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14 publications mentioning rno-mir-218a-2

Open access articles that are associated with the species Rattus norvegicus and mention the gene name mir-218a-2. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 30
To replicate the findings obtained using TLDA array plate, we selected three miRNAs that were upregulated (mir-124, miR-218, miR-29a) and three, miRNAs that were downregulated (miR-146a, miR-200c, miR-155) based on their highest degree of significance by chronic CORT treatment and re-analyzed their expression individually by qPCR. [score:9]
When most significantly upregulated or downregulated miRNAs (for example, miR-124, miR-218, miR-146a and miR-155) were further analyzed, we found that these miRNAs had at least three simple GR elements (Supplementary Figure 1). [score:7]
Further functional network analysis based on regulatory relationship between miR-124 and miR-218 target genes showed critical genes that have earlier been reported to be the stress-related pathology (Figure 2b). [score:4]
[57] Another synaptic plasticity-related gene CREB is a target of multiple miRNAs (miR-101a, miR-203, miR-218, miR-721, miR-409-5p). [score:3]
As listed in Supplementary Table 6, these genes were predicted targets of miR-124, miR-101, miR-29a, miR-30e, miR-181c, miR-365 and miR-218. [score:3]
For example, miR-218, miR-324-5p, miR-365 and miR-146a were localized on chromosome 10; miR-764-5p and miR-351 on chromosome X; miR-101 and miR-30e on chromosome 5; miR-582 and miR-137 on chromosome 2; miR-153 and miR-203 on chromosome 6; miR-124 and 181a on chromosome 3 and miR-135a*/miR-135a-3p and let-7i on chromosome 7. Some of the miRNAs that were localized on the chromosome and in close proximity showed the same direction of changes. [score:2]
We confirmed this finding by analyzing the six most significant CORT -induced altered miRNAs (miR-218, miR-124, miR-29a, miR-146a, miR-200c, miR-155) by qPCR. [score:1]
We next selected two specific miRNAs—miR-124 and miR-218—which showed the most statistically significant changes in the CORT -treated group. [score:1]
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2
[+] score: 26
Most of the pathways related to the targets of miR-218a-5p were involved in signal transmission or the neuronal system, suggesting that miR-218a-5p regulates vestibular compensation. [score:4]
Most of the pathways related to miR-218a-5p targets were related to signal transmission or the neuronal system. [score:3]
Lastly, we performed pathway analysis of the targets of miR-218a-5p, 219a-5p, and 221-3p. [score:3]
Finally, the miR-218a-5p and 219a-5p groups both showed inhibited recovery of the rotarod scores and decreased neurogenesis in the MVN. [score:3]
The ten most relevant pathways of the targets of miR-218a-5p (a), 219a-5p (b), and 221-3p (c) are shown. [score:3]
Consequently, we concluded that miR-218a-5p, 219a-5p, and 221-3p may be involved in the regulation of vestibular compensation. [score:2]
Artificial cerebrospinal fluid, miR-218a-5p antagomir, miR-219a-5p antagomir, or miR-221-3p agomir were administered into the intracerebroventricular space continuously for 1 week using the brain infusion cannula. [score:1]
miR-218a-5p, 219a-5p, and 221-3p showed significant differences in RQ values between the UVD and SO groups at more than one timepoint. [score:1]
The group treated with the miR-218a-5p, 219a-5p, and 221-3p oligomer showed significant reduction in rotarod scores after surgery (Fig.   3c). [score:1]
Therefore, we believe that the mechanisms through which miR-218a-5p and 219a-5p affect vestibular compensation involve neurogenesis in the MVN, while miR-221-3p appears to be unrelated to neurogenesis. [score:1]
Thirty-six rats were randomly divided into four groups: the control group (n = 9), which received artificial cerebrospinal fluid (aCSF) containing (mm): 124 NaCl, 5 KCl, 1.2 KH [2]PO [4], 1.3 MgSO [4], 2.4 CaCl [2], 26 NaHCO [3] and 10 d-glucose; the 218a-5p group (n = 9), which received the miR-218a-5p antagomir (Qiagen, Hilden, Germany); the 219a-5p group (n = 9), which received the miR-219a-5p antagomir (Qiagen); and the 221-3p group (n = 9), which received the miR-221-3p agomir (Qiagen). [score:1]
was performed for miR-218a-5p (a) 219a-5p (b) and 221-3p (c). [score:1]
However, in the animals in which miR-218a-5p (c) and miR-219a-5p 5p (d) antagomirs were administered, very few BrdU -positive cells were observed. [score:1]
miR-218a-5p, 219a-5p, and 221-3p showed significant differences in RQ values between the UVD and SO groups at more than one timepoint (Fig.   2 and Supplementary Data. [score:1]
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3
[+] score: 26
Specifically, miR-195 potentially regulates vesicle -associated membrane protein 1 (VAMP1), miR-30a targets actinin, alpha 1 (ACTN1), miR-21 targets paired-like homeodomain 2 (PITX2) in D6; miR-132 potentially regulates solute carrier family 2, member 1 (SLC2A1), nuclear receptor subfamily 4, group A, member 2 (NR4A2) and Cdc42 guanine nucleotide exchange factor 9 (ARHGEF9), miR-203 targets calcium binding protein 7 (CABP7), miR-17-5p targets early growth response 2 (EGR2) in S6; miR-330 potentially regulates CD247, nerve growth factor receptor (NGFR) and FAT tumor suppressor homolog 3 (FAT3), miR-338 targets ADAM metallopeptidase domain 17 (ADAM17), miR-218 targets src kinase associated phosphoprotein 1 (SKAP1), miR-185 targets calcium channel, voltage -dependent, N type, alpha 1B subunit (CACNA1B) in S9. [score:20]
Consequently, SCs may alter miRNA expression, including miR-330, miR-218 (in S9) and miR-132 (in S6), to modulate two-way communication between neurons and SCs to maintain structural integrity and functional recovery after axotomy to the peripheral nerves. [score:3]
Especially, SKAP1, the target of miR-218, plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins, which are transmembrane adhesion molecules that mediate cell-cell or cell-extracellular matrix adhesion [47]. [score:3]
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4
[+] score: 13
miR-218a in this study has been predicted to target Zeb2, which is another factor known to suppress EMT. [score:5]
Interestingly, miR-218 has been proved to regulate HMGB1 and suppress migration and invasion. [score:4]
In addition, we demonstrated the down regulation of Zeb2 and the up regulation of miR-218a in parous ALDH positive MECs. [score:3]
miR-497, miR-218a, miR-378 and miR-503 were reported to have anti-carcinogenic effect in breast, glioma, liver, endometrial and gastric cancers respectively. [score:1]
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5
[+] score: 9
Inhibition of FGF signaling through SU5402 -treated primitive streak regions of chick embryos identified up-regulation of let-7b, miR-9, miR-19b, miR-107, miR-130b, miR-148a, miR-203, and miR-218 and down-regulation of miR-29a and miR-489 (Bobbs et al. 2012). [score:9]
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6
[+] score: 5
Notably, a panel of 11 Runx2 -targeting miRNAs (miR-23a, miR-30c, miR-34c, miR-133a, miR-135a, miR-137, miR-204, miR-205, miR-217, miR-218, and miR-338) is expressed in a lineage-related pattern in mesenchymal cell types [20]. [score:5]
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7
[+] score: 4
Figure  2 shows that whilst the expression of miR26a, miR200b, miR214, miR218, and let-7d was not altered in arteries from SHRs compared with NT, a significant increase of miR153 was recorded in SHR MA (8.65, N = 6, P < 0.0001), RA (2.08, N = 6, P < 0.0001), and TA (2.80, N = 6, P < 0.0001). [score:2]
This analysis revealed putative seed sequences in KCNQ4 for miR26a, miR214, miR133a, miR200b, miR153, miR218, and let-7d. [score:1]
In silico analysis of the 3′ UTR of KCNQ4 revealed seed sequences for miR26a, miR133a, miR200b, miR153, miR214, miR218, and let-7d with quantitative polymerase chain reaction showing miR153 increased in those arteries from SHRs that exhibited decreased Kv7.4 levels. [score:1]
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8
[+] score: 4
There were differentially regulated miRNAs identified in this study that did not have a negative correlation, and there were two miRNAs (miR-290, miR-218) that had a significant positive correlation with predicted target mRNAs. [score:4]
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9
[+] score: 3
Study also showed that miR-218 inhibits Robo/Slit pathway to maintain normal vascular function in retina [20]. [score:3]
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10
[+] score: 3
For example, miR-195, miR-497, and miR-30b were found to be enriched in the cerebellum whereas miR-218, miR-221, miR-222, miR-26a, miR-128a/b, miR-138 and let-7c were highly expressed in the HIP. [score:3]
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11
[+] score: 2
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-21, hsa-mir-26b, hsa-mir-27a, hsa-mir-29a, hsa-mir-30a, hsa-mir-33a, hsa-mir-98, hsa-mir-29b-1, hsa-mir-29b-2, mmu-let-7g, mmu-let-7i, mmu-mir-27b, mmu-mir-29b-1, mmu-mir-30a, mmu-mir-30b, mmu-mir-126a, mmu-mir-133a-1, mmu-mir-135a-1, mmu-mir-141, mmu-mir-194-1, mmu-mir-200b, hsa-mir-30c-2, hsa-mir-30d, mmu-mir-30e, hsa-mir-203a, hsa-mir-211, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-200b, mmu-mir-300, mmu-let-7d, hsa-let-7g, hsa-let-7i, hsa-mir-27b, hsa-mir-30b, hsa-mir-133a-1, hsa-mir-133a-2, hsa-mir-135a-1, hsa-mir-135a-2, hsa-mir-141, hsa-mir-194-1, mmu-mir-30c-1, mmu-mir-30c-2, mmu-mir-30d, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-21a, mmu-mir-26b, mmu-mir-29a, mmu-mir-29c, mmu-mir-27a, mmu-mir-98, mmu-mir-326, rno-mir-326, rno-let-7d, rno-mir-343, rno-mir-135b, mmu-mir-135b, hsa-mir-200c, mmu-mir-200c, mmu-mir-218-1, mmu-mir-218-2, mmu-mir-33, mmu-mir-211, mmu-mir-29b-2, mmu-mir-135a-2, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-29c, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-326, hsa-mir-135b, mmu-mir-133a-2, mmu-mir-133b, hsa-mir-133b, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-21, rno-mir-26b, rno-mir-27b, rno-mir-27a, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-33, rno-mir-98, rno-mir-126a, rno-mir-133a, rno-mir-135a, rno-mir-141, rno-mir-194-1, rno-mir-194-2, rno-mir-200c, rno-mir-200a, rno-mir-200b, rno-mir-203a, rno-mir-211, rno-mir-218a-1, rno-mir-300, hsa-mir-429, mmu-mir-429, rno-mir-429, hsa-mir-485, hsa-mir-511, hsa-mir-532, mmu-mir-532, rno-mir-133b, mmu-mir-485, rno-mir-485, hsa-mir-33b, mmu-mir-702, mmu-mir-343, mmu-mir-466b-1, mmu-mir-466b-2, mmu-mir-466b-3, hsa-mir-300, mmu-mir-511, rno-mir-466b-1, rno-mir-466b-2, rno-mir-532, rno-mir-511, mmu-mir-466b-4, mmu-mir-466b-5, mmu-mir-466b-6, mmu-mir-466b-7, mmu-mir-466b-8, hsa-mir-3120, rno-mir-203b, rno-mir-3557, rno-mir-218b, rno-mir-3569, rno-mir-133c, rno-mir-702, rno-mir-3120, hsa-mir-203b, mmu-mir-344i, rno-mir-344i, rno-mir-6316, mmu-mir-133c, mmu-mir-21b, mmu-let-7j, mmu-mir-21c, mmu-mir-30f, mmu-let-7k, mmu-mir-3569, rno-let-7g, rno-mir-29c-2, rno-mir-29b-3, rno-mir-466b-3, rno-mir-466b-4, mmu-mir-203b
By the same method, we found that MRAK081523 and Plxna4 had the same MREs for miR-218, miR-141, miR-98 and let-7. Plxna4 reportedly promotes tumour progression and tumour angiogenesis by enhancing VEGF and basic fibroblast growth factor signalling [44]. [score:1]
113 −0.23 161 −20.19 TRUE rno-miR-218a-5p MIMAT0000888 1 7mer-m8 −0.105 −0.156 162 −17.51 TRUE rno-miR-141-3p MIMAT0000846 1 offset 6mer −0.021 −0.022 141 −13.96 TRUE Identity: the name of the mature miRNA in miRBase v20 Accession: the mature accession id used in miRBase v20 Site No. [score:1]
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12
[+] score: 2
In line with previous studies in mice, we also found moderate enrichment of miR-195 [39], [40] in the cerebellum and of miR-218 in the hippocampus [39] (Figure S2). [score:1]
In all, we found moderate (three-fold) region-specific enrichment of 48 miRNAs (e. g. miR-138, miR-195 and miR-218, Figure S2). [score:1]
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13
[+] score: 1
Most changes were modest in magnitude, with two–thirds showing a fold change less than ±0.40 and only four miRNA (miR-181c-5p, miR-19b-3p, miR-218a-5p, miR-9a-5p) showing more than a twofold change. [score:1]
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14
[+] score: 1
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-16-1, hsa-mir-17, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-30a, hsa-mir-31, hsa-mir-96, hsa-mir-99a, hsa-mir-16-2, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-182, hsa-mir-183, hsa-mir-211, hsa-mir-217, hsa-mir-218-1, hsa-mir-218-2, hsa-mir-221, hsa-mir-222, hsa-let-7g, hsa-let-7i, hsa-mir-15b, hsa-mir-23b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-132, hsa-mir-143, hsa-mir-145, hsa-mir-191, hsa-mir-125a, hsa-mir-125b-2, hsa-mir-126, hsa-mir-184, hsa-mir-190a, hsa-mir-195, rno-mir-322-1, rno-let-7d, rno-mir-335, rno-mir-342, rno-mir-135b, hsa-mir-30c-1, hsa-mir-299, hsa-mir-30e, hsa-mir-26a-2, hsa-mir-379, hsa-mir-382, hsa-mir-342, hsa-mir-135b, hsa-mir-335, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-15b, rno-mir-16, rno-mir-17-1, rno-mir-21, rno-mir-23a, rno-mir-23b, rno-mir-24-1, rno-mir-24-2, rno-mir-25, rno-mir-26a, rno-mir-26b, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-31a, rno-mir-96, rno-mir-99a, rno-mir-125a, rno-mir-125b-1, rno-mir-125b-2, rno-mir-126a, rno-mir-132, rno-mir-143, rno-mir-145, rno-mir-183, rno-mir-184, rno-mir-190a-1, rno-mir-191a, rno-mir-195, rno-mir-211, rno-mir-217, rno-mir-218a-1, rno-mir-221, rno-mir-222, rno-mir-299a, hsa-mir-384, hsa-mir-20b, hsa-mir-409, hsa-mir-412, hsa-mir-489, hsa-mir-494, rno-mir-489, rno-mir-412, rno-mir-543, rno-mir-542-1, rno-mir-379, rno-mir-494, rno-mir-382, rno-mir-409a, rno-mir-20b, hsa-mir-542, hsa-mir-770, hsa-mir-190b, hsa-mir-543, rno-mir-466c, rno-mir-17-2, rno-mir-182, rno-mir-190b, rno-mir-384, rno-mir-673, rno-mir-674, rno-mir-770, rno-mir-31b, rno-mir-191b, rno-mir-299b, rno-mir-218b, rno-mir-126b, rno-mir-409b, rno-let-7g, rno-mir-190a-2, rno-mir-322-2, rno-mir-542-2, rno-mir-542-3
Similarly, stepwise artificial neural networks analysis revealed predictive miRNA signatures (miR-342, miR-299, miR-217, miR-190, miR-135b, miR-218) corresponding to oestrogen receptor status in breast cancer [39]. [score:1]
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