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20 publications mentioning gga-mir-200b

Open access articles that are associated with the species Gallus gallus and mention the gene name mir-200b. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.

1
[+] score: 35
RECK, the putative target of gga-miR-200b, is down-regulated by MyoD to facilitate myotube formation, and up-regulated by MRF4 to promote other aspects of myogenesis [51]. [score:9]
Therefore, although little is known about the specific functions of several of these miRNAs (e. g. miR-31, miR-101, miR-200b, miR-10b, miR-460, miR-15b, miR-16 and miR203) during muscle development, the close relationship between their targets and myogenesis regulation demonstrates a potential role during muscle development. [score:6]
Seven (miR-101, miR-10a, miR-10b, miR-1677, let-7f, miR-31, and miR-205b) were expressed at higher levels in layers, and ten (miR-203, miR-200b, miR-16c, miR-15b, miR-15c, miR-460, miR-429, let-7c, miR-2188, and gga-miR-N2) were expressed at higher levels in broilers. [score:5]
For example, miR-200b has eight predicted targets, among which are three genes RECK, SLC38A2 and Nr5a2, which encode proteins that are reported to be involved in muscle development [51- 53]. [score:4]
However, the majority including one novel miRNAs (gga-miR-N2) and eight known miRNAs (miR-101, miR-15b, miR-15c, miR-1677, miR-200, miR-460, gga-mir-2188 and miR-429) have not been implicated in the regulation of muscle development. [score:3]
SLC38A2, encoding a sodium-coupled amino acid transporter, is the putative target of gga-miR-200b. [score:3]
Nr5a2 is the putative target of gga-miR-200b, gga-miR-128 and gga-miR-27b. [score:3]
Little is known about the functional roles of the remaining eight (miR-31, miR-101, miR-200b, miR-10b, miR-460, miR-15b, miR-16 and miR-203) during muscle development. [score:2]
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2
[+] score: 31
We observed the uncoupling of HMGCR mRNA (up-regulated) and protein (unchanged) in the liver of leptin -treated chicks, which coincided with significantly increased expression of gga-miR-200a gga-miR-200b and gga-miR-429 that were predicted to target the chicken HMGCR gene. [score:8]
Moreover, out of 12 miRNAs targeting SREBP-1c and/or HMGCR, five were significantly up-regulated in liver of leptin -treated chicks, including gga-miR-200b and gga-miR-429, which target both SREBP-1c and HMGCR. [score:8]
Among the five miRNAs predicted to target SREBP-1c, gga-miR-99a, gga-miR-100, gga-miR-200b and gga-miR-429 were found to be significantly (P < 0.05) up-regulated in the liver of leptin -treated chickens. [score:6]
Among the nine miRNAs predicted to target HMGCR, the expression of gga-miR-200a, gga-miR-200b and gga-miR-429 was significantly increased (P < 0.05). [score:5]
It is worth noting that gga-miR-200b and gga-miR-429 were predicted to target both SREBP-1c and HMGCR (Table 5). [score:3]
It is noteworthy that gga-miR-99a and gga-miR-100 belong to the miRNA gene family of miR-99, while the remaining three miRNAs, gga-miR-200a, gga-miR-200b and gga-miR-429, belong to the miRNA gene family of miR-8, located in the same miRNA cluster. [score:1]
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3
[+] score: 19
Another upregulated miR-200b target in the posthatch liver is LPIN1 (Fig. 2). [score:6]
Many SREBF1 regulated genes are also regulated by miRNAs, including let-7c, miR-200b, miR-107, and miR-18a Fig. 2Differential hepatic expression of a lipid metabolism network involving FADS2 and SCD and associated miRNA between E18 and D3 chickens. [score:5]
Interestingly, both ACACA and SCD mRNAs are predicted to be regulated by miR-200b, a downregulated miRNA in the posthatch liver (Fig. 2). [score:5]
Many SREBF1-regulated genes are also regulated by miRNAs, including let-7c, miR-200b, miR-107, and miR-18a. [score:3]
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4
[+] score: 13
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-25, mmu-let-7g, mmu-let-7i, mmu-mir-124-3, mmu-mir-9-2, mmu-mir-134, mmu-mir-137, mmu-mir-138-2, mmu-mir-145a, mmu-mir-24-1, hsa-mir-192, mmu-mir-194-1, mmu-mir-200b, hsa-mir-7-1, hsa-mir-7-2, hsa-mir-7-3, hsa-mir-215, hsa-mir-221, hsa-mir-200b, mmu-mir-296, mmu-let-7d, mmu-mir-106b, hsa-let-7g, hsa-let-7i, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-137, hsa-mir-138-2, hsa-mir-145, hsa-mir-9-1, hsa-mir-9-2, hsa-mir-9-3, hsa-mir-134, hsa-mir-138-1, hsa-mir-194-1, mmu-mir-192, mmu-mir-200a, mmu-let-7a-1, mmu-let-7a-2, mmu-let-7b, mmu-let-7c-1, mmu-let-7c-2, mmu-let-7e, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-24-2, mmu-mir-346, hsa-mir-200c, mmu-mir-17, mmu-mir-25, mmu-mir-200c, mmu-mir-221, mmu-mir-124-1, mmu-mir-124-2, mmu-mir-9-1, mmu-mir-9-3, mmu-mir-138-1, mmu-mir-7a-1, mmu-mir-7a-2, mmu-mir-7b, hsa-mir-194-2, mmu-mir-194-2, hsa-mir-106b, hsa-mir-200a, hsa-mir-296, hsa-mir-369, hsa-mir-346, mmu-mir-215, gga-let-7i, gga-let-7a-3, gga-let-7b, gga-let-7c, gga-mir-221, gga-mir-17, gga-mir-138-1, gga-mir-124a, gga-mir-194, gga-mir-215, gga-mir-137, gga-mir-7-2, gga-mir-138-2, gga-let-7g, gga-let-7d, gga-let-7f, gga-let-7a-1, gga-mir-200a, gga-mir-124b, gga-let-7a-2, gga-let-7j, gga-let-7k, gga-mir-7-3, gga-mir-7-1, gga-mir-24, gga-mir-7b, gga-mir-9-2, dre-mir-7b, dre-mir-7a-1, dre-mir-7a-2, dre-mir-192, dre-mir-221, dre-mir-430a-1, dre-mir-430b-1, dre-mir-430c-1, dre-let-7a-1, dre-let-7a-2, dre-let-7a-3, dre-let-7a-4, dre-let-7a-5, dre-let-7a-6, dre-let-7b, dre-let-7c-1, dre-let-7c-2, dre-let-7d-1, dre-let-7d-2, dre-let-7e, dre-let-7f, dre-let-7g-1, dre-let-7g-2, dre-let-7h, dre-let-7i, dre-mir-7a-3, dre-mir-9-1, dre-mir-9-2, dre-mir-9-4, dre-mir-9-3, dre-mir-9-5, dre-mir-9-6, dre-mir-9-7, dre-mir-17a-1, dre-mir-17a-2, dre-mir-24-4, dre-mir-24-2, dre-mir-24-3, dre-mir-24-1, dre-mir-25, dre-mir-92b, dre-mir-124-1, dre-mir-124-2, dre-mir-124-3, dre-mir-124-4, dre-mir-124-5, dre-mir-124-6, dre-mir-137-1, dre-mir-137-2, dre-mir-138-1, dre-mir-145, dre-mir-194a, dre-mir-194b, dre-mir-200a, dre-mir-200b, dre-mir-200c, dre-mir-430c-2, dre-mir-430c-3, dre-mir-430c-4, dre-mir-430c-5, dre-mir-430c-6, dre-mir-430c-7, dre-mir-430c-8, dre-mir-430c-9, dre-mir-430c-10, dre-mir-430c-11, dre-mir-430c-12, dre-mir-430c-13, dre-mir-430c-14, dre-mir-430c-15, dre-mir-430c-16, dre-mir-430c-17, dre-mir-430c-18, dre-mir-430a-2, dre-mir-430a-3, dre-mir-430a-4, dre-mir-430a-5, dre-mir-430a-6, dre-mir-430a-7, dre-mir-430a-8, dre-mir-430a-9, dre-mir-430a-10, dre-mir-430a-11, dre-mir-430a-12, dre-mir-430a-13, dre-mir-430a-14, dre-mir-430a-15, dre-mir-430a-16, dre-mir-430a-17, dre-mir-430a-18, dre-mir-430i-1, dre-mir-430i-2, dre-mir-430i-3, dre-mir-430b-2, dre-mir-430b-3, dre-mir-430b-4, dre-mir-430b-6, dre-mir-430b-7, dre-mir-430b-8, dre-mir-430b-9, dre-mir-430b-10, dre-mir-430b-11, dre-mir-430b-12, dre-mir-430b-13, dre-mir-430b-14, dre-mir-430b-15, dre-mir-430b-16, dre-mir-430b-17, dre-mir-430b-18, dre-mir-430b-5, dre-mir-430b-19, dre-mir-430b-20, mmu-mir-470, hsa-mir-485, hsa-mir-496, dre-let-7j, mmu-mir-485, mmu-mir-543, mmu-mir-369, hsa-mir-92b, gga-mir-9-1, hsa-mir-671, mmu-mir-671, mmu-mir-496a, mmu-mir-92b, hsa-mir-543, gga-mir-124a-2, mmu-mir-145b, mmu-let-7j, mmu-mir-496b, mmu-let-7k, gga-mir-124c, gga-mir-9-3, gga-mir-145, dre-mir-138-2, dre-mir-24b, gga-mir-9-4, mmu-mir-9b-2, mmu-mir-124b, mmu-mir-9b-1, mmu-mir-9b-3, gga-mir-9b-1, gga-let-7l-1, gga-let-7l-2, gga-mir-9b-2
miR-200 negatively regulates the expression of Sox2 and E2F3, a pluripotency factor and a cell cycle regulator, respectively (Johnson and Walker, 1999; Peng et al., 2012). [score:5]
The lack of Sox2 and E2F3 regulation by miR-200 results in reduced cell cycle exit and neuronal differentiation of ventral midbrain/hindbrain (vMH) NPs while, overexpression of miR-200 in primary vMH NPs results in the opposite effect (Peng et al., 2012) indicating that these interactions control the proliferative state of vMH NPs (Figure 2). [score:4]
Interestingly, both TFs Sox2 and E2F3 activate miR-200 transcription which establish a negative feedback loop between miR-200 and its target genes that guaranty NPs cell cycle exit and differentiation in the midbrain/hindbrain region (MHR) (Peng et al., 2012). [score:3]
A unilateral negative feedback loop between miR-200 microRNAs and Sox2/E2F3 controls neural progenitor cell-cycle exit and differentiation. [score:1]
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5
[+] score: 13
According to the microarray data, quercetin treatment led to the up-regulation of let-7c, miR-200a-3p and miR-200b-3p and the down-regulation of miR-103a-3p, miR-125b-5p and miR-1202 (Figure 1B). [score:7]
The mean fold change of CRL-4023 was set to 1. Table 1Summary of in-silico analysis ID Confidence Gene Pathway let-7c High (predicted) NUMBL Notch Signaling miR-103a-3p Moderate (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling miR-1202 High (predicted) NUMBL Notch Signaling miR-125b-5p High (predicted) NUMBL Notch Signaling miR-1268a Moderate (predicted) NUMBL Notch Signaling miR-200a-3p High (predicted) NUMBL Notch Signaling miR-6088 Moderate (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling miR-200b-3p High (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling miR-3665 Moderate (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling miR-4651 High (predicted) NUMBL Notch Signaling miR-96-5p High (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling To validate Numbl as a target gene for let-7c, firstly, the putative binding site of let-7c in the Numbl 3′-UTR was identified using the TargetScan database and the resulting sequence homology at base pairs 626–632 are shown (Figure 2A, Supplementary Data 1). [score:5]
The mean fold change of CRL-4023 was set to 1. Table 1Summary of in-silico analysis ID Confidence Gene Pathway let-7c High (predicted) NUMBL Notch Signaling miR-103a-3p Moderate (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling miR-1202 High (predicted) NUMBL Notch Signaling miR-125b-5p High (predicted) NUMBL Notch Signaling miR-1268a Moderate (predicted) NUMBL Notch Signaling miR-200a-3p High (predicted) NUMBL Notch Signaling miR-6088 Moderate (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling miR-200b-3p High (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling miR-3665 Moderate (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling miR-4651 High (predicted) NUMBL Notch Signaling miR-96-5p High (predicted) NUMB Clathrin -mediated Endocytosis Signaling, Notch Signaling A. AsPC-1 cells were left untreated (CO) or were treated with quercetin (Q, 50 μM). [score:1]
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6
[+] score: 12
The most significantly differentially expressed were gga-miR-206 (3.5-fold), gga-miR-31 (2.5-fold), gga-miR-3535 (2.5-fold), gga-miR-17–3p (2.3-fold), gga-miR-429 (2.3-fold) and gga-miR-200b (2.2-fold), and in comparison, gga-miR-454 (-2.9-fold) and gga-miR-1b (-2.7-fold) were those mostly down-regulated in the fat line (Fig. 4). [score:6]
Last but not least, expression levels of 10 miRNAs can be perturbed in animals when fed with high-fat diet (miR-142–5p and miR-101) [74– 78], or with obesity or obesity-related diseases (miR-10a, miR-218, miR-429, miR-200a, miR-200b, miR-451, miR-142–3p, and miR-454) [77, 79– 85], which indicates that they could be potentially related to adipogenesis. [score:5]
S2 Fig miR-200b and miR-429 share the biggest number of common genes. [score:1]
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7
[+] score: 11
In human cell lines, mir-200b was shown to inhibit the TLR4 pathway (Wendlandt et al., 2012), mir-221 increased the expression of NF-κβ and STAT3 (Liu et al., 2014), and mir-193b overexpression resulted in increased autophagy (Nyhan et al., 2016). [score:7]
Avian influenza impacted the expression levels of several miRNAs in the chicken trachea and lung including the following miRNAs significant in the current study: let-7a-1, let-7f, let-7j, mir-1b, mir-30d, mir-34c, mir-101-2, mir-144, mir-200b, and mir-451 (Wang et al., 2009). [score:3]
The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-kappaB activation. [score:1]
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8
[+] score: 10
Other miRNAs from this paper: hsa-mir-200b, hsa-mir-200c, hsa-mir-200a, gga-mir-200a
The microRNA-200 family is involved in cdh1 regulation, through direct targeting of transcriptional repressors, such as ZEB1 and ZEB2 [35]. [score:5]
The involvement of the microRNA-200 family in cdh1 regulation, through direct targeting of transcriptional repressors, such as ZEB1 and ZEB2, has been recently highlighted [35]. [score:5]
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9
[+] score: 8
Other miRNAs from this paper: gga-mir-153, gga-mir-34c, gga-mir-1643, gga-mir-1680, gga-mir-1786
Furthermore, miR-200b and miR-1786 decreased the intensity and percentage of GFP-ZEB1 -expressing-cells by 63% and 66%, respectively (Figure 15). [score:3]
0096175.g015 Figure 15 In vitro target assay for miR-200b and miR-1786 on the ZEB1 transcript. [score:2]
In vitro target assay for miR-200b and miR-1786 on the ZEB1 transcript. [score:2]
It revealed several putative binding sites for miRNAs including miR-153 and miR-1643 for SNCA, miR-1680* for TTR and miR-200b and miR-1786 for ZEB1 (Figures 13, 14 and 15). [score:1]
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10
[+] score: 8
During comprehensive analyses of the impact of two Lactobacillus species, Lactobacillus paracasei CNCM I-3689 and Lactobacillus casei BL23, on Listeria monocytogenes infection in a gnotobiotic mouse mo del, Archambaud et al. (6) found that three miRNAs (miR-192, miR-200b, and miR-215) were repressed during L. monocytogenes infection and treatment with each Lactobacillus increased miR-192 expression, whereas only L. casei increased miR-200b and miR-215 expression in ilea. [score:5]
L. monocytogenes infection reduced expression of miR-143, miR-148a, miR-200b, miR-200c, and miR-378 in intestine upon L. monocytogenes infection (7). [score:3]
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11
[+] score: 7
Other miRNAs from this paper: gga-mir-19a, gga-mir-18a, gga-mir-23b, gga-mir-383
Among the predicted miRNA-target relationships, correlations between miR-18a, miR-19a and the target THBS1 are reported to be involved in angiosarcomas 19, while the correlation between miR-200b and target FN1 is associated with ovarian cancer 20. [score:7]
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12
[+] score: 6
Additionally, miR-200a, miR-200b, miR-203, miR-27a, and miR-27b, all of which interact with Wnt signaling components [63], [64], [65], are expressed at 1.5- to 58.9-fold higher levels in duck verses the other species (Table S7). [score:3]
Among this group, miR-200a and miR-200b are remarkable in both showing greater than 50-fold changes in expression between duck and chicken at HH25. [score:3]
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13
[+] score: 5
N1 gga-miR-199b 1.92 2.15E-04 Up gga-miR-6651-5p 1.95 9.19E-03 Up gga-miR-31-5p −2.28 3.36E-16 Down gga-miR-200b-5p −1.78 1.31E-08 Down gga-miR-365-2-5p −1.99 4.74E-06 Down gga-miR-211 −2.21 9.36E-06 Down gga-miR-204 −2.21 9.36E-06 Down gga-miR-200a-5p −1.21 1.40E-05 Down gga-miR-146a-5p −1.07 7.10E-04 Down gga-miR-1674 −2.79 1.20E-03 Down gga-miR-1552-5p −1.02 4.91E-03 Down Differentially expressed miRNA of each comparison were selected with a setting of q value < 0.01 and fold change > 2 The analysis of differentially expressed genes revealed a significant difference in skin tissues between early-feathering and late-feathering birds. [score:5]
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14
[+] score: 3
The reproducibility of these results was tested by Taqman RT-PCR, selecting 18 miRNAs (hsa-let-7a, hsa-miR-141, hsa-miR-143, hsa-miR-145, hsa-miR-17, hsa-miR-182, hsa-miR-191, hsa-miR-199a-5p, hsa-miR-200a, hsa-miR-200b, hsa-miR-222, hsa-miR-29b, hsa-miR-34a, hsa-miR-424, hsa-miR-15a, hsa-miR-199a-3p, hsa-miR-26b, hsa-miR-361-3p) previously showing at least a three-fold modulation in expression in a wide panel of PDAC cell lines 49. [score:3]
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15
[+] score: 3
Expression patterns of 15 miRNAs identified using RT-PCR agreed with those identified using deep sequencing, miR-101, miR-10a, miR-10b, miR-1677, let-7f, and miR-31 were higher in layers, while miR-200b, let-7c, miR-16c, miR15b, miR-15c, miR460, miR-429, miR-2188, and the novel miR-N2 were higher in broilers. [score:3]
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16
[+] score: 2
Recently, the miR-200 family was implicated in ovarian cancer initiation and progression via stage-specific regulation [55]. [score:2]
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17
[+] score: 2
Furthermore, in the E11_VS_E16 contrast group, 8 miRNAs (miR-203a, miR-6561-5p, miR-460a-5p, miR-205a, miR-3536, miR-103-3p miR-205b, and miR-200b-3p) were highly regulated. [score:2]
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18
[+] score: 1
Other miRNAs from this paper: hsa-let-7d, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-21, hsa-mir-22, hsa-mir-30a, hsa-mir-32, hsa-mir-33a, hsa-mir-148a, hsa-mir-30c-2, hsa-mir-30d, hsa-mir-147a, hsa-mir-34a, hsa-mir-187, hsa-mir-204, hsa-mir-205, hsa-mir-200b, hsa-mir-23b, hsa-mir-30b, hsa-mir-125b-1, hsa-mir-138-2, hsa-mir-142, hsa-mir-144, hsa-mir-125b-2, hsa-mir-138-1, hsa-mir-146a, hsa-mir-190a, hsa-mir-200c, hsa-mir-155, hsa-mir-30c-1, hsa-mir-200a, hsa-mir-30e, hsa-mir-365b, hsa-mir-328, gga-mir-33-1, gga-mir-125b-2, gga-mir-155, gga-mir-17, gga-mir-148a, gga-mir-138-1, gga-mir-187, gga-mir-32, gga-mir-30d, gga-mir-30b, gga-mir-30a, gga-mir-30c-2, gga-mir-190a, gga-mir-204-2, gga-mir-138-2, gga-let-7d, gga-let-7f, gga-mir-146a, gga-mir-205b, gga-mir-200a, gga-mir-34a, gga-mir-30e, gga-mir-30c-1, gga-mir-205a, gga-mir-204-1, gga-mir-23b, gga-mir-142, hsa-mir-449a, hsa-mir-489, hsa-mir-146b, hsa-mir-548a-1, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-33b, hsa-mir-449b, gga-mir-146b, gga-mir-147, gga-mir-489, gga-mir-449a, hsa-mir-449c, gga-mir-21, gga-mir-144, gga-mir-460a, hsa-mir-147b, hsa-mir-190b, gga-mir-22, gga-mir-460b, gga-mir-1662, gga-mir-1684a, gga-mir-449c, gga-mir-146c, gga-mir-449b, gga-mir-2954, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, gga-mir-365b, gga-mir-33-2, gga-mir-125b-1, gga-mir-190b, gga-mir-449d, gga-mir-205c
Nonetheless, miR-142-3p, miR-449-5p, miR-148a-5p, miR-365b-5p, miR-200-3p, miR-34a-5p and miR-1443-3p found in our results have few reported associations to PAH. [score:1]
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19
[+] score: 1
miR-200b and miR-429 are linked to function in mouse ovulation and fertility [40]. [score:1]
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20
[+] score: 1
The role of microRNAs miR-200b and miR-200c in TLR4 signaling and NF-κB activation. [score:1]
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