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miRBase |
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![]() 9 publications mentioning rno-mir-291aOpen access articles that are associated with the species Rattus norvegicus and mention the gene name mir-291a. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary. |
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The expression level of miR-291a-3p associated with the susceptibility of rats to the learned helplessness paradigm e. g. increased expression in NLH animals and decreased expression in LH animals.
[score:7]
The expression pattern of miR-291a shows an upregulation in NLH rats and a dowregulation in LH rats, compared to controls.
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As mentioned previously, the expression pattern for miR-291a and miR-367 correlates with the response to LH, while miR-18b is regulated in response to footshock in general.
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Strikingly, we observe recurrent hits on, neutrophin signaling, and ErbB signaling from the predicted targets of miR-18b, miR-291a, miR-760, and miR-367.
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Displaying the most significant KEGG pathways predicted to be targeted by the indicated miRNAs for A) miR-18b-5p, B) miR-291-3p, C) miR-760-5p and D) miR-367-3p.
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The ErbB pathway was found in the target analysis of miR-291a and miR-18b in the MHb.
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The neurotrophin pathway appears in the target analysis of miR-18b and miR-291a of the MHb and in miR-367 of the LHb.
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However, this is contradicted by the expression pattern of miR-291a in the MHb, which associates with the behavioural response to the LH paradigm.
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The expression patterns of miR-291a and miR-367 are particularly interesting.
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0160318.g005 Fig 5Displaying the most significant KEGG pathways predicted to be targeted by the indicated miRNAs for A) miR-18b-5p, B) miR-291-3p, C) miR-760-5p and D) miR-367-3p.
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Two of these were from the MHb analysis; miR-18b, miR-291a and the other two were from the LHb analysis; miR-760, miR-367.
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Follow-up studies are needed to show whether manipulating miRNA’s such as miR-291a and miR-367 associate with stress coping abilities in resilient rats.
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miR-18b-5p and miR-291-3p were identified in the medial habenula.
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Other miRNAs from this paper: rno-mir-7a-1, rno-mir-7a-2, rno-mir-7b, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-19a, rno-mir-92a-1, rno-mir-92a-2, rno-mir-99a, rno-mir-125a, rno-mir-145, rno-mir-181b-1, rno-mir-181b-2, rno-mir-183, rno-mir-199a, rno-mir-218a-2, rno-mir-218a-1, rno-mir-222, rno-mir-290, rno-mir-292, rno-mir-363, rno-mir-92b, rno-mir-291b, rno-mir-9b-3, rno-mir-218b, rno-mir-9b-1, rno-mir-9b-2
Notably, we found miR-222, miR-291-3p, miR-183, miR-363-3p, miR-92, miR-19a and miR-145 as down-regulated miRNAs between E11 and E13 and whose expression was negatively correlated with the expression of their predicted targets.
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Additional support for this hypothesis was provided by the miRNA-TF mRNA network analysis in Figure 8. We found four down-regulated miRNAs (miR-92, miR-183, miR-222 and miR-291-3p) that were predicted to target multiple TFs, which were up-regulated in E13 ENPs.
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Focusing on the down-regulated miRNAs that had a significant negative correlation in Figure 6, we performed network analysis and identified miR-92, miR-183, miR-222 and miR-291-3p as predicted to target multiple TFs that were up-regulated in E13 ENPs (Figure 8).
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The number of mRNAs down-regulated between E11 and E13 encoding proteins involved in cell cycle regulation (see additional file 3), and the expression of miR-290, miR-291-3p, and miR-292-3p, are interpreted as an indication of the proliferative phenotype of the E11 ENPs, which likely contain cells that are only a cell division away from neural stem cells.
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Other miRNAs from this paper: rno-let-7d, rno-mir-329, rno-mir-341, rno-mir-352, rno-mir-21, rno-mir-27a, rno-mir-29b-2, rno-mir-29b-1, rno-mir-30c-1, rno-mir-30e, rno-mir-30b, rno-mir-30d, rno-mir-30a, rno-mir-30c-2, rno-mir-98, rno-mir-100, rno-mir-127, rno-mir-145, rno-mir-181a-2, rno-mir-183, rno-mir-200c, rno-mir-181a-1, rno-mir-299a, rno-mir-483, rno-mir-377, rno-mir-1, rno-mir-133b, rno-mir-503-1, rno-mir-497, rno-mir-495, rno-mir-92b, rno-mir-490, rno-mir-653, rno-mir-675, rno-mir-665, rno-mir-294, rno-mir-3594, rno-mir-155, rno-mir-503-2, rno-mir-29b-3
rno-miR-675-5p 4.143757751 Premature senescence of cardiac progenitor cells, G1 arrest, reduced cell proliferation, colony formation, migration and invasion rno-miR-183-3p 3.74730108 Regulates claudin-1 expression rno-miR-299a-5p 3.626723224 Anti-apoptotic role rno-miR-200c-3p 3.593610443 Targets the VEGF-VEGFR2 pathway and angiogenesis rno-miR-665 3.511737089 Negatively targets anti-apoptotic BCL2L1 rno-miR-291a-5p 3.457928187 VSMC migration rno-miR-490-5p 2.373358 Tumour suppressor rno-miR-1 2.505729 Suppresses cell growth rno-miR-133b 2.192279 Inhibits cell proliferation and invasion rno-miR-30c-1-3p 2.70761 Suppresses PXR expression rno-miR-294 2.010496 Promotes proliferation and differentiation rno-miR-127-5p 2.780488 A regulator of MMP-13 and suppresses cell growth rno-miR-503 2.327383 Inhibits cell proliferation and invasion Table 2 Twenty down-regulated miRNAs.
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Other miRNAs from this paper: rno-mir-322-1, rno-mir-324, rno-let-7d, rno-mir-338, rno-mir-352, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-17-1, rno-mir-18a, rno-mir-19b-1, rno-mir-19b-2, rno-mir-21, rno-mir-23b, rno-mir-25, rno-mir-27a, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-30c-1, rno-mir-30c-2, rno-mir-31a, rno-mir-34b, rno-mir-34a, rno-mir-106b, rno-mir-124-3, rno-mir-124-1, rno-mir-124-2, rno-mir-125b-1, rno-mir-125b-2, rno-mir-126a, rno-mir-137, rno-mir-142, rno-mir-144, rno-mir-145, rno-mir-146a, rno-mir-154, rno-mir-181a-2, rno-mir-199a, rno-mir-181a-1, rno-mir-214, rno-mir-219a-1, rno-mir-219a-2, rno-mir-221, rno-mir-223, rno-mir-433, rno-mir-451, rno-mir-501, rno-mir-376b, rno-mir-363, rno-mir-20b, rno-mir-466c, rno-mir-17-2, rno-mir-484, rno-mir-500, rno-mir-672, rno-mir-146b, rno-mir-293, rno-mir-496, rno-mir-126b, rno-mir-219b, rno-let-7g, rno-mir-322-2, rno-mir-29b-3
Caspase-3 was a potential target of the downregulated miR-376b-3p, calpain 2 was a potential target of the upregulated miR-199a-3p, and iNOS was a potential target of downregulated miR-291a-5p (Figure 4B).
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The predicted target gene of downregulated miR-291a-5p was inducible nitric oxide synthase (iNOS).
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Other miRNAs from this paper: mmu-mir-186, hsa-mir-208a, mmu-mir-291a, mmu-mir-294, mmu-mir-295, mmu-mir-302a, hsa-mir-186, mmu-mir-208a, hsa-mir-302a, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, rno-mir-186, rno-mir-208a, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, rno-mir-294, rno-mir-295-1, rno-mir-295-2
Among these four miRNAs, only miR-291a-3p was upregulated in the lead-treatment alone group, in which the expression of Uc.
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Analysis of miRSystem revealed among the eight miRNAs, four miRNAs (miR-291a-3p, miR-295-3p, miR-302b-3p and miR-302d-3p) have apoptosis -associated target genes (PI3K, NIK and Cn) or a DNA-damage repair -associated target gene (RAD23B).
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173 likely inhibits apoptosis through the mediation of miR-291a-3p, which needs further studies to verify.
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173 potentially regulated apoptosis through the mediation of miR-291a-3p.
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173 (miR-186-5p, miR-208a-5p, miR-291a-3p, miR-294-3p, miR-295-3p, miR-302a-3p, miR-302b-3p, miR-302c-3p and miR-302d-3p).
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Other miRNAs from this paper: hsa-mir-26a-1, hsa-mir-26b, mmu-mir-141, mmu-mir-199a-1, hsa-mir-199a-1, mmu-mir-200b, mmu-mir-205, hsa-mir-199a-2, hsa-mir-199b, hsa-mir-205, hsa-mir-200b, mmu-mir-290a, mmu-mir-291a, mmu-mir-292a, mmu-mir-293, mmu-mir-294, mmu-mir-295, mmu-mir-302a, hsa-mir-141, mmu-mir-200a, mmu-mir-26a-1, mmu-mir-26b, hsa-mir-200c, mmu-mir-200c, mmu-mir-26a-2, mmu-mir-199a-2, mmu-mir-199b, hsa-mir-200a, hsa-mir-302a, hsa-mir-26a-2, hsa-mir-302b, hsa-mir-302c, hsa-mir-302d, hsa-mir-367, hsa-mir-372, rno-mir-26a, rno-mir-26b, rno-mir-141, rno-mir-199a, rno-mir-200c, rno-mir-200a, rno-mir-200b, rno-mir-205, rno-mir-290, rno-mir-292, hsa-mir-429, mmu-mir-429, rno-mir-429, mmu-mir-463, mmu-mir-465a, mmu-mir-471, mmu-mir-367, mmu-mir-291b, mmu-mir-302b, mmu-mir-302c, mmu-mir-302d, mmu-mir-741, mmu-mir-743a, mmu-mir-743b, mmu-mir-871, mmu-mir-880, mmu-mir-881, mmu-mir-883a, mmu-mir-883b, mmu-mir-465b-1, mmu-mir-465b-2, mmu-mir-465c-1, mmu-mir-465c-2, mmu-mir-878, rno-mir-743b, rno-mir-871, rno-mir-878, rno-mir-880, rno-mir-881, rno-mir-883, rno-mir-463, rno-mir-471, rno-mir-743a, hsa-mir-302e, hsa-mir-302f, rno-mir-293, rno-mir-294, rno-mir-295-1, rno-mir-465, rno-mir-3551, rno-mir-291b, rno-mir-3580, rno-mir-741, rno-mir-295-2, rno-mir-6325, mmu-mir-292b, mmu-mir-465d, mmu-mir-290b
Members of the miR-290-295 cluster (miR-290, miR-291a, miR-292, miR-291b, miR-293, miR-294 and miR-295-1) were the most abundant among known miRNAs that were upregulated in rat PSCs.
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Some miRNAs, such as miR-291, miR-294 and miR-295, can enhance reprogramming that is induced by OSK factors [22].
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Other miRNAs from this paper: rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-34a, rno-mir-130a, rno-mir-206, rno-mir-294, rno-mir-291b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-9b-2, rno-mir-29c-2, rno-mir-29b-3
Among those differently expressed microRNAs, miR-291a-5p, mir-294, miR-29a, and miR-29b were further detected by qRT-PCR, and the results were consistent with the microRNA array analysis (Fig. 2C).
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Other miRNAs from this paper: rno-mir-324, rno-let-7d, rno-mir-347, rno-mir-351-1, rno-let-7f-1, rno-let-7f-2, rno-mir-21, rno-mir-25, rno-mir-29b-2, rno-mir-29a, rno-mir-29b-1, rno-mir-29c-1, rno-mir-187, rno-mir-199a, rno-mir-212, rno-mir-292, rno-mir-298, rno-mir-365, rno-mir-431, rno-mir-370, rno-mir-487b, rno-mir-363, rno-mir-20b, rno-mir-466b-1, rno-mir-466b-2, rno-mir-743a, rno-mir-511, rno-mir-615, rno-mir-29c-2, rno-mir-351-2, rno-mir-29b-3, rno-mir-466b-3, rno-mir-466b-4
analysis confirmed the direction and amplitude of all miRNA changes with the exception of let-7d, miR-25*, miR-187, miR-291a-5p, miR-292-5p, miR-365, miR-431, miR-487b, miR-615-5p, miR-743a, miR-20b-3p, miR-199a-3p which remained unaltered or showed no statistical significance.
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Other miRNAs from this paper: rno-mir-326, rno-let-7d, rno-let-7a-1, rno-let-7a-2, rno-let-7b, rno-let-7c-1, rno-let-7c-2, rno-let-7e, rno-let-7f-1, rno-let-7f-2, rno-let-7i, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-19b-1, rno-mir-19b-2, rno-mir-21, rno-mir-34a, rno-mir-124-3, rno-mir-124-1, rno-mir-124-2, rno-mir-128-1, rno-mir-128-2, rno-mir-139, rno-mir-145, rno-mir-146a, rno-mir-206, rno-mir-210, rno-mir-378a, rno-mir-146b, rno-mir-9b-3, rno-mir-9b-1, rno-mir-9b-2, rno-mir-378b, rno-let-7g
In addition, the neural progenitor cells isolated by LCM exhibited increases in miR-146a, miR-146b, miR-210, miR-19b and miR-378 and decreases in miR-128, miR-291a-3p, and miR-139-5p (Fig. 3A to 3C), which are consistent with the array data findings.
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