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26 publications mentioning gga-mir-133a-1

Open access articles that are associated with the species Gallus gallus and mention the gene name mir-133a-1. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

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[+] score: 131
Co-transfection of a BAF60a sensor with miR-133 led to downregulation of luciferase expression compared with co-transfection with miR-140, an unrelated miRNA not predicted to target the 3′UTR. [score:7]
These results indicate that, following myotome formation and myoblast commitment, miR-133 and miR-1/206 negatively regulate BAF60a and BAF60b variants by preventing the translation of residual transcripts expressed in progenitors at earlier developmental stages. [score:7]
The function of miR-133 or miR-1/miR-206 was inhibited by injection of specific antagomirs into somites of HH14-15 embryos, which were analyzed after 24 h. Northern blots of pooled somites showed that antagomir-133 inhibited miR-133 expression (supplementary material Fig. S4A). [score:7]
Mouse BAF60a and BAF60b expression vectors (MRC Geneservice) and GFP plasmid were used for targeted misexpression in vivo at a ratio of 5:1. Mouse NIH3T3 cells in DMEM, 10% FBS, 1% pen/strep were transfected with miR-206, miR-1 or miR-133 (50 nM; Sigma) with and without antimiRs (100 nM; Ambion) using Lipofectamine 2000. [score:7]
To examine the regulation of endogenous BAF60a and BAF60b transcripts by miRNAs in a physiological context and in a different species we used mouse NIH3T3 cells, which express all BAF60 variants (supplementary material Fig. S3B), but do not express the myomiRs miR-133, miR-1 or miR-206. [score:6]
We identify the chromatin remo deling factor BAF60a as an important target for miR-133 and show that BAF60b is an important target for miR-1/206, not only in myogenic C2C12 cells (Goljanek-Whysall et al., 2012b) but also in embryonic myoblasts in developing somites. [score:5]
In vertebrate embryos, miR-206 expression is restricted to skeletal myoblasts in somites, limb buds and head muscles, whereas miR-1 and miR-133 are expressed in developing skeletal muscle and heart (Darnell et al., 2006; Sweetman et al., 2006, 2008). [score:5]
Interestingly, antagomir -mediated inhibition of miR-133 in somites led to complete loss of myogenin expression in the majority of embryos (85%). [score:5]
Co-transfection of miR-133, miR-1 or miR-206 led to downregulation of luciferase expression compared with controls. [score:5]
Chicken BAF60a and BAF60b 3′UTR sensor constructs containing target sites for either miR-133 or miR-1/206 were efficiently targeted by miR-133 or miR-1/206 (Fig.  3C; supplementary material Fig. S3C). [score:5]
Fig. 3. miR-133 and miR-1/206 regulate the expression of BAF60a and BAF60b variants. [score:4]
Here, we reveal the expression of BAF60 variants in embryonic somites and uncover the negative regulation of BAF60a and BAF60b by the myomiRs miR-1/206 and miR-133 during the commitment and differentiation of embryonic myoblasts. [score:4]
Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. [score:4]
In somites and C2C12 myoblasts, MRFs regulate miR-1, miR-206 and miR-133 expression (Rao et al., 2006; Rosenberg et al., 2006; Sweetman et al., 2008). [score:4]
To test whether BAF60a and BAF60b are directly targeted by miR-133 and by miR-1 or miR-206 respectively, sensor constructs were generated with 3′UTR fragments containing putative miRNA binding sites downstream of luciferase (Fig.  3C). [score:4]
Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133. [score:3]
The seed sequence of miR-133 is complementary to the predicted target site in the BAF60a 3′UTR and this is conserved in all three species. [score:3]
This confirmed that miR-133 transfection led to reduced BAF60a expression but did not affect the levels of the other two variants. [score:3]
In situ hybridization shows that miR-1, miR-206 and miR-133 are expressed in the myotome (Fig.  3B; see also Goljanek-Whysall et al., 2011; Sweetman et al., 2008). [score:3]
We next analyzed the effects of miR-133 inhibition in maturing somites. [score:3]
Specific antagomirs inhibiting miR-133 or miR-1/206 were injected into somites on one side of the embryo at HH14-15. [score:3]
Finally, we examined whether increased BAF60a and BAF60b protein levels, after antagomir -mediated inhibition of miR-133 or miR-1/206, altered the composition of BAF/Brg1 complexes. [score:3]
Mutant constructs had BamHI or SalI sites within miR-1/206 or miR-133 target sites. [score:3]
Expression of BAF60c was unaffected by miR-133 or miR-1/206 (supplementary material Fig. S3B). [score:3]
BAF60a variant was elevated after miR-133 inhibition. [score:3]
Inhibition of miR-133 or miR-1/miR-206 abrogates myogenesis and alters BAF/Brg1 subunit composition. [score:3]
These data suggest that miR-133, miR-1 and miR-206 affect the composition of BAF/Brg1 chromatin remo deling complexes through post-transcriptional regulation of BAF60a and BAF60b variants during somite differentiation. [score:2]
We show here for the first time that the amount of BAF60a and BAF60b variants bound to Brg1 decreases during somite differentiation, and our experiments suggest that negative post-transcriptional regulation, mediated by miR-1/206 and miR-133, is necessary for the timely progression of myogenic differentiation. [score:2]
Here, using complementary in vitro and in vivo assays, we identified BAF60a and BAF60b as key targets of the myomiRs miR-1/206 and miR-133 during initiation of the myogenic differentiation program in embryogenesis. [score:2]
Genetic deletion of miR-133a-1 and miR-133a-2 in muscle leads to an adult-onset centronuclear myopathy, which correlates with the dysregulation of dynamin 2 (DNM2). [score:2]
The present study extends this work to assess the role of the miR-1/206 and miR-133 cluster in later somite differentiation (HH14-15). [score:1]
In embryonic stem cells (ESCs), miR-1 and miR-133 promote mesoderm differentiation (Ivey et al., 2008), and transcriptomic analyses in zebrafish have revealed their importance for sarcomeric actin organization (Mishima et al., 2009). [score:1]
Members of the miR-1/206 family are produced from the same primary transcripts as members of the miR-133 family. [score:1]
In skeletal muscle, two highly conserved miRNA families, miR-1/206 and miR-133, play important roles in proliferation, differentiation and cell fate specification; therefore, they have been termed myomiRs (McCarthy, 2008; van Rooij et al., 2008). [score:1]
We propose that, following myoblast commitment, miRNA -mediated post-transcriptional repression of residual BAF60a and BAF60b transcripts is a key event by which miR-133 and miR-1/206 stabilize the myogenic differentiation program in the embryo. [score:1]
Alignments show that a putative miR-133 binding site, with a seed sequence conserved between chick (Gallus gallus, Gga), human (Homo sapiens, Hsa) and mouse (Mus musculus, Mmu), is present in the 3′UTR of the BAF60a gene. [score:1]
Transfection with miR-133 led to reduced BAF60a protein levels; co-transfection of miR-133 with antimiR-133 restored BAF60a protein levels to that of mock transfected controls. [score:1]
The chicken BAF60a 3′UTR sensor did not respond to miR-1 or miR-206, and the BAF60b 3′UTR sensor did not respond to miR-133 (supplementary material Fig. S3C). [score:1]
The effect of miR-133 or a combination of miR-1 and miR-206 on transcript levels of all BAF60 variants was also examined by qPCR. [score:1]
This illustrates the essential role of miR-133a in the maintenance of adult skeletal muscle structure and myofiber identity (Liu et al., 2011). [score:1]
Furthermore, PCR experiments showed that antagomir-1 and antagomir-206 led to loss of miR-1 and miR-206, but had no effect on miR-133, and antagomir-133 specifically affected miR-133 and had no effect on miR-1 or miR-206 (supplementary material Fig. S4B,C). [score:1]
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[+] score: 63
Expression of miR-133 is up-regulated in response to increased expression of myogenin, a myogenic transcription factor which transactivates miR-133 in the presence of exogenous IGF-1. Overexpression of miR-133 has important implications on the IGF-1R/PI3K/Akt signaling pathway due to its ability to block IGF-1R expression and sequentially decrease regulation of Akt phosphorylation, miR-1 overexpression gives rise to pronounced down-regulation of phospho-Akt supported by a generalized decrease in the IGF-1 signal transduction pathway. [score:18]
In contrast, miR-133 overexpression inhibits myoblast differentiation, but promotes myoblast proliferation by targeting SRF, a regulator of miR-133 transcription [39]. [score:8]
Expression of miR-133 was lower than that of miR-206 and showed significant differences, miR-1a expression was high in both libraries and showed significant differences in expression as well. [score:7]
Some miRNAs are expressed ubiquitously in different tissues, while some are expressed in a tissue-specific manner; miR-1, miR-133, and miR-206 belong to the latter category. [score:5]
Both miR-133a and miR-1a were more important during later stages of development than during early stages of development since expression of both increased from 14 to 49 d and decreased from 0 to 14 d. Divergent muscle growth rate is the most common characteristic in commercial chicken lines, particularly in broilers and layers, normal, and SLD chickens. [score:3]
Wang et al. identified 32 known miRNAs from skeletal muscle of Arbor Acres commercial chickens, of which 12 form five clusters: miR-133a-1-miR-1a-2, miR-23b-miR-24, miR-99a-let-7c, miR-92-miR-19b-miR-18a-miR-17, and miR-30e-miR-30c-1, suggesting that most miRNAs co-express in skeletal muscle [85]. [score:3]
Similarly, inhibiting mTOR by rapamycin elicits a sharp decrease in miR-133 and miR-206 [58]. [score:3]
3.4Wang et al. identified 32 known miRNAs from skeletal muscle of Arbor Acres commercial chickens, of which 12 form five clusters: miR-133a-1-miR-1a-2, miR-23b-miR-24, miR-99a-let-7c, miR-92-miR-19b-miR-18a-miR-17, and miR-30e-miR-30c-1, suggesting that most miRNAs co-express in skeletal muscle [85]. [score:3]
Both miR-133a and miR-1a were more important during later stages of development than during early stages of development since expression of both increased from 14 to 49 d and decreased from 0 to 14 d. Divergent muscle growth rate is the most common characteristic in commercial chicken lines, particularly in broilers and layers, normal, and SLD chickens. [score:3]
Moreover, miR-1 and miR-133 can regulate myogenesis via phosphatidylinositol 3-kinase/v-AKT murine thymoma viral oncogene (Akt) (PI3K/Akt) signaling Fig. (1), which at least partially participates in muscle growth and hypertrophy [59]. [score:2]
Moreover, inverse regulation of miR-133 and IGF-1R was observed during C2C12 skeletal muscle cell differentiation [62]. [score:2]
As described above, miR-1 and miR-133 are involved in skeletal muscle growth and development. [score:2]
Gga-miR-1a and gga-miR-1c differ in their 3′ ends and middle sequences by one nucleotide, while gga-miR-133a and gga-miR-133c differ in their 3′ end sequences by only one nucleotide. [score:1]
For example, subtle sequence variations exist within the gga-miR-1 and gga-miR-133 genes, but none exist for gga-miR-206 (http://www. [score:1]
A bicistronic gene cluster encoding miR-1 and miR-133a, and another encoding miR-133b and miR-206 are transcribed from non-coding regions on mouse chromosomes 2 and 1, respectively. [score:1]
Many growth-related miRNAs have been discovered, including miR-1, miR-133, miR-206, miR-101, and let-7b, the biochemical roles of which have been demonstrated through experimental validation. [score:1]
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[+] score: 28
Overexpression of miR-133 could inhibit myoblast differentiation, but promotes myoblast proliferation by targeting SRF (serum response factor) [39]. [score:7]
Of the top 20 abundantly expressed miRNAs identified, some, such as miR-133, miR-10b, miR-26a, miR-30e and gga-miR-30a were also abundantly expressed in chicken somites [41]. [score:5]
Previous studies showed that miR-133a was specifically expressed in muscle and regulates the process of skeletal muscle proliferation [38]. [score:4]
miRNAs have an important role in muscle tissues during embryonic development and miR-133, miR-1 and miR-206 are crucial regulatory factors during myogenesis [19, 38, 42, 43]. [score:3]
In the present study, gga-miR-133 was expressed most highly in our samples, which indicated that it might also play a key role in chicken postnatal stages. [score:3]
miRNAs Normalized Reads Total Reads WRRh WRRl XHh XHl gga-miR-133a 3,558,683 3,069,071 1,997,286 2,607,787 11,232,827 gga-miR-133c 3,350,936 2,885,440 1,878,925 2,449,209 10,564,510 gga-miR-133b 3,326,848 2,864,578 1,864,721 2,431,274 10,487,421 gga-let-7a 1,699,621 1,513,865 857,210 1,133,532 5,204,228 gga-miR-22-3p 1,333,233 1,145,421 712,464 988,186 4,179,304 gga-miR-30a-5p 1,213,468 1,148,128 790,893 930,507 4,082,996 gga-miR-26a 1,212,635 1,054,689 691,456 1,006,522 3,965,302 gga-miR-30d 851,887 813,262 583,932 667,002 2,916,083 gga-miR-181a-6p 918,452 836,452 485,661 650,836 2,891,401 gga-miR-10a-5p 943,686 782,180 420,809 663,401 2,810,076 gga-miR-10b 911,725 757,564 398,852 633,567 2,701,708 gga-miR-30e 799,679 730,832 501,718 596,218 2,628,447 gga-let-7j 848,972 756,205 428,182 566,165 2,599,524 gga-let-7f 398,292 363,598 206,995 274,333 1,243,218 gga-miR-148a 288,585 300,432 144,015 180,973 914,005 gga-miR-146c-5p 224,147 207,782 171,443 132,712 736,084 gga-let-7k 211,853 206,518 118,297 155,412 692,080 gga-let-7c 242,661 189,820 111,118 139,257 682,856 gga-miR-199-3p 168,417 152,158 75,346 121,460 517,381 gga-miR-126-5p 139,914 109,805 89,607 86,681 426,007 Differentially expressed miRNAs were identified by DEGseq analysis (fold change > 1.5 or < 0.66; p-value < 0.05; q-value < 0.01), as a result, 200, 279, 257 and 297 miRNAs were detected in four comparisons of WRRh vs. [score:3]
The top 20 abundant known miRNAs in our libraries are listed in Table 2. The most abundant miRNAs is the gga-miR-133 family, which includes gga-miR-133a, gga-miR-133b and gga-miR-133c. [score:1]
Chen J. F. Man del E. M. Thomson J. M. Wu Q. Callis T. E. Hammond S. M. Conlon F. L. Wang D. Z. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation Nat. [score:1]
The three miRNAs of the gga-miR-133 family (gga-miR-133a, gga-miR-133b and gga-miR-133c) were the most abundant miRNAs in our breast muscle libraries. [score:1]
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[+] score: 14
16, 17, 18 miR-135 and miR-133 can bind to the 3'-UTR of MEF2C and MAML1, respectively, repress the expression of MEF2C and MAML1, thus inhibiting myoblast differentiation. [score:5]
[32] This skin-specific miRNA can also be expressed in early skeletal muscle cells, a finding that was similar to the three muscle-specific miRNAs miR-1, miR-133a and miR-206 that are expressed in brown pre- and mature adipocytes. [score:5]
[38] The most notable myomiRs, miR-206, miR-1 and miR-133a, are all significantly upregulated during muscle differentiation. [score:4]
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[+] score: 14
The expression level of myomiR miR-133 was lower than miR-206 in the skeletal muscle library, an outcome that could reflect differences in the roles of these miRNAs in terms of myogenesis regulation. [score:4]
miR-1 and miR-133 have been reported to regulate different aspects of skeletal muscle development in vitro and in vivo [19]. [score:3]
Consistent with this interpretation, miR-206 has been shown to promote skeletal muscle differentiation, whereas miR-133 regulates myogenesis by increasing muscle cell proliferation [19]. [score:2]
In particular, the critical roles of three muscle-specific miRNAs, miR-1, miR-133 and miR-206, in the regulation of myogenesis have been well documented [17, 18]. [score:2]
Compared with the three myomiRs, forms of the myomiR miR-133 were expressed at low levels in the skeletal muscle libraries: there were 126 reads for gga-miR-133a in the layers library and 67 in the broilers library; 7 reads for gga-miR-133b in the layers library and 12 in the broilers library; one gga-miR-133c read in the layers library and no read in the broilers library (Additional file 1). [score:2]
In C [2]C [12 ]myoblasts, miR-133a promotes proliferation, in part, by repressing serum response factor (SRF) [19]. [score:1]
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[+] score: 14
Among the known miRNAs, miR-10b-5p, gga-miR-148a-3p, gga-miR-22-3p and gga-miR-133a-3p were relatively high expressed in all three stages of chicken skeletal muscle development. [score:4]
Four myo-miRs (miR-1, miR-133a, miR-133b, and miR-206) accounted for nearly 25% of miRNA expression in skeletal muscle in both humans and mice [12]. [score:3]
Four myo-miRs, miR-1, miR-133a, miR-133b, and miR-206, together account for nearly 25% of miRNA expression in skeletal muscles in both humans and mice [12]. [score:3]
The 20 most abundant miRNAs in the three groups were ordered by the average proportion of each miRNA and included miR-148a-3p, miR-22-3p, miR-10b-5p, miR-181a-5p, miR-133a-3p, miR-126-5p, let-7f-5p, miR-10a-5p, miR-30c-5p, miR-146c-5p (Supplementary Table 1). [score:1]
Figure 2 The muscle specific miRNAs (myo-miR), miR-133a/b, miR-206, miR-486, miR-26a, miR-27b, miR-378, miR-148a and miR-181 were highly enriched in skeletal muscle and play key roles in skeletal muscle metabolism [11]. [score:1]
Figure 2The muscle specific miRNAs (myo-miR), miR-133a/b, miR-206, miR-486, miR-26a, miR-27b, miR-378, miR-148a and miR-181 were highly enriched in skeletal muscle and play key roles in skeletal muscle metabolism [11]. [score:1]
In this group, miR-10b-5p, miR-148a-3p and miR-133a-3p were the most abundant accounting for 79,359, 171,817 and 404,782 of total normalized miRNA reads from the E11, E16 and P1 libraries, respectively. [score:1]
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[+] score: 13
miR-133a has sharply increased expression during muscle differentiation and functions not only in the inhibition of muscle differentiation but also in the promotion of myoblast proliferation [42, 43]. [score:5]
However, the roles and expression pattern of miR-140-3p are similar to those of miR-133a, which is an important muscle-specific miRNA during muscle development [42, 43, 44]. [score:4]
Therefore, miR-140-3p may be a positive regulator during muscle development similar to miR-133a. [score:3]
Chen J. F. Man del E. M. Thomson J. M. Wu Q. Callis T. E. Hammond S. M. Conlon F. L. Wang D. Z. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation Nat. [score:1]
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[+] score: 10
Several well-known myogenic miRNAs, such as miR-1, miR-206, and miR-133, were reported to regulate muscle development by inhibiting target gene expression (Anderson et al., 2006; Chen et al., 2006). [score:9]
The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. [score:1]
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[+] score: 8
In this study, some of the DEMs relevant to the 11 intersection genes may be strong candidates for regulating AbF because miR-133c-3p, miR-133a-3p, miR-200a-3p, and miR-146b-5p were shown by independent qPCRs to be differentially expressed in birds with very high and very low AbF contents. [score:4]
Eleven of these (miR-204, miR-19a-3p, miR-19b-3p, miR-30d, miR-26a, miR-122-5p, miR-103-3p, miR-27b-3p, miR-92-3p, miR-142-3p, and miR-17-5p) have been implicated, directly or indirectly, in fat deposition; 9 showed a high fold-change (miR-3535, miR-144-3p, miR-30e-5p, miR-301b-3p, miR-215-5p, miR-200a-3p, miR-133a-3p, miR-133c-3p, and miR-146b-5p). [score:3]
Potentially novel miRNAs (gga-miR-3535, miR-30e-5p, miR-301b-3p, miR-215-5p, miR-200a-3p, miR-133a-3p, miR-133c-3p, and miR-146b-5p) and genes (LAMA2, RAP1B, PECR, AKT1, ITGALL and CHAD) related to abdominal adipose tissue were also identified. [score:1]
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[+] score: 7
Approximately 15.34% of the DEGs are targeted by at least two DEMs, and the LASP1 gene is regulated by seven DEMs (miR-24, miR-133a, miR-133b, let-7b, miR-20a, miR-20b and miR-130b). [score:4]
miR-206 and miR-133 are two well-known muscle-specific miRNAs that function in the regulation of muscle cell proliferation and differentiation [30, 60]. [score:2]
Chen J. F. Man del E. M. Thomson J. M. Wu Q. Callis T. E. Hammond S. M. Conlon F. L. Wang D. Z. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation Nat. [score:1]
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[+] score: 7
However, overlap between our data and zebra-fish cardiac enriched transcripts was limited to the miR499 and the miR133 family [26], while the Zebra fish cardiac enriched miR221 and miR130b miRNA transcripts showed significantly lower expression in our chicken heart data compared to embryo expression levels. [score:4]
Our data confirms previously recognized cardiac enriched miRNA expression transcripts like miR499 and the miR133 family. [score:3]
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[+] score: 6
Most of the changed microRNAs are involved in development (especially in the embryonic development) and some examples of them are miRNA-222, miRNA-383, miRNA-126, miRNA-133, miRNA-30, miRNA-10a, miRNA-196 and miRNA-18b. [score:3]
For examples, miRNA-222 is known as the regulator of kit ligand signaling during the recruitment and maintenance of precursor hematopoietic cells and it is involved in the regulation of cholesterol synthesis in embryonic liver [27]; and miR-133 has a number of effects on muscle cells including preventing skeletal differentiation, enhancing myoblast proliferation by repressing serum response factor (SRF) [54]. [score:3]
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[+] score: 6
Sweetman D. Goljanek K. Rathjen T. Oustanina S. Braun T. Dalmay T. Munsterberg A. Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133 Dev. [score:3]
Many studies also demonstrated that miR-1/206 and miR-133a/133b families were necessary for proper skeletal and cardiac muscle development, and had a profound function on multiple myopathies, such as hypertrophy, dystrophy, and conduction defects [13]. [score:2]
Among these muscle-specific miRNAs, the most wi dely studied miRNAs were members of the miR-1/206 and miR-133a/133b families which highly enriched in both human and mouse heart and skeletal muscle [12]. [score:1]
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[+] score: 5
An in silico search for putative binding sites of differentially abundant miRNAs was performed using TargetScan 6.0 [26]; note that non-conserved miRNAs (ENSGALT00000042483-3p, ENSGALT00000043002-3p, ENSGALT00000043002-5p, gga-miR-1736-3p) and those with borderline differential abundance (adjusted P-values of 0.0498; ccr-miR-133a-5p, mmu-miR-144-5p, gga-miR-20a, aca-miR-499-3p) were not included in the functional analysis. [score:3]
b Difference with ccr-miR-133a: extra UG in 3′. [score:1]
This set includes five mature miRNAs (hsa-let-7a-3p, ccr-miR-133a-5p, mmu-miR-144-5p, aca-miR-21-3p and hsa-miR-30c-2-3p), which are present in miRBase as Gallus gallus mature miRNAs with a different 3′ editing (Table 2). [score:1]
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[+] score: 5
As illustrated in Fig 3, 7 miRNAs including miR-29c, miR-217, miR-375, miR-215, miR-19b, miR-133a and let-7a had relatively low and stable expression levels (P < 0.05) in early period, and increased significantly (P < 0.01) from 12 to 13 weeks when the gonads entered into rapid development. [score:4]
According to previous reports and our sequencing results, 9 miRNAs, including miR-29c-3p, miR-375, miR-215-5p, miR-9-5p, miR-19b-3p, miR-133a-3p, let-7a, miR-217-5p and miR-155 were determined as candidates. [score:1]
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[+] score: 4
The two remaining miRNAs, miR-133 and miR-279, showed low levels of expression during the whole 4 [th ]molt stage (Additional file 7). [score:3]
However, a higher number of miRNAs were initially present in day 9 embryos (9 d Em) at the body pigmentation stage, including miR-281-5p, miR-281-3p, miR-263, miR-970, miR-133, miR-283, and miR-317. [score:1]
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[+] score: 4
Additionally, an increasing number of reports indicate that microRNAs (miRNAs), such as let-7b, miR-1, miR-133 and miR-206 [13, 14], function in animal growth by regulating their target genes. [score:4]
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This lncRNA acts as a competing endogenous RNA and “sponges” miR-133 and miR-135 to regulate the expression of MAML1 and MEF2C, which are transcription factors that activate late-differentiation muscle genes (Cesana et al., 2011). [score:4]
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[+] score: 4
Other miRNAs from this paper: gga-mir-30a, gga-mir-133a-2, gga-mir-193a
In preliminary studies, we found that miR-30a [10], miR-193a-3p and miR-133a-3p were down-regulated in NSCLC tissues [11, 12], and all of them have an effect on survival time of patients. [score:4]
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[+] score: 3
The miRNA miR-133 promotes myoblast proliferation through the SRF gene, inhibiting myoblast differentiation [38]. [score:3]
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[+] score: 3
A muscle-specific mouse lncRNA (linc-MD1) is a competitive endogenous RNA for miR-133 and miR-135 targets. [score:3]
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[+] score: 2
Differences in epigenetics between breeds[55] Insulin-like growth factor-1 receptor is regulated by microRNA-133 during skeletal myogenesis. [score:2]
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[+] score: 2
Several miRNAs, including the miR-183 family, miR-96, miR-15, miR-99, miR-100, miR-125, and miR-133, all might contribute to hair cell development and maintenance [23– 26]. [score:2]
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[+] score: 2
Besides, some of the muscle-specific miRNAs, such as miR-1, miR-133 and miR-206, can also be regulated by MYOD during myoblast differentiation. [score:2]
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[+] score: 2
Additional data indicate that FGF and BMP signaling pathway interactions are regulated by negative feedback loops involving microRNAs, particularly miR-130 and miR-133 [48, 49]. [score:2]
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[+] score: 1
Other miRNAs from this paper: gga-let-7i, gga-let-7d, gga-let-7f, gga-mir-133a-2
Li H, Yang J, Wei X, Song C, Dong D, Huang Y, Lan X, Plath M, Lei C, Ma Y, Qi X, Bai Y, Chen H. CircFUT10 reduces proliferation and facilitates differentiation of myoblasts by sponging miR-133a. [score:1]
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