c* and miR-1188, were upregulated in the RYGB group. [score:7]
Furthermore, miR-206, miR-1188, miR-1971 and miR-34c* are inversely correlated with plasma lipid fractions, whereas miR-320 and miR-342-3p and to a lesser extent miR-7*, exhibit a positive correlation. [score:1]
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14
[+] score: 7
Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153. [score:4]
Moreover, three miRNA (miRNA-7, miRNA-9, and miRNA-106b) were found to be associated with neurodegenerative diseases and only one, namely miRNA-9, with intellectual disability (Doxakis, 2010; Wang et al., 2010; Xu et al., 2011; Hu et al., 2017). [score:3]
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15
[+] score: 6
Nieto et al (25) demonstrated that knockdown of miR-7 during early embryonic life resulted in an overall downregulation of insulin production, and decreased β-cell numbers and glucose intolerance in the postnatal period. [score:5]
Among the 19 miRNAs, four miRNAs have already been reported to be correlated to diabetes in previous studies, including miR-29c, let-7a, let-7f and miR-7 (23– 25). [score:1]
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16
[+] score: 6
Over -expression of miR-7 in venous plasma was also demonstrated as a biomarker of schizophrenia [21]. [score:3]
Another venous highly expressed microRNA miR-7 was enriched in nervous system. [score:3]
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17
[+] score: 5
Other miRNAs from this paper: rno-mir-155
Two microRNAs, mir-155 and mir-7b, in particular, have been shown to decrease c-Fos protein levels by suppressing the translation of its mRNA transcript into protein (48, 49). [score:5]
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18
[+] score: 5
For example, miR-7 inhibits the NLRP3/caspase-1 axis in adult neural stem cells (NSCs) to promote subventricular zone neurogenesis [12]. [score:3]
Fan Z Lu M Qiao C Zhou Y Ding JH Hu G MicroRNA-7 enhances subventricular zone neurogenesis by inhibiting NLRP3/Caspase-1 axis in adult neural stem cellsMol Neurobiol 2015 13. [score:2]
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19
[+] score: 5
As shown in Figure  2, miRNAs known to be expressed at high level in beta-cells [26- 28], such as miR-7, miR-29a and miR-146a, were released in exosomes by MIN6B1 cells and human islets. [score:3]
The amount of miR-7, miR-29a and miR-146a recovered in exosomes was measured by qPCR and is expressed as percentage of the corresponding miRNA present inside MIN6B1 cells (A) or human islets (B). [score:1]
As expected, miR-7, miR-29a and miR-146a released by MIN6B1 cells were protected from confirming that they resided inside the exosomes (Figure  2C). [score:1]
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20
[+] score: 5
MiRNA expression was normalised to the level of U6 or miR-7, while mRNA expression was normalised to 18S. [score:5]
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21
[+] score: 5
In addition, the presence of miR-7 in this region may also be significant given that miR-7 inhibits neuronal apoptosis in a cellular Parkinson’s disease mo del (Li et al. 2016) and contributes to the alteration of neuronal morphology and function (Zhang et al. 2015). [score:5]
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22
[+] score: 4
While there was no correlation between LTP magnitude and miRNA fold change (data not shown), five miRNAs were upregulated: miR-132-3p (FC = 1.32 ± 0.08; p = 0.029); miR-7b-5p (FC = 1.38 ± 0.09; p = 0.025); miR-151-3p (FC = 1.16 ± 0.004; p < 0.001); miR-872-5p (FC = 1.48 ± 0.05; p = 0.011); and miR-23a-3p (FC = 1.73 ± 0.05; p = 0.005). [score:4]
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23
[+] score: 4
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-15a, hsa-mir-17, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-29a, hsa-mir-30a, hsa-mir-31, hsa-mir-32, hsa-mir-33a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-106a, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-30a, mmu-mir-30b, mmu-mir-126a, mmu-mir-9-2, mmu-mir-135a-1, mmu-mir-137, mmu-mir-140, mmu-mir-150, mmu-mir-155, mmu-mir-24-1, mmu-mir-193a, mmu-mir-194-1, mmu-mir-204, mmu-mir-205, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-143, mmu-mir-30e, hsa-mir-34a, hsa-mir-204, hsa-mir-205, hsa-mir-222, mmu-let-7d, mmu-mir-106a, mmu-mir-106b, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-137, hsa-mir-140, hsa-mir-143, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-126, hsa-mir-150, hsa-mir-193a, hsa-mir-194-1, mmu-mir-19b-2, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-15a, mmu-mir-23a, mmu-mir-24-2, mmu-mir-29a, mmu-mir-31, mmu-mir-92a-2, mmu-mir-34a, rno-mir-322-1, mmu-mir-322, rno-let-7d, rno-mir-329, mmu-mir-329, rno-mir-140, rno-mir-350-1, mmu-mir-350, hsa-mir-200c, hsa-mir-155, mmu-mir-17, mmu-mir-25, mmu-mir-32, mmu-mir-200c, mmu-mir-33, mmu-mir-222, mmu-mir-135a-2, mmu-mir-19b-1, mmu-mir-92a-1, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-7b, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-106b, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-375, mmu-mir-375, mmu-mir-133b, hsa-mir-133b, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-17-1, rno-mir-19b-1, rno-mir-19b-2, rno-mir-23a, rno-mir-24-1, rno-mir-24-2, rno-mir-25, rno-mir-27b, rno-mir-29a, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-31a, rno-mir-32, rno-mir-33, rno-mir-34a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-106b, rno-mir-126a, rno-mir-135a, rno-mir-137, rno-mir-143, rno-mir-150, rno-mir-193a, rno-mir-194-1, rno-mir-194-2, rno-mir-200c, rno-mir-200a, rno-mir-204, rno-mir-205, rno-mir-222, hsa-mir-196b, mmu-mir-196b, rno-mir-196b-1, mmu-mir-410, hsa-mir-329-1, hsa-mir-329-2, mmu-mir-470, hsa-mir-410, hsa-mir-486-1, hsa-mir-499a, rno-mir-133b, mmu-mir-486a, hsa-mir-33b, rno-mir-499, mmu-mir-499, mmu-mir-467d, hsa-mir-891a, hsa-mir-892a, hsa-mir-890, hsa-mir-891b, hsa-mir-888, hsa-mir-892b, rno-mir-17-2, rno-mir-375, rno-mir-410, mmu-mir-486b, rno-mir-31b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-126b, rno-mir-9b-2, hsa-mir-499b, mmu-let-7j, mmu-mir-30f, mmu-let-7k, hsa-mir-486-2, mmu-mir-126b, rno-mir-155, rno-let-7g, rno-mir-15a, rno-mir-196b-2, rno-mir-322-2, rno-mir-350-2, rno-mir-486, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
Similarly, within the differentially expressed pool of miRNAs, 10 were identified that are intimately involved in regulating intracellular trafficking pathways, including: miR-7b-5p, miR-9-5p, miR-31-5p, miR-92a-3p, miR-106-5p, miR-126-3p, miR-150-5p, miR-204-5p, miR-222-3p, and miR-322-5p (S2 Fig). [score:4]
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[+] score: 4
MiR-375 is one of few miRNAs (along with miR-7) expressed mainly in adult islets and only marginally elsewhere [10]– [13], and controls a cluster of genes regulating cellular growth and proliferation, evident from studies of miR-375 [(−/−)] mice, which are hyperglycemic and have decreased beta-cell mass [11]. [score:4]
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[+] score: 4
Our data revealed that expression levels of miR7 and miR125b were unchanged in ED16, 4W and 14W lenses. [score:3]
In previous research [27, 29, 30], several miRNAs such as miR124, miR7, miR125b and let7b have been detected in rat lens and in regeneration of new lens by transdifferentiation of pigment epithelial cells of the dorsal iris. [score:1]
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26
[+] score: 3
miR-7 binding to a specific circRNA (csRS-7) results in robust derepression of miR-7 mRNA targets in neurons. [score:3]
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27
[+] score: 3
There are several other miRNAs, such as miR-7, miR-124a, miR-9, miR-34a and miR-195, that play a role in the regulation of insulin secretion and β cell development [17]. [score:3]
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28
[+] score: 2
We noted that miRNAs miR-34a, miR-18a, miR-19a, miR-32, miR-96, miR-142-3p miR-29b and miR-7b were significantly upregulated in the AOM rat fecal colonocytes compared to those obtained from the saline controls and the degree of induction was greater in the tumor bearing AOM rats compared to the tumor non-bearing AOM rats (Fig. 3B). [score:2]
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[+] score: 1
Only eleven miRBase miRNAs (4%), i. e. rno-mir-7b, 147, 291a, 297, 327, 335, 347, 340, 349, 352 and 671, were not detected. [score:1]
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30
[+] score: 1
These include miR-7, miR-9, miR-124a, miR-125a/b, miR-181b/c and miR-99a/b. [score:1]
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31
[+] score: 1
Other miRNAs from this paper: cel-let-7, cel-lin-4, hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-29a, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-101-1, hsa-mir-29b-1, hsa-mir-29b-2, mmu-let-7g, mmu-let-7i, mmu-mir-29b-1, mmu-mir-101a, mmu-mir-128-1, mmu-mir-9-2, mmu-mir-132, mmu-mir-138-2, mmu-mir-181a-2, mmu-mir-199a-1, hsa-mir-199a-1, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-181a-2, hsa-mir-181b-1, hsa-mir-181c, hsa-mir-199a-2, hsa-mir-181a-1, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-128-1, hsa-mir-132, hsa-mir-138-2, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-138-1, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-29a, mmu-mir-29c, mmu-mir-92a-2, rno-let-7d, rno-mir-7a-1, rno-mir-101b, mmu-mir-101b, hsa-mir-181b-2, mmu-mir-17, mmu-mir-181a-1, mmu-mir-29b-2, mmu-mir-199a-2, mmu-mir-92a-1, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-138-1, mmu-mir-181b-1, mmu-mir-181c, mmu-mir-128-2, hsa-mir-128-2, mmu-mir-7a-1, mmu-mir-7a-2, mmu-mir-7b, hsa-mir-29c, hsa-mir-101-2, cel-lsy-6, mmu-mir-181b-2, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-7a-2, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-17-1, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-92a-1, rno-mir-92a-2, rno-mir-101a, rno-mir-128-1, rno-mir-128-2, rno-mir-132, rno-mir-138-2, rno-mir-138-1, rno-mir-181c, rno-mir-181a-2, rno-mir-181b-1, rno-mir-181b-2, rno-mir-199a, rno-mir-181a-1, rno-mir-421, hsa-mir-181d, hsa-mir-92b, hsa-mir-421, mmu-mir-181d, mmu-mir-421, mmu-mir-92b, rno-mir-17-2, rno-mir-181d, rno-mir-92b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-9b-2, mmu-mir-101c, mmu-let-7j, mmu-let-7k, rno-let-7g, rno-mir-29c-2, rno-mir-29b-3, mmu-mir-9b-2, mmu-mir-9b-1, mmu-mir-9b-3
The probes used were: EAM119 (miR-29b), EAM125 (miR-138), EAM224 (miR-17-5p), EAM234 (miR-199a), EAM131 (miR-92), EAM109 (miR-7), EAM150 (miR-9) and EAM103 (miR-124a). [score:1]
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[+] score: 1
Choudhury NR Tissue-specific control of brain-enriched mir-7 biogenesisGenes Dev. [score:1]
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[+] score: 1
In 2013, Zhang et al. found that miR-7 might function in the pituitary in pigs, thereby influencing body growth [26]. [score:1]
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